Chiral ketones have been shown to be effective organocatalysts for asymmetric epoxidation of olefins with broad substrate scope. High enantioselectivity has been obtained for a wide variety of trans and trisubstituted olefins, as well as a number of cis olefins, with encouragingly high ee's for some terminal olefins. The stereochemical outcome of the reaction can be rationalized by a spiro transition state model.
Accounts of chemical research. 2004 Aug;37(8):488-96. doi: 10.1021/ar030063x Q117.72025
Organocatalytic asymmetric epoxidation of olefins by chiral ketones
手性的酮催化的烯烃不对称环氧化反应 翻译改进
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DOI: 10.1021/ar030063x PMID: 15311947
摘要 Ai翻译
Keywords：chiral ketones
关键词：有机催化不对称环氧化; 手性酮
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