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Breast cancer (Tokyo, Japan). 2014 Nov;21(6):715-23. doi: 10.1007/s12282-013-0447-5 Q14.02024

Collapsin response mediator protein 2 is involved in regulating breast cancer progression

collapsin反应调解蛋白2参与调节乳腺癌进展 翻译改进

Kazuhiro Shimada  1, Takashi Ishikawa, Fumio Nakamura, Daisuke Shimizu, Takashi Chishima, Yasushi Ichikawa, Takeshi Sasaki, Itaru Endo, Yoji Nagashima, Yoshio Goshima

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作者单位

  • 1 Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan, kazu90052003@yahoo.co.jp.
  • DOI: 10.1007/s12282-013-0447-5 PMID: 23381229

    摘要 Ai翻译

    Background: Altered expression of collapsin response mediator proteins (CRMPs) has been reported in several malignant tumors, including downregulation of CRMP1 in lung cancer and upregulation of CRMP2 in colorectal cancer. This study aimed to investigate the relationship between CRMP expression and clinicopathological characteristics in patients with breast cancer.

    Methods: Twenty-two breast cancer and four normal breast tissues were used to assess CRMP mRNA expression. The average expression level of each CRMP (CRMP1-5) mRNA was analyzed in a subset of breast cancer specimens and compared with that in normal breast tissue by real-time quantitative reverse-transcription polymerase chain reaction. Furthermore, 173 breast cancer specimens and matching normal breast controls were used for immunohistochemistry based on the tissue microarray technique. Levels of CRMP2 and phosphorylated CRMP2 protein were assessed, and possible correlations between the clinicopathological characteristics were evaluated.

    Results: The expression of CRMP2 mRNA was significantly decreased in breast cancer tissues, while that of the other CRMPs was similar between normal and breast cancer tissues. Immunohistochemistry revealed that CRMP2 protein expression was also decreased in breast cancer tissues (P < 0.001). Phosphorylated CRMP2 was observed in the nuclei of breast cancer cells but not in normal mammary cells (P < 0.001). Furthermore, nuclear phosphorylated CRMP2 expression was increased in proportion to the histological grade and triple-negative subtype.

    Conclusions: Reduced CRMP2 expression and elevated expression of nuclear phosphorylated CRMP2 may be associated with breast cancer progression.

    Keywords:breast cancer; progression

    Copyright © Breast cancer (Tokyo, Japan). 中文内容为AI机器翻译,仅供参考!

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    期刊名:Breast cancer

    缩写:BREAST CANCER-TOKYO

    ISSN:1340-6868

    e-ISSN:1880-4233

    IF/分区:4.0/Q1

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    Collapsin response mediator protein 2 is involved in regulating breast cancer progression