Ischemic heart disease (IHD) is the leading cause of death in the United States today. This year over 750,000 women will have a new or recurrent myocardial infarction. Currently, the mainstay of therapy for IHD is revascularization. Increasing evidence, however, suggests that revascularization alone is insufficient for the longer-term management of many patients with IHD. To address these issues, innovative therapies that extend beyond revascularization to protection of the myocyte and preservation of ventricular function are required. The emergence of gene therapy and proteomics offers the potential for innovative prophylactic and treatment strategies for IHD. The goal of our research is to develop therapeutic gene constructs for the treatment of myocardial ischemia that are clinically safe and effective. Toward this end, we describe the development of physiologic regulation of gene delivery and expression using bioreducible polymers and ischemia-inducible gene therapies for the potential treatment of ischemic heart disease in women.
Review Advanced drug delivery reviews. 2009 Aug 10;61(10):863-70. doi: 10.1016/j.addr.2009.04.013 Q117.62025
Women and heart disease--physiologic regulation of gene delivery and expression: bioreducible polymers and ischemia-inducible gene therapies for the treatment of ischemic heart disease
女性与心脏病：基因传递和表达的生理调节：治疗缺血性心脏疾病的生物可降解聚合物和心肌梗死感应型基因疗法 翻译改进
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DOI: 10.1016/j.addr.2009.04.013 PMID: 19422868
摘要 Ai翻译
Keywords：heart disease; gene delivery; bioreducible polymers
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期刊名：Advanced drug delivery reviews
缩写：ADV DRUG DELIVER REV
ISSN：0169-409X
e-ISSN：1872-8294
IF/分区：17.6/Q1