Comparative Risk of Intracranial Hemorrhage With Tenecteplase Versus Alteplase in Acute Ischemic Stroke [0.03%]
阿替普酶与尼莫地普酶用于急性缺血性卒中静脉溶栓的颅内出血风险比较研究
Katherine Hammaker,Stephanie Bills,Taylor H Cason et al.
Katherine Hammaker et al.
Background: In patients with acute ischemic stroke (AIS), tenecteplase and alteplase help preserve brain tissue. The 2019 American Heart Association/American Stroke Association guidelines designate alteplase as the first-line therapy for AI...
Extending Universal Licensing Recognition (ULR) Laws to Licensure Renewal: A Pharmacist Case Study [0.03%]
执业续期中的通用发牌互认制度(ULR):药剂师案例研究
Alex Adams,Edward J Timmons
Alex Adams
Universal Licensing Recognition (ULR) laws have emerged as a key policy tool to improve license mobility by allowing licensure obtained in one state to be more easily recognized in another. While these reforms have increased access to licen...
Direct Oral Anticoagulant Transition Strategies Using Anti-Xa Concentrations Upon Intensive Care Unit Admission [0.03%]
基于抗Xa浓度的直接口服抗凝剂在重症监护病房的转换策略
Mariah I Sigala,Corey V Dinunno,Chelsea N Lopez et al.
Mariah I Sigala et al.
Background: The increased utilization of oral factor Xa inhibitors (FXaI) has led to a growing interest in the clinical utility of FXaI-specific anti-Xa concentrations. Critically ill populations are at risk of bleeding secondary to FXaI ac...
David Hensler,Danielle Burghardt
David Hensler
Objective: Therapeutic plasma exchange (TPE) may enhance the elimination of drugs from human plasma. Removal of apixaban during TPE has not been extensively described previously. Case: This is a retrospective report of a 76-year-old man adm...
Impact of an Interruptive Alert on the Number of Women Receiving CDC-Recommended Therapy for Trichomoniasis [0.03%]
干扰性警报对接受CDC推荐治疗的妇女念珠菌病人数的影响
Nicole Sunshine,Rachel M Kenney,Nathan A Everson et al.
Nicole Sunshine et al.
Background: The 2021 Centers of Disease Control and Prevention (CDC) sexually transmitted infection treatment guidelines recommend a 7-day course of metronidazole or single-dose tinidazole for women with trichomoniasis due to improved patie...
Doxycycline for Legionella Pneumonia: Expanding Treatment Horizons Through a Case Series and Narrative Review [0.03%]
多西环素治疗军团病肺炎：通过病例系列和叙述性综述拓展治疗视野
M Gabriela Cabanilla,Aileen C Scheibner,Jorge R Mera
M Gabriela Cabanilla
Background: Legionella pneumonia is a significant cause of community-acquired pneumonia that often requires timely and effective treatment. While fluoroquinolones and macrolides are the recommended first-line therapies, doxycycline offers a...
A Retrospective Within-Subjects Analysis of Vancomycin Bayesian Modeling With Pre-steady-State vs Steady-State Concentrations [0.03%]
基于预稳态与稳态浓度万古霉素贝叶斯剂量个体化研究回顾性分析
Elizabeth W Covington,Jihyun L Chae,Sarah Grace Gunter
Elizabeth W Covington
Background: Bayesian modeling of vancomycin can estimate 24-hour area under the curve (AUC24) using pre-steady-state concentrations. Limited literature exists comparing Bayesian AUC24 calculations derived from steady-state versus pre-steady...
Proton Pump Inhibitor Use in Patients With Cirrhosis and Its Association With Spontaneous Bacterial Peritonitis [0.03%]
肝硬化患者使用质子泵抑制剂及其与自发性细菌性腹膜炎的关系
Morgan Thomas,Cameron Lanier,Kelly Covert
Morgan Thomas
Background: Cirrhosis is a major cause of morbidity and mortality in the United States, with spontaneous bacterial peritonitis (SBP) being a serious complication. Established SBP risk factors include gastrointestinal bleeding and low asciti...
Effect of Intravenous Electrolyte Supplementation on Refeeding Syndrome for Patients Initiated on Parenteral Nutrition [0.03%]
静脉电解质补充对启动肠外营养患者发生再喂养综合症的影响分析
Makayla F Hoke,Katelyn A Butler,Marcos J Ortiz-Uriarte et al.
Makayla F Hoke et al.
Background: Refeeding syndrome (RS) is a potentially life-threatening condition, marked by decreases in serum phosphorus, potassium, or magnesium, that commonly occurs in patients who receive parenteral nutrition (PN) after a period of inad...
Evaluating the Effectiveness of a Pharmacist-Driven Warfarin Consult Service Versus Physician Management in a Tertiary Community Hospital [0.03%]
三级社区医院药剂师驱动的华法林咨询项目与医师管理的有效性比较研究
Erik Wasowski,Anne Harris,Taylor Elias
Erik Wasowski
Background: The use of warfarin is complicated by a narrow therapeutic window, requiring close monitoring to prevent serious adverse events. Literature has shown that pharmacist-led warfarin management improves patient outcomes and decrease...