Pharmacological Inhibition of HDAC6 Transiently Reduces Voluntary Ethanol Consumption in Male Mice [0.03%]
组蛋白去乙酰化酶6的药理学抑制可短暂降低雄性小鼠的自愿摄入酒精量
Kiera Fleck,Jeffery L Dunning,Max Kreifeldt et al.
Kiera Fleck et al.
Background: Histone deacetylase 6 (HDAC6) inhibition can alleviate depression- and anxiety-like behaviors. Accordingly, HDAC6 may be a promising target to mitigate negative reinforcement in alcohol use disorder (AUD). We ...
Pharmacological Inhibition of HDAC6 Transiently Reduces Voluntary Ethanol Consumption in Male Mice [0.03%]
组蛋白去乙酰化酶6的药理学抑制可使小鼠短暂减少自愿摄入乙醇
Kiera Fleck,Jeffery L Dunning,Max Kreifeldt et al.
Kiera Fleck et al.
Background: Histone deacetylase 6 (HDAC6) inhibition can alleviate depression- and anxiety-like behaviors. Accordingly, HDAC6 may be a promising target to mitigate negative reinforcement in alcohol use disorder (AUD). We ...
Short-Term Risk Stratification in Alcohol-Associated Hepatitis: Small HDL Particles and Inflammation Vulnerability Index Values Improve Model for End-Stage Liver Disease [0.03%]
酒精性肝炎短期风险分层：小HDLC颗粒和炎症脆弱指数改善终末期肝病模型评分
Eduardo Vilar-Gomez,Margery A Connelly,Vijay H Shah et al.
Eduardo Vilar-Gomez et al.
Background: Alcohol-associated hepatitis (AH) has high short-term mortality, whereas current prognostic models mainly reflect liver and renal dysfunction. The Metabolic Vulnerability Index (MVX) is a nuclear magnetic reso...
Quantitative Three-Dimensional Characterization of Facial Dysmorphism in Self-Identified African-American Individuals With Prenatal Alcohol Exposure [0.03%]
自我认同的非裔美国人在宫内接触酒精的面部畸形的三维定量表征
Qing Li,Zahra Mozaffarian,Hanie Moghaddasi et al.
Qing Li et al.
Background: The objective of this study was to characterize facial dysmorphology in a self-identified African-American cohort of children with prenatal alcohol exposure (PAE) and to evaluate the utility of computer vision...
Digital Cognitive Behavioral Therapy Reduces Heavy Drinking Among a Non-Treatment Sample of People With Alcohol Use Disorder: A Feasibility Trial With CBT4CBT [0.03%]
基于认知行为疗法的数字化戒酒方案对非治疗人群的效果：一项关于CBT4CBT的可行性试验研究
Anna Beth Parlier-Ahmad,Nicole Boss,Amber R Green et al.
Anna Beth Parlier-Ahmad et al.
Background: Most people with alcohol use disorder (AUD) do not receive treatment. Few digital evidence-based treatments have been tested among community-based samples of people with AUD. The present trial of Computer-Base...
Randomized Controlled Trial
Alcohol, clinical & experimental research. 2026 Aug;50(8):e70383. DOI:10.1111/acer.70383 2026
Alcohol-Induced Early-Stage Liver Injury Contributes to Increases in Voluntary Alcohol Intake and Cognitive Deficits in Mice [0.03%]
小鼠酒精性早期肝损伤增加自愿饮酒量和认知缺陷
Samantha G Skinner,Eliana G Aleman,Julio Rivera et al.
Samantha G Skinner et al.
Background: Liver-brain communication is increasingly recognized as a potential contributor to vulnerability to alcohol use disorder (AUD). However, the behavioral consequences of early alcohol-associated liver disease (A...
Association Between Alcohol Brief Intervention and Emergency Department and Inpatient Utilization Over 2 Years [0.03%]
酒精简短干预与急诊和住院利用率两年变化之间的关系
Andrew M Ballester,Felicia W Chi,Stacy A Sterling
Andrew M Ballester
Background: Brief Interventions (BIs) in primary care are an effective, evidence-based tool for reducing the cost and harm associated with unhealthy alcohol use. However, little is known about the impact of alcohol BIs on...
Observational Study
Alcohol, clinical & experimental research. 2026 Aug;50(8):e70395. DOI:10.1111/acer.70395 2026
Deciphering the Relationship Between Alcohol Consumption, Oropharyngeal Cancers, and Socioeconomic Determinants [0.03%]
酒精消耗、口腔咽部癌症和社会经济因素之间的关系探究
Tareq Al-Ahdal,Brenda Cabrera-Mendoza,Stefan Listl et al.
Tareq Al-Ahdal et al.
Background: Alcohol drinking is a major risk factor for oropharyngeal cancer, yet the nature of risk differences across drinking patterns remains unclear. ...
Alcohol Exposure Alters the Ghrelin System: In Vitro Mechanistic Insights Into Impaired Glucose Sensing and Enhanced Ghrelin Secretion [0.03%]
酒精暴露改变胃泌素系统：受损的葡萄糖感受和增强的胃泌素分泌的体内机制见解
Sundararajan Mahalingam,Ramesh Bellamkonda,Kusum K Kharbanda et al.
Sundararajan Mahalingam et al.
Background: Ghrelin, a stomach-derived orexigenic peptide, typically rises during fasting to stimulate food intake. Chronic alcohol consumption elevates circulating ghrelin, which induces alcohol craving and increases int...
Prenatal Alcohol and/or Tobacco Exposure, White-Matter Microstructure, and Cognition: Analyzing a South African Birth Cohort With Neurite Orientation and Dendrite Dispersion Imaging [0.03%]
孕期酒精和/或烟草暴露、白质微结构和认知：使用神经元形态取向和突触分散成像分析南非出生队列
Eric Kan,Andrew T Marshall,Deborah Jonker et al.
Eric Kan et al.
Background: Prenatal exposure to alcohol (PAE) and/or tobacco (PTE) may impact neurobiological and cognitive development years after such exposures have occurred. While such effects on cortical gray matter and cognition a...