Improved oncolytic and immunostimulatory activity of the spontaneous jin-3 reovirus mutant in preclinical bladder cancer models [0.03%]
改进jin-3重组重链变体的溶瘤和免疫刺激活性以治疗膀胱癌
Arjanneke F van de Merbel,Maaike H van der Mark,Lobke C M Hensen et al.
Arjanneke F van de Merbel et al.
Immunotherapy has emerged as a promising strategy for treatment of urothelial carcinoma of the bladder (UCB) but not all patients show clinically desirable responses upon treatment with immune-checkpoint inhibition. Oncolytic viruses may un...
Collagen depletion by pirfenidone enhances antitumor effect of oncolytic adenovirus against peritoneal metastases of gastric cancer [0.03%]
吡非尼东耗竭胶原蛋白可增强溶瘤腺病毒针对胃癌腹膜转移的抗肿瘤效果
Tomohiro Okura,Satoru Kikuchi,Hiroshi Tazawa et al.
Tomohiro Okura et al.
Cancer-associated fibroblasts (CAFs) play a crucial role in collagen accumulation, which develops and promotes peritoneal metastasis (PM) in gastric cancer (GC). In addition, the abundant stromal collagens in the tumor microenvironment func...
A facile chemical strategy to synthesize precise AAV-protein conjugates for targeted gene delivery [0.03%]
一种简便的化学策略合成精准的AAV-蛋白偶联物以进行靶向基因传递
Quan Pham,Jake Glicksman,Boyang Han et al.
Quan Pham et al.
Current adeno-associated virus (AAV) gene therapies are limited by a lack of tissue-specificity, leading to toxic off-target impacts and increased therapeutic costs. More target-specific AAV vectors can offer safer and less expensive therap...
Co-editing of NKG2A and FAS increases long-term cytotoxic capacity and persistence of CAR NK cells [0.03%]
NKG2A和FAS的共编辑可增强CAR-NK细胞的长期细胞毒能力和存活率
Juliane Mietz,Lukas Egli,Meike Misiune et al.
Juliane Mietz et al.
Natural killer (NK) cells have the intrinsic ability to kill cancer cells and are thus targeted in immunotherapy. Anti-CD19 CAR NK cells have shown efficacy in clinical studies in treating B cell malignancies; however, the full cytotoxic ca...
Survivin/BIRC5-derived peptide disrupts survivin dimerization and cell division and induces multifaceted anti-cancer effects [0.03%]
Survin 抑制性肽通过干扰 Survin 二聚化和细胞分裂产生多靶向抗癌效应
Manikandan Santhanam,Venkatadri Babu,Anna Shteinfer-Kuzmine et al.
Manikandan Santhanam et al.
Survivin, a homodimeric protein overexpressed in virtually all cancers, is largely absent in non-proliferating adult tissues. It is a multifunctional regulator of cellular homeostasis that plays critical roles in proliferation, apoptosis, a...
Target choice and exon skipping regulate CRISPR-directed gene editing of NRF2 in head/neck and esophageal cancer cells [0.03%]
靶点选择和外显子跳跃调节CRISPR定向编辑头颈部及食道癌细胞中的NRF2基因
Natalia Rivera-Torres,Lauren E Skelly,John A Rogowskyj et al.
Natalia Rivera-Torres et al.
Head and neck cancer (HNC) is the seventh most diagnosed cancer, with a predicted 30% increase annually by 2030. Conventional treatment is often combinatorial involving chemotherapy and radiation therapy, immunotherapy, and surgery, but ove...
Rhabdoid tumors as a novel target for PSMA-directed CAR T cell therapy [0.03%]
视网膜母细胞瘤作为PSMA定向CAR-T细胞治疗的新靶点
Aroshi Mitra,Tianyi Zhou,Jacky Wu et al.
Aroshi Mitra et al.
Rhabdoid tumor is an ultra-rare and highly aggressive pediatric malignancy with a poor prognosis and limited therapeutic options. To identify novel immunotherapeutic targets, transcriptomic data from the Cancer Cell Line Encyclopedia were a...
Virus-based IFNγ gene delivery and photodynamic therapy cooperate to remodel the tumor microenvironment and suppress breast cancer [0.03%]
基于病毒的IFNγ基因输送和光动力疗法协同重塑肿瘤微环境并抑制乳腺癌进展
Ksenija Korotkaja,Zhanna Rudevica,Darija Lapina et al.
Ksenija Korotkaja et al.
This study demonstrates a potent synergistic anti-tumor effect of photodynamic therapy (PDT) based on chlorin e6 (Ce6) combined with Semliki Forest virus-mediated IFNγ (SFV/IFNγ) delivery in 4T1 mouse breast cancer model. We demonstrate t...
Simin Manole,Neil S Forbes
Simin Manole
We have created a recombinant form of calreticulin (CALR) to serve as an immune adjuvant. For many patients with immunogenically cold tumors, immunotherapies are ineffective. Simulating immunogenic cell death with damage-associated molecula...
Oncolytic adenoviruses encoding bispecific T cell engagers or a novel trispecific T cell engager for dual-targeting of c-MET and EGFR [0.03%]
编码双特异性T细胞接合物或新型三特异性T细胞接合物的溶瘤腺病毒，用于c-MET和EGFR的双重靶向治疗
Martin A Boos,Oliver Seifert,Stefanie Sawall et al.
Martin A Boos et al.
This study reports a strategy to overcome immune escape of tumors during viro-immunotherapy due to tumor heterogeneity. We pursued a dual-targeting approach of epidermal growth factor receptor (EGFR) and cellular mesenchymal epithelial tran...