End-repair causes methylation underestimation in cell-free DNA sequencing libraries [0.03%]
末端修复导致无细胞DNA测序库甲基化低估
Tobin E Groth,Andrew A Mishin,Varsha Rao et al.
Tobin E Groth et al.
Cell-free DNA methylation sequencing provides insight into tissue of origin and chromatin structure. In some workflows, generating libraries includes end-repair. Using matched single-stranded and double-stranded libraries prepared from the ...
Liquid biopsy in Oncology: Results of a Delphi consensus study endorsed by the AIOM-SIAPEC/IAP-SIBioC-SIF Italian scientific societies [0.03%]
意大利医学学会(AIOM)-肿瘤内科专家协会(SIAPEC/IAP)-生物标志物与转化研究委员会(SIBioC)-病理生理学会(SIF)支持的液体活检在肿瘤学中的应用：德尔菲共识研究结果
Valerio Gristina,Umberto Malapelle,Gennaro Daniele et al.
Valerio Gristina et al.
Liquid biopsy (LB) offers a minimally invasive alternative to tissue biopsy by detecting tumor-derived analytes in biological fluids. Nonetheless, its adoption is limited by variability in methodologies. Therefore, this study used a modifie...
General practitioners' attitudes towards liquid biopsy as a diagnostic test for advanced lung cancer [0.03%]
全科医生对液体活检作为肺癌诊断检测的态度
Danyon Lo,Jenny Wong,Rawiri Keenan et al.
Danyon Lo et al.
Background: In New Zealand (NZ), lung cancer disproportionately affects our indigenous Māori population, with both incidence and mortality being three times higher than NZ Europeans. Incidence of endothelial growth facto...
Circulating tumour DNA (ctDNA) as a predictor of progression-free and overall survival in non-resectable pancreatic cancer: a systematic review and meta-analysis [0.03%]
循环肿瘤DNA(ctDNA)在不可切除胰腺癌患者中无进展生存和总生存的预后价值：系统评价和Meta分析
Mette M Steiniche,Louise B Callesen,Elizabeth H Vlk et al.
Mette M Steiniche et al.
Background: This systematic review and meta-analysis synthesised current evidence on circulating tumour DNA (ctDNA) for predicting clinical outcomes in patients with non-resectable pancreatic ductal adenocarcinoma (PDAC)....
Corrigendum to "Chemotherapy response monitoring with DNA methylation-based ctDNA tumor fraction: Evidence from a real-world cohort of patients with advanced common solid malignancies" [J Liq Biopsy, 10 (2025), 100442] [0.03%]
关于“基于DNA甲基化ctDNA肿瘤分数的化疗反应监测：来自晚期常见实体瘤患者真实世界队列的证据”的勘误[J液生物标志物，10 (2025)，100442]
Christian D Rolfo,Moh&#x;d M Khushman,Alessandro Russo et al.
Christian D Rolfo et al.
[This corrects the article DOI: 10.1016/j.jlb.2025.100442.]. © 2025 The Author(s).
Published Erratum
The journal of liquid biopsy. 2025 Nov 25:10:100448. DOI:10.1016/j.jlb.2025.100448 2025
Cerebrospinal fluid ctDNA clarifies clonal divergence: leptomeningeal flare of EGFR-mutant disease after switch to selpercatinib for acquired RET fusion [0.03%]
脑脊液ctDNA阐明了克隆分化：在获得性RET融合后切换至selpercatinib后的EGFR突变疾病蛛网膜下腔复发
Kei Kunimasa,Motohiro Tamiya,Takako Inoue et al.
Kei Kunimasa et al.
Liquid biopsy can expose spatially segregated resistance biology that is invisible to single-site tissue testing, particularly across the blood-brain barrier. We report how cerebrospinal fluid (CSF) circulating tumor DNA (ctDNA) clarified t...
Cancer in a drop: Liquid biopsy highlights from the World Conference on Lung Cancer (WCLC) 2025 [0.03%]
一管见肿瘤：2025年世界肺癌大会(WCLC)液体活检研究亮点
Nadia Ghazali,Ana Ortega-Franco,Diego de Miguel-Perez et al.
Nadia Ghazali et al.
The role of liquid biopsy in oncological care continues to expand, with multiple studies presented at the International Association for the Study of Lung Cancer (IASLC) 2025 World Conference on Lung Cancer (WCLC 2025). This review summarize...
An innovative nuclear antigen-based approach for single-cell isolation of circulating tumor cells in adrenal cortical carcinoma [0.03%]
一种创新的核抗原为基础的方法用于肾上腺皮质癌循环肿瘤细胞的单细胞分离
Giulia Cantini,Francesca Salvianti,Roberta Armignacco et al.
Giulia Cantini et al.
Adrenal cortical carcinoma (ACC) is a rare and aggressive endocrine tumor that originates from the adrenal cortex. Radical tumor resection remains the most effective therapy since survival dramatically drops when metastases are present at d...
Circulating tumor DNA as part of the routine work-up for patients with suspected advanced lung cancer [0.03%]
循环肿瘤DNA检测作为疑似晚期肺癌患者的常规检查项目之一
Emma Holjak,Tia Brasoveanu,Saurav Verma et al.
Emma Holjak et al.
Liquid biopsy (LB) is a useful tool in patients with advanced non-small cell lung cancer (aNSCLC) to detect actionable molecular alterations and thereby allow genotype-matched therapies. Currently, LB is recommended for individuals diagnose...
Chemotherapy response monitoring with DNA methylation-based ctDNA tumor fraction: Evidence from a real-world cohort of patients with advanced common solid malignancies [0.03%]
基于DNA甲基化检测ctDNA肿瘤分数评估晚期实体瘤患者化疗疗效：来自真实世界队列的证据
Christian D Rolfo,Moh&#x;d M Khushman,Alessandro Russo et al.
Christian D Rolfo et al.
Background/objectives: Chemotherapy remains standard for many cancers, but challenges remain in evaluating clinical response to therapy. Epigenomic circulating tumor DNA (ctDNA) quantification is an emerging molecular app...