Microfluidic investigation for shear-stress-mediated repair of dysglycemia-induced endothelial cell damage [0.03%]
剪切应力介导的微流体技术在修复高血糖诱导的内皮细胞损伤中的作用研究
Si-Yu Hu,Chun-Dong Xue,Yong-Jiang Li et al.
Si-Yu Hu et al.
Dysglycemia causes arterial endothelial damage, which is an early critical event in vascular complications for diabetes patients. Physiologically, moderate shear stress (SS) helps maintain endothelial cell health and normal function. Reacti...
Yueming Xu,Huanhuan Xu,Jie Yan et al.
Yueming Xu et al.
Among the various families of G protein-couple receptors (GPCR), the adhesion family of GPCRs is specialized by its expansive extracellular region, which facilitates the recruitment of various ligands. Previous hypothesis proposed that aGPC...
Xinyu Hu,Min Bao
Xinyu Hu
Micropatterning is a sophisticated technique that precisely manipulates the spatial distribution of cell adhesion proteins on various substrates across multiple scales. This precise control over adhesive regions facilitates the manipulation...
Mechanobiomaterials: Harnessing mechanobiology principles for tissue repair and regeneration [0.03%]
机械生物材料：利用机械生物学原理进行组织修复和再生
Xiao Lin,Hua Yang,Yi Xia et al.
Xiao Lin et al.
Mechanical stimuli are known to play critical roles in mediating tissue repair and regeneration. Recently, this knowledge has led to a paradigm shift toward proactive programming of biological functionalities of biomaterials by leveraging m...
Mechanotransduction in distinct F-actin architectures: a novel molecular tension sensor revealing cellular mechanical anisotropy [0.03%]
不同F-肌动蛋白体系结构中的机械转导：一种揭示细胞机械各向异性的新型分子张力传感器
Ting Liang,Bin Li
Ting Liang
Mechanotransduction is essential for cell fate and behavior, and F-actin plays a key role in the generation and transmission of molecular forces. A recent study published in Nature Communication presented a novel high-precision molecular te...
Mechanobiology of Type 1 hypersensitivity: Elucidating the impacts of mechanical forces in allergic reactions [0.03%]
I型超敏反应的力学生物学：阐明机械力在过敏反应中的影响
Henry Sutanto
Henry Sutanto
Type 1 hypersensitivity involves an exaggerated immune reaction triggered by allergen exposure, leading to rapid release of inflammatory mediators. Meanwhile, mechanobiology explores how physical forces influence cellular processes, and rec...
Advances in modeling cellular mechanical perceptions and responses via the membrane-cytoskeleton-nucleus machinery [0.03%]
细胞膜-细胞质骨架-细胞核机械感知及响应机制的研究进展
Hongyuan Zhu,Run Miao,Jin Wang et al.
Hongyuan Zhu et al.
Mechanical models offer a quantitative framework for understanding scientific problems, predicting novel phenomena, and guiding experimental designs. Over the past few decades, the emerging field of cellular mechanobiology has greatly benef...
Mechanical impact on biomineralization: Enhancing the strength of composite materials [0.03%]
机械对生物矿化的影响：增强复合材料的强度
Xufeng Niu,Chunyang Ma,Yubo Fan
Xufeng Niu
A recent study published in Nature Communications introduces a novel mechanically-mediated reaction involving ZnO nanoparticles that autonomously react, forming Zn/S mineral microrods within an organogel. These microrods selectively reinfor...
Kai Huang,Yingxin Qi
Kai Huang
The 2024 Nobel Prize in Physiology or Medicine has once again sparked considerable interest in microRNA (miRNA). Recent advances have unveiled that miRNAs play critical roles in mediating the effects of mechanical stimuli on gene expression...
In vivo analysis of hybrid hydrogels containing dual growth factor combinations, and skeletal stem cells under mechanical stimulation for bone repair [0.03%]
含有双重生长因子组合的杂化水凝胶及机械刺激下骨髓基质干细胞的体内分析用于骨修复
David Gothard,Michael Rotherham,Emma L Smith et al.
David Gothard et al.
Bone tissue engineering requires a combination of materials, cells, growth factors and mechanical cues to recapitulate bone formation. In this study we evaluated hybrid hydrogels for minimally invasive bone formation by combining biomateria...