Tingting Li,Yiyao Liu
Tingting Li
The cardiac vasculature is characterized by high pressure, high blood flow, and dense vascular branching, which may increase its exposure to circulating tumor cells (CTCs). However, both primary cardiac tumors and metastases are remarkably ...
Mechanobiology of hypertrophic chondrocyte mineralization: Biomechanical regulation and therapeutic implications in skeletal disorders [0.03%]
肥大软骨细胞矿化 mechanobiology及其在骨骼疾病治疗中的作用机制和意义
Yuhao Liu,Guangyu Xu,Yi Shen et al.
Yuhao Liu et al.
Chondrocyte proliferation, differentiation and hypertrophic mineralization are central events that guide subsequent vascular invasion and bone replacement processes. This process is controlled by a sophisticated molecular network including ...
Shi-Lei Xue
Shi-Lei Xue
Embryogenesis is governed by diverse physical forces, yet how these forces coordinate with biochemical signals to ensure reproducible morphogenesis remains poorly understood. Using the developing vertebrate intestine as a model, recent stud...
Substrate pre-stretch reprograms macrophage behavior through surface topographical remodeling [0.03%]
基材预拉伸通过表面形貌重修程序巨噬细胞行为
Gang Yang,Yi Han,Tao Tang et al.
Gang Yang et al.
Mechanical regulation of macrophages is increasingly recognized, but whether a mechanically preconditioned surface remains biologically instructive after loading has ceased is unclear. Here, we developed a custom uniaxial pre-stretch device...
Mechanosensitive reactive oxygen Species:A precision medicine target for oxidative stress-related diseases [0.03%]
机械敏感型反应性氧类物质：与氧化应激相关疾病的精准医疗靶标
Kai Huang
Kai Huang
Oxidative stress induced by abnormal mechanical stress is a common pathological mechanism underlying the initiation and progression of various injury and diseases. Mechanosensitive reactive oxygen species (mechano-ROS), a subset of ROS spec...
Viscous drag-induced self-regeneration of laser-dissected actin stress fibers: A potential mechanism for mechanical memory [0.03%]
激光解剖肌动蛋白应力纤维引起的黏性拖拽诱导的自再生作用：机械记忆的一种潜在机制
Kazuaki Nagayama
Kazuaki Nagayama
Biological tissues are constantly subjected to physiological mechanical stresses that can induce microdamage to cellular components, a process linked to cellular aging and carcinogenesis. Actin stress fibers (SFs) are central to maintaining...
Numerical analysis of three-dimensional middle ear and inner ear based on nonlinear and viscoelastic constitutive relations [0.03%]
基于非线性黏弹性本构关系的三维中耳和内耳数值分析研究
Wenjuan Yao,Jiakun Wang,Junhua Ye
Wenjuan Yao
Hearing is a critical sensory function for humans, and the dynamic behavior of the human ear is influenced by its constitutive relation. In this paper, a finite element model (FEM) of the middle ear with a nonlinear constitutive relation an...
Stacked human aortic endothelial cells induce atherosclerotic fatty streaks and release proinflammatory cytokines and chemokines [0.03%]
人主动脉内皮细胞的堆叠诱导动脉粥样硬化斑块并释放促炎性细胞因子和趋化因子
Ye Zeng,Zhi Ouyang,Yan Qiu et al.
Ye Zeng et al.
Fatty streaks, one of the earliest signs of atherosclerosis, comprise lipid-laden foam cells, which are traditionally thought to be derived from circulating monocytes that have infiltrated through the leaky endothelium and from vascular smo...
Tumor microenvironment and mechanotransduction pathways: Novel targets and new directions for cancer therapy [0.03%]
肿瘤微环境和机械转导通路：癌症治疗的新靶点和新方向
Xinjie Zhang,Jian Sun,Zhengjian Li et al.
Xinjie Zhang et al.
In cancer research, the extracellular matrix (ECM) of the tumor microenvironment (TME) was once regarded as a mere passive structural scaffold for tumor tissue, while the biomechanical cues generated by its dynamic physical remodeling have ...
Biomechanical analysis of lumbar oblique manipulation for lumbar disc herniation with different protrusion subtypes [0.03%]
不同类型腰椎间盘突出症侧板腰操作手法的生物力学分析
Linling Zhang,Zhen Deng,Xuanzong Zhang et al.
Linling Zhang et al.
Lumbar oblique manipulation (LOM) is one of the commonly used conservative treatments for lumbar disc herniation (LDH). Compared with surgical interventions, its non - invasive nature provides patients with greater comfort and reduces treat...