A tailored fit: How intermediate filaments orchestrate glioblastoma invasion [0.03%]
巧妙配合：中间丝如何协调胶质母细胞瘤的侵袭
Jessy V van Asperen,Elly M Hol
Jessy V van Asperen
Glioblastoma (GBM) is a highly invasive tumour. Invasion of GBM cells into the densely packed brain parenchyma reflects a profound mechanobiological adaptation to the mechanical constraints of the brain. A recent study by van Bodegraven et ...
Penicillin-streptomycin influences macrophage mechanical properties and microenvironment mechano-sensation [0.03%]
青霉素-链霉素影响巨噬细胞的机械性能及微环境力学感知
Shiqi Hu,Buwei Hu,Jing Yang et al.
Shiqi Hu et al.
Penicillin-streptomycin (pen-strep) is routinely included in cell culture media, yet its impact on macrophage mechanics has not been systematically examined. Here, we show that pen-strep treatment increases macrophage stiffness in a time-de...
Cheng Zhu
Cheng Zhu
The immune system relies on intricate molecular interactions and cellular signaling to discriminate between self and non-self, mount appropriate responses to pathogens and cancer, and maintain tissue homeostasis to avoid autoimmune diseases...
Mechano-regulation of cancer cell memory in tumor progression and therapy [0.03%]
肿瘤发展和治疗中的癌细胞记忆的力学调节
Yunjia Qu,Jiaxin Cui,Zhuohang Wu et al.
Yunjia Qu et al.
Cancer cell memory, the ability to retain responses to prior environmental stimuli, has emerged as a key driver of tumor progression, therapeutic resistance, and immune evasion. Mechanical cues within the tumor microenvironment (TME), inclu...
Mechanical cues enhance chondrocyte function: Insights from mechanoreception, regulation, and biological responses [0.03%]
力学刺激增强软骨细胞功能：来自机械感受、调控和生物学反应的见解
Gaige Wu,Shuai Chen,Qian Li et al.
Gaige Wu et al.
Chondrocytes, the sole cell type in articular cartilage, are responsible for synthesizing and maintaining the primary components of the extracellular matrix (ECM). In daily life, chondrocytes are subjected to diverse mechanical stimuli, and...
Mechanobiology of intervertebral disc degeneration: From pathological mechanisms to therapeutic approaches [0.03%]
椎间盘退变的力学生物学：从病理机制到治疗手段
Han Qiao,Kai Zhang,Jie Zhao
Han Qiao
Intervertebral disc degeneration (IVDD) is a complex mechanobiological process driven by abnormal mechanical loading, resulting in structural failure, inflammatory activation, and cellular dysfunction. Understanding these mechanobiological ...
A practical protocol of processing mineralized tissue for Visium spatial transcriptomics [0.03%]
适用于Visium空间转录组学的矿化组织处理实用方案
Jixing Miao,Mingjie Ma,Yuhan Guo et al.
Jixing Miao et al.
Spatial transcriptomics analysis of mineralized tissues faces significant challenges due to lengthy decalcification procedures that severely compromise RNA integrity and subsequent gene detection. This protocol details an optimized workflow...
Magnesium-containing implants enhance bone healing: A mechanobiological perspective [0.03%]
含镁植入物促进骨愈合：力学生物学角度视角
Zhenkang Wen,Lei Lei,Haozhi Zhang et al.
Zhenkang Wen et al.
Unlike traditional implants primarily composed of bioinert materials, magnesium (Mg) -a degradable biomaterial - offers significant promise for next-generation bone healing implants, whether utilized as a primary structural component or a s...
Qifan Yu,Yudong Duan,Zhuang Zhu et al.
Qifan Yu et al.
Mechanical microenvironment of each tissue plays an important role in regulating its special cellular behaviors, such as morphology, proliferation, differentiation, and migration. Mechanical signals can direct lineage specification or promo...
Synthetic mechanoreceptor engineering: From genetic encoding to DNA nanotechnology-based reprogramming [0.03%]
合成机械感受器工程：从基因编码到基于DNA纳米技术的重新编程
Sihui Yang,Zhou Nie
Sihui Yang
Precise modulation of mechanoreceptor-mediated signal transduction is crucial for decoding cellular mechanotransduction mechanisms and programming cell fate. This review provides a comprehensive summary of recent advances in engineering syn...