Covalent organic framework-based nanoplatforms with tunable mechanical properties for drug delivery and cancer therapy [0.03%]
基于可调机械性能的共价有机骨架纳米平台用于药物递送和癌症治疗
Liefeng Hu,Yonggang Lv
Liefeng Hu
Covalent organic frameworks (COFs) are emerging crystalline porous materials composed of covalently linked and periodically arranged organic molecules, which exhibit mechanical properties mediated by structural diversity. Meanwhile, the tun...
Mengjiao Hua,Yu Wu
Mengjiao Hua
Tumor state transitions between the excited (high-concentration) and nonexcited (low-concentration) basins under the Gaussian white noise and non-Gaussian colored noise are investigated via the most probable steady states (MPSS) and the fir...
Yi-Xian Qin,Jie Zhao
Yi-Xian Qin
The use of mechanical biology and biomechanical signal transduction is a novel approach to attenuate biological tissue degeneration, whereas the understanding of specific cellular responses is critical to delineate the underlying mechanism....
Patient-derived tumor models and their distinctive applications in personalized drug therapy [0.03%]
基于患者的肿瘤模型及其在个性化药物治疗中的独特应用
Jia He,Chunhe Zhang,Alican Ozkan et al.
Jia He et al.
Tumor models in vitro are conventional methods for developing anti-cancer drugs, evaluating drug delivery, or calculating drug efficacy. However, traditional cell line-derived tumor models are unable to capture the tumor heterogeneity in pa...
In silico study unfolds inhibitory potential of epicatechin gallate against SARS-CoV-2 entry and replication within the host cell [0.03%]
基于计算的研究揭示表没食子儿茶素具有抑制SARS-CoV-2进入和在宿主细胞内复制的潜力
Prem Rajak,Abhratanu Ganguly
Prem Rajak
Coronavirus disease-19 (COVID-19) is the ongoing pandemic affecting millions of people worldwide. Several vaccine candidates have been designed and developed for the causative virus, SARS-CoV-2. However high mutation rate in the viral genom...
Extracellular cell matrix stiffness-driven drug resistance of breast cancer cells via EGFR activation [0.03%]
乳腺癌细胞通过EGFR活化由细胞外基质刚性驱动的药物抗性
Tingting Li,Yichao Li,Hao Wu et al.
Tingting Li et al.
Tumor progression is accompanied by complex structural changes in the extracellular matrix (ECM), which decrease the effective exposure of tumors to drugs. Breast cancer are highly heterogeneous with a typically high degree of ECM remodelin...
Zhao Xu,Feng Xu,Bo Cheng
Zhao Xu
Cellular behaviors such as migration, spreading, and differentiation arise from the interplay of cell-matrix interactions. The comprehension of this interplay has been advanced by the motor-clutch model, a theoretical framework that capture...
Tug of war: Understanding the dynamic interplay of tumor biomechanical environment on dendritic cell function [0.03%]
拉锯战：理解肿瘤生物力学环境对树突细胞功能动态相互作用的影响
Brian Chesney Quartey,Gabriella Torres,Mei ElGindi et al.
Brian Chesney Quartey et al.
Dendritic cells (DCs) play a pivotal role in bridging the innate and adaptive immune systems. From their immature state, scavenging tissue for foreign antigens to uptake, then maturation, to their trafficking to lymph nodes for antigen pres...
From sequence to mechanobiology? Promises and challenges for AlphaFold 3 [0.03%]
从序列到机械生物学？AlphaFold 3 的前景与挑战
Francesco Zonta,Sergio Pantano
Francesco Zonta
Interactions between macromolecules orchestrate many mechanobiology processes. However, progress in the field has often been hindered by the monetary and time costs of obtaining reliable experimental structures. In recent years, deep-learni...
A microbiome-dependent gut-bone axis determines skeletal benefits from mechanical loading [0.03%]
依赖微生物组的肠骨轴决定了机械加载的骨骼益处
X Edward Guo
X Edward Guo
A recent study published in Cell Metabolism entitled "Gut microbial alterations in arginine metabolism determine bone mechanical adaptation" demonstrated that administration of L-arginine enhanced bone mechanical adaptation by activating a ...