Ting Jiang,Meng-Ting Zheng,Ruo-Mei Li et al.
Ting Jiang et al.
Bone and immune cells typically inhabit the same microenvironment and engage in mutual interactions to collectively execute the functions of the "osteoimmune system." Establishing a harmonized and enduring osteoimmune system significantly e...
Tropomodulin1 regulates the biomechanical changes in macrophages induced by matrix stiffness [0.03%]
肌张力蛋白1调节基质刚度诱导的巨噬细胞生物力学变化
Yajun Meng,Amannisa Tuersuntuoheti,Siyu Jiang et al.
Yajun Meng et al.
The monocyte/macrophage infiltration plays critical roles in the development of atherosclerosis. Arterial stiffness is a cholesterol-independent risk factor for cardiovascular events. The regulation of arterial stiffness on biomechanics of ...
Gut microbiota-derived butyrate enhances exercise-induced bone mineral density in humans [0.03%]
肠道微生物群衍生的丁酸盐增强运动引起的骨矿密度提升作用于人体内
Xiangya Dou,Pengyu Fu,Yuting Zhang et al.
Xiangya Dou et al.
Bone Mineral Density (BMD) is one of the primary markers of bone health. Exercise provides constant mechanical stress to bone, which in turn increases BMD. Gut-bone axis is considered to play an important role in the regulation of exercise ...
Overstretch causes lipid accumulation in vascular smooth muscle cells dependent on NADPH oxidase 1 [0.03%]
氧化应激通过Nox1依赖性机制诱导血管平滑肌细胞中脂质积累及泡沫化形成
Jiazhen Zhang,Qinfen Li,Suoqi Ding et al.
Jiazhen Zhang et al.
At the bend and bifurcation of arteries prone to atherosclerosis, pulsatile blood retention may cause overstretch on the tube wall. It has been reported that more than half of the foam cells found in atherosclerotic plaques are derived from...
Swimming induces bone loss via regulating mechanical sensing pathways in bone marrow [0.03%]
游泳通过调节骨髓机械感受途径诱导骨丢失
Shaotian Fu,Yahong Lu,Wenkun Sun et al.
Shaotian Fu et al.
Bone is an organ capable of perceiving external mechanical stress in real time and responding dynamically via mechanosensing proteins such as Piezo1 and YAP/TAZ. Upon sensing the mechano-signals, cells within the bone matrix collaborate to ...
Biomechanics of horizontal meniscus tear and healing during knee flexion: Finite element analysis [0.03%]
膝关节屈曲时水平半月板撕裂和愈合的生物力学：有限元分析
Bingtong Yan,Minmin Lin,Yang Liu et al.
Bingtong Yan et al.
Meniscus horizontal tear is a common injury that mostly occurs in middle-aged and elderly people, and the effect of repair surgery directly affects the functional recovery of the knee joint and prevention of degenerative joint diseases. How...
Prognostic assessment of osteolytic lesions and mechanical properties of bones bearing breast cancer using neural network and finite element analysis☆ [0.03%]
基于神经网络和有限元分析的乳腺癌骨转移病灶预后及机械性能评估研究
Shubo Wang,Tiankuo Chu,Murtaza Wasi et al.
Shubo Wang et al.
The management of skeletal-related events (SREs), particularly the prevention of pathological fractures, is crucial for cancer patients. Current clinical assessment of fracture risk is mostly based on medical images, but incorporating seque...
The underlying difference of metastatic and non-metastatic breast cancer cells in configuring type I collagen fibres to promote migration by cell mechanics [0.03%]
乳腺癌细胞通过细胞力学配置I型胶原纤维促进迁移的内在差异性研究非转移性和转移性乳腺癌细胞的区别
Mingxing Ouyang,Weihui Chen,Ting Zhou et al.
Mingxing Ouyang et al.
The progression of tumors is heavily influenced by mechanical properties of their microenvironment. In this work, we applied micropatterned models with varying distances and shapes to investigate the differences between metastatic MDA-MB-23...
Multidimensional excavation of the current status and trends of mechanobiology in cardiovascular homeostasis and remodeling within 20 years [0.03%]
二十年来心血管稳态和重塑中机械生物学的现状及趋势的多维度挖掘
Wei Liao,Yuxi Huang,Xiangxiu Wang et al.
Wei Liao et al.
Mechanobiology is essential for cardiovascular structure and function and regulates the normal physiological and pathological processes of the cardiovascular system. Cells in the cardiovascular system are extremely sensitive to their mechan...
Matrix stiffness-driven cancer progression and the targeted therapeutic strategy [0.03%]
基质硬度驱动的癌症进展及靶向治疗策略
Rui Liang,Guanbin Song
Rui Liang
Increased matrix stiffness is a common phenomenon in solid tumor tissue and is regulated by both tumor and mesenchymal cells. The increase in collagen and lysyl oxidase family proteins in the extracellular matrix leads to deposition, contra...