Stiffness matters: A soft bone marrow organoid rejuvenates hematopoietic stem cells [0.03%]
硬度很重要：柔软的骨髓类器官可使造血干细胞恢复活力
Xiaoying Zhang,Rui Yue
Xiaoying Zhang
A recent study published in Cell Stem Cell [1] showed that matrix stiffness critically regulates hematopoietic stem cell (HSC) niche, and successfully engineered a soft bone marrow (BM) organoid to maintain and rejuvenate HSCs ex vivo. In a...
Jiake Xu
Jiake Xu
Mechanotransduction, the transfer of mechanical stimuli into various biological signals, is a vital biological process in multiple organ systems. The osteoclast (OC) plays a vital role in bone metabolism and repair. The role of mechanotrans...
Extracellular matrix stiffness modulates the mechanophenotypes and focal adhesions of colon cancer cells leading to their invasions via YAP1 [0.03%]
细胞外基质刚度通过YAP1调控结直肠癌细胞的力学表型及焦粘连导致肿瘤侵袭转移
Kaide Xia,Wenhui Hu,Yun Wang et al.
Kaide Xia et al.
Distal metastasis is the main cause of clinical treatment failure in patients with colon cancer. It is now known that the invasion and metastasis of cancer cells is precisely regulated by chemical and physical factors in vivo. However, the ...
Mechanotransduction in subchondral bone microenvironment and targeted interventions for osteoarthritis [0.03%]
软骨下骨微环境力学生化转化及关节炎靶向干预措施研究进展
Rui Feng,Wenhui Hu,Yuheng Li et al.
Rui Feng et al.
Osteoarthritis (OA) is a progressive degenerative joint sickness related with mechanics, obesity, ageing, etc., mainly characterized by cartilage degeneration, subchondral bone damage and synovium inflammation. Coordinated mechanical absorp...
Rescuing SERCA2 pump deficiency: A novel approach to improve bone mechano-responsiveness in type 2 diabetes [0.03%]
挽救SERCA2泵功能缺陷：改善2型糖尿病患者骨骼力学反应性的新方法
Zhifeng Yu,X Edward Guo
Zhifeng Yu
A recent study published in Nature Communications demonstrated that restoring SERCA2 pump deficiency can enhance bone mechano-responsiveness in type 2 diabetes (T2D) by modulating osteocyte calcium dynamics. The findings revealed that in T2...
Probing the protrusions: lamellipodia and filopodia in cancer invasion and beyond [0.03%]
肿瘤浸润及其他领域的伪足研究：粘附斑和丝状伪足的作用机制探究
Laras Pratiwi,Elisa Elisa,Henry Sutanto
Laras Pratiwi
The dynamic protrusions of lamellipodia and filopodia have emerged as crucial players in tumor progression and metastasis. These membrane structures, governed by intricate actin cytoskeletal rearrangements, facilitate cancer cell migration,...
Tom M J Evers,Joep Beumer,Hans Clevers et al.
Tom M J Evers et al.
The gastrointestinal (GI) tract's primary role is food digestion, relying on coordinated fluid secretion and bowel movements triggered by mechanosensation. Enteroendocrine cells (EECs) are specialized mechanosensitive cells that convert mec...
Bead-based microfluidic platforms for multiplex and ultrasensitive immunoassays in clinical diagnosis and treatment [0.03%]
临床诊断与治疗中用于多重和超高灵敏度免疫测定的微流控平台
Xiaoxia Fang,Yiwen Yang,Heni Wang et al.
Xiaoxia Fang et al.
Multiplex ultrasensitive detection of low abundance proteins remains a significant challenge in clinical applications, necessitating the development of innovative solutions. The integration of bead-based microfluidic chip platforms with the...
Xiaodan Zhao,Yanqige Jiang,Yu Zhou et al.
Xiaodan Zhao et al.
The significance of early detection and isolation of infected individuals, along with the quantitative assessment of antibodies against the virus, has gained widespread recognition during the ongoing covid-19 pandemic. This necessitates the...
Regulatory role of interfacial adhesion and mechanical microenvironments in microbe-host interactions [0.03%]
界面粘附和机械微环境在微生物-宿主相互作用中的调节作用
Yuting Feng,Jianyong Huang
Yuting Feng
A recent study published in Nature Communications showed that essential modulatory roles of interfacial adhesion and mechanical microenvironments such as geometric constraints and extracellular matrix stiffness, in microbe-host cell interac...