Early diabetes screening via red blood cell mechanics using microfluidic chip integration [0.03%]
基于微流控芯片的红细胞力学检测新技术有望成为糖尿病早期筛查手段
Yibo Feng,Bingchen Che,Yonggang Liu et al.
Yibo Feng et al.
Early diagnosis of diabetes is crucial, as diabetes, particularly type 2, can eventually lead to irreversible changes and complications. Conventional techniques, such as the Fasting Plasma Glucose (FPG) Test and Hemoglobin A1c (HbA1c) Test,...
Kaiyang Wang,Shuhui Ren,Yunfang Jia et al.
Kaiyang Wang et al.
The modern medical field faces two critical challenges: the dramatic increase in data complexity and the explosive growth in data size. Especially in current research, medical diagnostic, and data processing devices relying on traditional c...
High-rate mechano-stimulation alters proliferation- and maturation-related signaling of oligodendrocyte precursor cells in a 3D hydrogel [0.03%]
高频率力学刺激可改变少突胶质前体细胞在三维水凝胶中增殖和分化的信号通路
Ryosuke Yokosawa,Rachel A Mazur,Kelsey A Wilson et al.
Ryosuke Yokosawa et al.
Traumatic brain injury (TBI) leads to neuroinflammation and is associated with chronic neurodegeneration. Many TBI studies aim to understand further the mechanism by which cells in the brain respond to the mechanical forces associated with ...
The sex-specific effects of RAGE signaling and type 2 diabetes on mouse cortical bone mechanics, structure, and material properties [0.03%]
RAGE信号通路和2型糖尿病对小鼠皮质骨力学、结构和材料特性性别差异的影响
Timothy Hung,Kaitlyn S Broz,Remy E Walk et al.
Timothy Hung et al.
Individuals with type 2 diabetes (T2D) are prone to fracture at numerous skeletal sites despite presenting with a higher bone mineral density (BMD). The accumulation of Advanced Glycation End-products (AGEs) in the bone tissues of patients ...
Beyond biochemical patterning: How mechanical bistability governs robust organoid morphogenesis [0.03%]
超越生化模式：机械双稳态如何调控器官体发生发育的稳健性
Qigan Gao,Yuehua Yang,Haoxiang Yang et al.
Qigan Gao et al.
Understanding the regulatory mechanisms of intestinal organoid morphogenesis remains a fundamental challenge in organoid biology. Emerging evidence highlights mechanical bistability as a critical regulator, mediated by dynamic lumen-actomyo...
Mechanosensitive nuclear checkpoint: nuclear envelope as a sensor of chromosomal instability and driver of cell fate [0.03%]
机械敏感型核检查点：核膜作为染色体不稳定传感器和细胞命运驱动因素
Chenyang Ji,Junwei Chen,Fuxiang Wei
Chenyang Ji
The nuclear envelope (NE) is a dynamic, mechanosensitive structure that functions as a protective barrier for the genome and serves as a checkpoint responding to external stimuli. It plays a critical role in maintaining genomic stability an...
Topographical cues of biomaterials and fibroblast activation: Are they related? [0.03%]
生物材料的地形提示和成纤维细胞活化有关吗？
Zuhan Chen,Huanjing Bi,Xiaoming Ding
Zuhan Chen
The implantation of foreign materials often leads to fibroblast activation and fibrous capsule formation. The process of fibroblast-to-myofibroblast transition (FMT) is partially influenced by the surface properties of biomaterials, includi...
Differentiation potential of periodontal Col1+ cells under orthodontic force [0.03%]
正畸力作用下牙周Col1+细胞的分化潜能研究
Xinyu Wang,Xiangru Huang,Xin Gao et al.
Xinyu Wang et al.
Mechanical force often has clear effects on tissue niche remodeling. However, the changes in stem cells and their roles in clinical treatment remain unclear. Orthodontic tooth movement (OTM), the primary approach to treating dental-maxillof...
Role and potential therapeutic strategies of matrix mechanics for optimizing tumor radiotherapy [0.03%]
基质力学在肿瘤放疗中的作用及潜在治疗策略
Yaxin Deng,Guobao Chen,Jiali Xiao et al.
Yaxin Deng et al.
Radiation therapy is one of the most effective therapeutic modalities for tumors. The changes in matrix stiffness of tumors and associated tissues are important consequences of side effects after radiotherapy. They are documented to induce ...
Substrate topography affects PC12 cell differentiation through mechanotransduction mechanisms [0.03%]
基底拓扑通过机械转导机制影响PC12细胞分化
Lina Papadimitriou,Anna Karagiannaki,Emmanuel Stratakis et al.
Lina Papadimitriou et al.
Neural stem cells in vivo receive information from biochemical and biophysical cues of their microenvironment that affect their survival, proliferation and differentiation toward specific lineages. Recapitulation of these conditions in vitr...