Substrate stiffness modulates phenotype-dependent fibroblast contractility and migration independent of TGF- β stimulation [0.03%]
基质刚度通过调节表型相关的成纤维细胞收缩性和迁移性影响转化生长因子β的刺激独立作用
Mirko D&#x;Urso,Pim van den Bersselaar,Sarah Pragnere et al.
Mirko D&#x;Urso et al.
During wound healing, fibroblasts undergo radical processes that impact their phenotype and behavior. They are activated, recruited to the injury site, assume a contractile phenotype, and secrete extracellular matrix proteins to orchestrate...
Yunlong Huo
Yunlong Huo
Diffuse myocardial fibrosis affects disease severity and outcomes in multiple heart diseases. A recent study in NATURE has shown a chemomechanical method to regulate myocardial stromal cell states to suppress fibrosis in vitro and in vivo, ...
Three-dimensional traction technology and its application in mechanomedicine [0.03%]
三维牵引技术及其在机理医学中的应用
Xinman Chen,Chenyang Ji,Xi Liu et al.
Xinman Chen et al.
Endogenous forces generated by living cells are essential for biological processes and physiological functions of cells and tissues. Over the last several decades, numerous methods for detecting traction forces have been developed. Here we ...
Mechanotransduction in neutrophil: Mechanosensing and immune function regulation [0.03%]
中性粒细胞机械力转导：力学感知与免疫功能调控
Wenying Zhao,Jin Wang,Jing Wang
Wenying Zhao
Immune cells sense and transduce mechanical signals such as stiffness, stretch, compression, and shear stress. In the past few years, our understanding of the mechanosensitive signaling pathways in myeloid cells has significantly expanded, ...
Theta-shaking mitigates cognitive-emotional decline via subiculum and ventral septum metabolic plasticity [0.03%]
θ频段脑电刺激通过海马下托和腹侧隔核的代谢可塑性减轻认知情绪减退
Runhong Yao,Kouji Yamada,Hirohide Sawada et al.
Runhong Yao et al.
Aging-associated cognitive decline remains a major challenge in gerontology; few non-invasive interventions provide both mechanistic insight and translational feasibility. We investigated whether low-frequency "theta-shaking" whole-body vib...
Allosteric pockets in the measles and Nipah virus polymerases: Mechanobiological insights and AI-driven drug discovery opportunities [0.03%]
麻疹病毒和 nipah 病毒聚合酶中的别构位点：机械生物学见解与人工智能驱动的药物发现机会
Yiru Wang,Lixia Zhao,Heqiao Zhang
Yiru Wang
Nonsegmented negative-sense RNA viruses (nsNSVs)-including highly pathogenic pathogens such as measles virus (MeV), Nipah virus (NiV), Hendra virus (HeV), Ebola virus (EBOV), and others-pose major global health threats, yet most lack approv...
Meng Yao,Yao Zong,Junjie Gao
Meng Yao
Mechanical confinement of cells, as occurs during processes like tumor cell invasion or immune cell trafficking, poses a pressure that can threaten nuclear integrity and cell viability. Recent findings illuminate a rapid adaptive mechanism ...
Piezo1 activates nitric oxide synthase in red blood cells via protein kinase C with increased activity in diabetes [0.03%]
糖尿病患者红细胞中PKC激活的NOS通路促进血小板反应性增强
Gurneet S Sangha,Lauren V Smith,Marzyeh Kheradmand et al.
Gurneet S Sangha et al.
Nitric oxide (NO) is a key signaling molecule in maintaining cardiovascular health. While endothelial cells were initially thought to exclusively contain endothelial nitric oxide synthase (eNOS), an enzyme that produces NO, recent evidence ...
Three-dimensional spheroid models for cardiovascular biology and pathology [0.03%]
三维球体模型在心血管生物学和病理学中的应用
Alanna Krug,Gabrielle Inserra,Rhonda Drewes et al.
Alanna Krug et al.
Scaffold-free three-dimensional (3D) cellular spheroid cultures better replicate the in vivo cellular microenvironments of complex tissues than traditional two-dimensional (2D) cell cultures, as they promote more intricate cell-cell and cel...
Causal association analysis between blood metabolomes and osteopenia and therapeutic target prediction for mechanomedicine [0.03%]
骨质疏松症血浆代谢组因果关联分析及机制药物学治疗靶点预测
Ruobing Liu,Yaru Huang,Maogang Jiang et al.
Ruobing Liu et al.
Blood metabolomes have been linked to osteoporosis, yet the precise causal relationship with osteopenia, its preventable early stage, remains unclear. This study aimed to uncover the genetic causality between blood metabolomes and osteopeni...