Electrostatic charge at the biomaterial-pathogen interface influences antibiotic efficacy [0.03%]
生物材料与病原体界面的静电荷影响抗生素疗效
Andrew Hayles,Huu Ngoc Nguyen,Markos Alemie et al.
Andrew Hayles et al.
Implant-associated infections (IAI) are a considerable burden for healthcare systems globally. While novel anti-infective biomaterials are being pursued, prophylactic antibiotic treatment remains the most important intervention for mitigati...
Targeting the parasite's lifeline: knockout of SL transporters confers durable Striga resistance in sorghum [0.03%]
靶向寄生植物的“生命线”：敲除转运蛋白基因使高丹草获得持久的鬼伞抗性
Jiayang Shi,Feifei Yu
Jiayang Shi
Simplifying the protocol for low-pollution-risk, efficient mouse myoblast isolation and differentiation [0.03%]
低污染风险的高效小鼠肌母细胞分离和分化的简化protocol
Yi Luo,Jia-Dong Zhang,Xue-Gang Zhao et al.
Yi Luo et al.
Myoblasts are the primary effector cells that play crucial roles in myogenesis and muscle regeneration following injury. However, isolating purified primary myoblasts from murine skeletal muscle poses challenges for junior researchers. Here...
Molecular mapping of candidate genes in determining red color of perilla leaf [0.03%]
紫苏叶红色决定候选基因的分子标记
Guanwen Xie,Yuxuan Zhang,Shen Xiao et al.
Guanwen Xie et al.
Perilla frutescens is a traditional medicinal plant and functional food in Asian communities, characterized by distinct red and green leaf types that have significant phenotypic and medicinal implications. However, the genetic mechanisms co...
Qian-Hui Zhang,Yi-Qi Chen,Zhen-Bang Li et al.
Qian-Hui Zhang et al.
Soil Cadmium (Cd) contamination is a worldwide problem with negative impacts on human health. Cultivating the Cd-Pollution Safety Cultivar (Cd-PSC) with lower Cd accumulation in edible parts of plants is an environmentally friendly approach...
Thermal proteome profiling unveils protein targets of deoxycholic acid in living neuronal cells [0.03%]
热蛋白组学揭示了去氧胆酸在活神经细胞中的蛋白质靶点
Hemi Luan,Xuan Li,Wenyong Zhang et al.
Hemi Luan et al.
Bile acids, synthesized in the liver and modified by the gut microbiota, play vital roles in various physiological processes. The dysregulation of bile acids has been extensively documented in patients with neurodegenerative diseases. Howev...
Jianhua Yang,Shi Xiao
Jianhua Yang
Saving coral reefs: significance and biotechnological approaches for coral conservation [0.03%]
珊瑚礁的保存：珊瑚保护的意义及生物技术方法
Pansa Cecchini,Thomas Nitta,Edoardo Sena et al.
Pansa Cecchini et al.
Coral reefs are highly productive ecosystems that provide valuable services to coastal communities worldwide. However, both local and global anthropogenic stressors, threaten the coral-algal symbiosis that enables reef formation. This break...
Pathogenesis of influenza and SARS-CoV-2 co-infection at the extremes of age: decipher the ominous tales of immune vulnerability [0.03%]
流感和SARS-CoV-2合并感染在全年龄段中的致病机理：解析免疫脆弱性带来的恐怖故事
Kai-Lin Mai,Wei-Qi Pan,Zheng-Shi Lin et al.
Kai-Lin Mai et al.
The co-circulation of influenza and SARS-CoV-2 has led to co-infection events, primarily affecting children and older adults, who are at higher risk for severe disease. Although co-infection prevalence is relatively low, it is associated wi...
Therapeutic gene correction of HBB frameshift CD41-42 (-TCTT) deletion in human hematopoietic stem cells [0.03%]
人类造血干细胞中HBB框移CD41-42(-TCTT)缺失的治疗性基因矫正
Qianyi Liu,Xinyu Li,Hui Xu et al.
Qianyi Liu et al.
Β-thalassemia is one of the global health burdens. The CD41-42 (-TCTT) mutation at HBB is the most prevalent pathogenic mutation of β-thalassemia in both China and Southeast Asia. Previous studies focused on repairing the HBB CD41-42 (-TC...