The potential of metabolic engineering for sustainable phytosterol production [0.03%]
代谢工程在可持续植物甾醇生产中的潜力
Runmeng Hu,Xueni Di,Guangli Li et al.
Runmeng Hu et al.
Phytosterols, essential components pivotal to plant membrane stability and celebrated for their extensive pharmacological benefits, have garnered considerable attention across industries, including food fortification, nutraceuticals, and ph...
Engineering a robust IsPETase for energy-efficient PET depolymerization in natural seawater at ambient temperatures [0.03%]
一种在自然海水中室温高效降解聚对苯二甲酸乙二醇酯的耐盐酶工程改造及优化
Xin Huang,Qian Jia,Guang Li et al.
Xin Huang et al.
Enzymatic depolymerization of polyethylene terephthalate (PET), the world's most widely used polyester, in seawater at ambient temperature offers a promising and energy-efficient route for freshwater-free plastic recycling. While a number o...
EVmiRED: a curated database of miRNA editing landscape in extracellular vesicles [0.03%]
EVmiRED：一个关于细胞外囊泡中miRNA编辑景观的数据库
KaHei Kou,Lanqi Wen,Luo Yang et al.
KaHei Kou et al.
Metastasis accounts for the vast majority of tumor-related mortality. Certain populations of tumor cells exhibit organotropism by preferentially colonizing specific distant organs. The organ specificity of metastatic cells is determined by ...
Machine learning-driving optimization and spatial assembly of a cell-free system for high-yield liquiritigenin production [0.03%]
基于机器学习驱动的细胞无体系优化及空间组装高效生产甘草素异鼠李素路径前体分子 Liquiritigenin 的研究
Fei Liu,Si-Bo Zhao,Yan-Hua Liu et al.
Fei Liu et al.
Liquiritigenin is a medicinal flavonoid whose production is constrained by inefficient plant extraction and complex chemical synthesis. To overcome this, we developed a modular cell-free multi-enzyme system for its efficient biosynthesis fr...
Structural pharmacology of Chinese medicine: technological breakthroughs in decoding multi-target synergy and precision mechanisms [0.03%]
中药结构药理学：解码多靶标协同和精准机制的技术突破
Caiyan Wang,Yanling Li,Lin Zhuo et al.
Caiyan Wang et al.
Traditional Chinese Medicine (TCM) offers valuable therapeutic strategies for chronic and infectious diseases, yet the inherent complexity of its multi-component, multi-target formulations and synergistic effects presents substantial challe...
Acriflavine-empowered IR780-PTX albumin nanoparticles for reinforced synergistic photochemotherapy [0.03%]
用于增强协同光化疗的acriflavine增强型IR780-PTX白蛋白纳米粒子
Dazhao Li,Tong Wang,Hongchao Liu et al.
Dazhao Li et al.
Traditional chemotherapy and radiotherapy for glioma are challenging due to the hypoxia in tumor microenvironment and the inability of chemotherapeutic agents to enter into tumor cells. Phototherapy is a novel therapeutic approach against v...
Nanopore direct RNA sequencing for RNA modification analysis: workflow assessment and computational tool benchmarking [0.03%]
纳米孔直接RNA测序在RNA修饰分析中的工作流程评估及计算工具基准测试
Zhixing Wu,Jiayi Li,Rong Xia et al.
Zhixing Wu et al.
Recent advancements in sequencing technologies have transformed the characterization of genomic and transcriptomic complexity. In this review, we present a comprehensive overview of Oxford Nanopore Technologies (ONT), emphasizing its unique...
Unlocking the black box: multimodal imaging and quantitative analysis of plant vesicular trafficking [0.03%]
破解“黑箱”：植物囊泡运输的多模态成像与定量分析
Yanyan Zhang,Changwen Xu,Xinxiu Zuo et al.
Yanyan Zhang et al.
How do plants, lacking a central nervous system, translate environmental stimuli into physiological actions within milliseconds? Vesicular trafficking acts as a cellular core signal and material transport hub that facilitates this rapid ada...
The expanding role of m6A RNA modification in plant-virus dynamics: friend, foe, or both? [0.03%]
m６A RNA修饰在植物病毒动力学中的作用日益扩大：朋友、敌人还是两者皆是？
Jia-Hui Liu,Hao Yu,Cheng-Guo Duan
Jia-Hui Liu
N6-methyladenosine (m6A), the most prevalent internal mRNA modification, regulates plant development and stress responses through modulating various mRNA metabolic processes and epigenetic effects. Although well studied in animals, its role...
Detection of plasma EV-associated TRAIL by nanoscale flow cytometry for liver metastasis prediction in PDAC [0.03%]
通过纳米级流式细胞术检测血浆EV相关的TRAIL以预测PDAC肝转移
Chun-Xiang Huang,Jia-Hong Jian,Jun-Sheng Hao et al.
Chun-Xiang Huang et al.
Extracellular vesicles (EVs) mediate tumor-host communication and represent a promising liquid biopsy source for metastasis risk assessment, yet quantitative detection of low-abundance, epitope-defined EV subpopulations in plasma remains te...