Incompletely closed HIV-1CH040 envelope glycoproteins resist broadly neutralizing antibodies while mediating efficient HIV-1 entry [0.03%]
未闭合的HIV-1 CH040包膜糖蛋白能够抵抗广谱中和抗体，但可介导高效的HIV-1感染
Durgadevi Parthasarathy,Stephanie Pickthorn,Shamim Ahmed et al.
Durgadevi Parthasarathy et al.
HIV-1 envelope glycoproteins (Envs) mediate viral entry and are sole target of neutralizing antibodies. Thus, HIV-1 Envs must maintain a delicate balance between evading neutralizing antibodies while still preserving viral compatibility to ...
Dose and strain dependent lethality of Usutu virus in an Ifnar-/- mouse model [0.03%]
干扰素信号缺陷小鼠模型中Usutu病毒毒株和剂量依赖性致死率研究
Johanna M Duyvestyn,Eleanor M Marshall,Peter J Bredenbeek et al.
Johanna M Duyvestyn et al.
Usutu virus (USUV) is a mosquito-borne zoonotic flavivirus with a geographic range that has expanded over recent years. Maintained in a transmission cycle between mosquito vectors and avian reservoirs the virus can cause large seasonal outb...
Expansion of the genomic and functional diversity of global ocean giant viruses [0.03%]
全球海洋巨病毒基因组和功能多样性研究取得进展
Benjamin Minch,Mohammad Moniruzzaman
Benjamin Minch
Giant viruses (GVs) play crucial roles in the global ocean microbial food web and biogeochemistry. Recent metagenomic advances have uncovered >1800 new GV genomes from the world's oceans. While this rapid increase in genomic information is ...
Atomic force microscopy at the forefront: unveiling foodborne viruses with biophysical tools [0.03%]
原子力显微镜在前沿：利用生物物理工具揭示食源性病毒
Rita Dos Santos Natividade,Barbara Danzer,Veronika Somoza et al.
Rita Dos Santos Natividade et al.
Foodborne viruses are significant public health threats, capable of causing life-threatening infections and posing major risks for future pandemics. However, the development of vaccines and treatments remains limited due to gaps in understa...
Pathogenesis and transmission of SARS-CoV-2 D614G, Alpha, Gamma, Delta, and Omicron variants in golden hamsters [0.03%]
SARS-CoV-2 D614G、Alpha、Gamma、Delta和Omicron变异株在金黄仓鼠中的致病性和传播性研究
Andra Banete,Bryan D Griffin,Juan C Corredor et al.
Andra Banete et al.
Since the emergence of SARS-CoV-2 in humans, novel variants have evolved to become dominant circulating lineages. These include D614G (B.1 lineage), Alpha (B.1.1.7), Gamma (P.1), Delta (B.1.617.2), and Omicron BA.1 (B.1.1.529) and BA.2 (B.1...
Zika virus M protein latches and locks the E protein from transitioning to an immature state after prM cleavage [0.03%]
寨卡病毒M蛋白在prM切割后锁定E蛋白向未成熟状态转变的功能
Sydney A Majowicz,Anoop Narayanan,Ibrahim M Moustafa et al.
Sydney A Majowicz et al.
During flavivirus maturation, the structural proteins prM (pre-membrane) and E (envelope) undergo extensive low pH-mediated conformational changes, transitioning from spiky trimeric to smooth dimeric prM/E heterodimers which allow for furin...
An XBB.1.5-based inactivated SARS-CoV-2 vaccine partially protects against XBB.1.5 and JN.1 strains in hamsters [0.03%]
基于XBB.1.5的灭活新型冠状病毒疫苗可部分预防雪貂XBB.1.5和JN.1毒株感染
Ryuta Uraki,Mutsumi Ito,Maki Kiso et al.
Ryuta Uraki et al.
The SARS-CoV-2 Omicron BA.2.86 variant and its descendant lineages, including JN.1, are rapidly spreading and becoming dominant globally. Vaccination is an essential primary preventative measure. While mRNA vaccines have been widely used wo...
Respiratory syncytial virus glycoprotein G impedes CX3CR1-activation by CX3CL1 and monocyte function [0.03%]
呼吸道合胞病毒糖蛋白G通过CX3CL1抑制CX3CR1的活化及单核细胞的功能
Robert Meineke,Ayse Agac,Marie-Christin Knittler et al.
Robert Meineke et al.
The soluble form of the Respiratory Syncytial Virus (RSV) G protein (sG) bears resemblance to the chemokine fractalkine (CX₃CL1). Both RSV sG and CX3CL1 possess a mucin-like domain and a CX3C motif, exist in membrane-associated and soluble...
A plant virus differentially alters DNA methylation in two cryptic species of a hemipteran vector [0.03%]
一种植物病毒通过差异调控双隐秘半翅目媒介物种的DNA甲基化来改变自身基因表达模式
Michael A Catto,Saptarshi Ghosh,Sudeep Pandey et al.
Michael A Catto et al.
Epigenetic patterns including DNA methylation are known to vary between distantly related species, but it is not clear how these patterns differ at an intraspecific level. The sweetpotato whitefly, Bemisia tabaci (Gennadius) (Aleyrodidae; H...
Mohammad Enamul Hoque Kayesh,Michinori Kohara,Kyoko Tsukiyama-Kohara
Mohammad Enamul Hoque Kayesh
Viral infections can trigger increased reactive oxygen species (ROS) production and a reduced antioxidant response in the host, leading to redox stress, inflammation, apoptosis, and ultimately, cell and tissue damage, which contribute to di...