Visualising viral interactions and mechanisms at the nanoscale with expansion microscopy [0.03%]
利用膨胀显微镜在纳米尺度上可视化病毒相互作用及工作机制
Lisa Övermöhle,Maximilian Baum,Rohan Bhatia et al.
Lisa Övermöhle et al.
Expansion microscopy is a groundbreaking technique that enables nanoscale imaging of biological specimens using standard optical microscopes. By embedding specimens in swellable hydrogels, it achieves sub-diffraction resolution. Compatible ...
Discovery of potent cross-neutralizing antibodies against Marburg and Ravn viruses with therapeutic potential [0.03%]
具有治疗潜力的马堡病毒和拉文病毒强效交叉中和抗体的发现
Takeshi Saito,Hiroko Miyamoto,Manabu Igarashi et al.
Takeshi Saito et al.
Marburg virus (MARV) and Ravn virus (RAVV) are highly pathogenic filoviruses that cause Marburg virus disease (MVD), for which no approved treatment currently exists. In this study, we describe a panel of 10 novel mouse-derived monoclonal a...
VHH antibody loop guides design of a synthetic macrocyclic peptide that potently blocks influenza virus membrane fusion [0.03%]
VHH抗体可变环引导设计合成的大环肽以有效阻断流感病毒膜融合
Rameshwar U Kadam,Jarek Juraszek,Boerries Brandenburg et al.
Rameshwar U Kadam et al.
Miniaturizing biologically complex structural motifs to produce synthetic functional mimetics holds significant promise for development of new therapeutic modalities. Here, we demonstrate a unique approach using the key binding loop of the ...
Antagonistic activity against innate immunity determines virulence in mammalian bornaviruses [0.03%]
针对哺乳动物博纳病毒的固有免疫拮抗活性决定其毒力
Akiko Makino,Chiaki Tanaka,Kan Fujino et al.
Akiko Makino et al.
Variegated squirrel bornavirus 1 (VSBV-1) is a lethal emerging disease that has been discovered in privately owned and zoo squirrels, but its pathogenicity as a zoonotic pathogen remains uncertain. To better understand VSBV-1 virulence, we ...
Characterization of a synthetic infectious cloned DNA of simian foamy virus serotype 1 [0.03%]
一种合成的痘病毒1型感染性克隆DNA的表征
Sandra M Fuentes,Nicholas Mattson,Trent J Bosma et al.
Sandra M Fuentes et al.
A virus stock of a cloned infectious DNA of simian foamy virus serotype 1 (SFV-1) was obtained in M. dunni cells (designated as pSFV-MD). The kinetics of replication were similar to the parent uncloned SFV-MD stock in M. dunni cells and in ...
Fucose dependent rotavirus and norovirus require fucosidase activity for optimal replication [0.03%]
半乳糖胺和岩藻糖对于轮状病毒和诺如病毒的复制是必需的
Nazaret Peña-Gil,Nanci Santos-Ferreira,Sonia Llanos-Villatoro et al.
Nazaret Peña-Gil et al.
Rotavirus (RV) and norovirus (NoV) are enteric viruses responsible for acute gastroenteritis that require fucosylated histo-blood group antigens for infection in humans. How the interaction of these viruses with fucosylated glycans modulate...
Sequelae of viral CNS infections including outcomes, mechanisms, and knowledge gaps [0.03%]
病毒感染性中枢神经系统疾病的后遗症及其结局、机制和认识盲区
Rachel Kelly,Line S Reinert,Søren R Paludan
Rachel Kelly
Neurotropic viruses affecting the central nervous system cause significant short- and long-term morbidity and mortality. Sequelae are extremely prevalent, with up to 50% of survivors experiencing neurological, neuropsychiatric, and behavior...
Vector surveillance during a major chikungunya outbreak in northwestern São Paulo state, Brazil [0.03%]
巴西圣保罗西北部一次大规模登革热暴发期间的媒介监测活动
Cecília Artico Banho,Maisa Carla Pereira Parra,Olivia Borghi Nascimento et al.
Cecília Artico Banho et al.
Brazil constitutes a hotspot for arbovirus emergence, posing persistent public health challenges. In São José do Rio Preto (SJdRP), dengue has historically predominated, whereas only 62 chikungunya virus (CHIKV) cases were reported betwee...
Viral helicase and methyltransferase promote genotype one-hepatitis e virus internal ribosome entry site-like element activity [0.03%]
病毒解旋酶和甲基转移酶可促进基因1型戊型肝炎病毒内部核糖体进入位点相关元件的活性
Shiv Kumar,Samriddhi Mehta,Jyoti Gupta et al.
Shiv Kumar et al.
Hepatitis E virus (HEV) is a leading cause of acute viral hepatitis. Our earlier study reported the presence of an 87-nucleotide-long internal ribosome entry-site-like element (IRESl) in the genotype 1 (g1)-HEV genome, which mediated cap-in...
Estimating the decay of protective antibodies induced by SARS-CoV-2 mRNA vaccination and hybrid immunity [0.03%]
估计由SARS-CoV-2信使核糖核酸疫苗诱导的保护性抗体消退情况及评估混合免疫状况
McKenna D Roe,Si&#x;Ana A Coggins,Emily S Darcey et al.
McKenna D Roe et al.
Starting in 2020, we quantified anti-wildtype SARS-CoV-2 spike sera IgG at monthly intervals from generally healthy adults after various doses of mRNA-based COVID-19 vaccination and in the context of hybrid immunity. Confirmed post-vaccinat...