Martha M Luka,James R Otieno,Everlyn Kamau et al.
Martha M Luka et al.
Rhinoviruses (RV), common human respiratory viruses, exhibit significant antigenic diversity, yet their dynamics across distinct social structures remain poorly understood. Our study delves into RV dynamics within Kenya by analysing VP4/2 s...
An HIV-1 broadly neutralizing antibody overcomes structural and dynamic variation through highly focused epitope targeting [0.03%]
一种HIV-1广谱中和抗体通过高度集中的靶点克服结构和动态变化
Edgar A Hodge,Ananya Chatterjee,Chengbo Chen et al.
Edgar A Hodge et al.
The existence of broadly cross-reactive antibodies that can neutralize diverse HIV-1 isolates (bnAbs) has been appreciated for more than a decade. Many high-resolution structures of bnAbs, typically with one or two well-characterized HIV-1 ...
Rosie M Mundy,Alexander T Baker,Emily A Bates et al.
Rosie M Mundy et al.
Human adenoviruses (HAdV) are widespread pathogens causing usually mild infections. The Species D (HAdV-D) cause gastrointestinal tract infections and epidemic keratoconjunctivitis (EKC). Despite being significant pathogens, knowledge aroun...
Rural populations facilitated early SARS-CoV-2 evolution and transmission in Missouri, USA [0.03%]
农村人口促进了美国密苏里州早期SARS-CoV-2的进化和传播
Cynthia Y Tang,Tao Li,Tricia A Haynes et al.
Cynthia Y Tang et al.
In the United States, rural populations comprise 60 million individuals and suffered from high COVID-19 disease burdens. Despite this, surveillance efforts are biased toward urban centers. Consequently, how rurally circulating SARS-CoV-2 vi...
Novel mechanism of the COVID-19 associated coagulopathy (CAC) and vascular thromboembolism [0.03%]
新冠肺炎相关凝血异常和血管性血栓栓塞的新机制
Mahavir Singh,Sathnur Pushpakumar,Yuting Zheng et al.
Mahavir Singh et al.
Previous studies from our laboratory revealed that SARS-CoV-2 spike protein (SP) administration to a genetically engineered model expressing the human angiotensin-converting enzyme 2; ACE2 receptor (i.e., hACE2 humanized mouse) mimicked the...
Synthetic recovery of Yada Yada virus expands insect-specific alphavirus knowledge and facilitates production of chimeric viruses [0.03%]
人工合成雅达病毒扩展了昆虫特异性甲病毒的知识并促进了嵌合病毒的产生
Few insect-specific alphaviruses (ISA) have been discovered, with even fewer culturable to facilitate full characterisation. Here, we report the recovery of an infectious clone of Yada Yada virus (YYV)-a virus previously only detected by me...
Conserved role of spike S2 domain N-glycosylation across betacoronaviruses [0.03%]
刺突S2结构域N-糖基化在贝塔冠状病毒中的保守作用
Besides acting as an immunological shield, the N-glycans of SARS-CoV-2 are also critical for viral life cycle. As the S2 subunit of spike is highly conserved across betacoronaviruses, we determined the functional significance of the five 's...
Syrian hamsters (Mesocricetus auratus) as an upper respiratory tract model for respiratory syncytial virus infection [0.03%]
用于呼吸合胞病毒感寿的拟地鼠上呼吸道模型
Respiratory syncytial virus (RSV) is one of the leading causes of respiratory tract infection in children, immunocompromised individuals and older adults. Vaccines have recently been approved for use in adults and although further efforts t...
Dominant HPAIV H5N1 genotypes of Germany 2021/2022 are linked to high virulence in Pekin ducklings [0.03%]
德国2021/2022年流行的高致病性H5N1主要基因型与北京鸭中的高毒力有关
Highly pathogenic avian influenza viruses (HPAIV) of H5 clade 2.3.4.4b pose an ongoing threat worldwide. It remains unclear whether this panzootic situation would favor low virulent phenotypes expected by the 'avirulence hypothesis' of vira...
Vaccination with ancestral SARS-CoV-2 spike adjuvanted with TLR agonists provides cross-protection against XBB.1 [0.03%]
用TLR激动剂作为佐剂的新型冠状病毒祖先毒株S蛋白疫苗能够对XBB.1提供交叉保护作用
Many different platforms have been used to develop highly protective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans. However, protection has eroded over time due to the emergence of antigenically div...