A novel papillomavirus in a New Zealand fur seal (Arctocephalus forsteri) with oral lesions [0.03%]
一种新的乳头状瘤病毒及其在新西兰皮草海狮（阿德利氏海狮）口腔病变中的作用
Jonathon C O Mifsud,Jane Hall,Kate Van Brussel et al.
Jonathon C O Mifsud et al.
Despite being the predominant seal species in the Australian-New Zealand region and serving as a key indicator of marine environmental health, little is known about infectious diseases in New Zealand fur seals (Long-nosed fur seal; Arctocep...
Structural basis of Zika virus NS1 multimerization and human antibody recognition [0.03%]
寨卡病毒NS1多聚化及与人源抗体识别的结构基础
Bing Liang Alvin Chew,An Qi Ngoh,Wint Wint Phoo et al.
Bing Liang Alvin Chew et al.
Zika virus (ZIKV) belongs to the Flavivirus genus of the Flaviviridae family along with the four serotypes of dengue virus (DENV1-4). The recent global outbreaks of contemporary ZIKV strains demonstrated that infection can lead to neurologi...
Survey of white-footed mice (Peromyscus leucopus) in Connecticut, USA reveals low SARS-CoV-2 seroprevalence and infection with divergent betacoronaviruses [0.03%]
美国康涅狄格州白足鼠（Peromyscus leucopus）调查显示SARS-CoV-2血清阳性率较低且感染有分歧的β冠状病毒
Rebecca Earnest,Anne M Hahn,Nicole M Feriancek et al.
Rebecca Earnest et al.
Diverse mammalian species display susceptibility to SARS-CoV-2. Potential SARS-CoV-2 spillback into rodents is understudied despite their host role for numerous zoonoses and human proximity. We assessed exposure and infection among white-fo...
Modulating cytokine microenvironment during T cell activation induces protective RSV-specific lung resident memory T cells in early life in mice [0.03%]
调节T细胞活化期间的小鼠早期生命的细胞因子微环境可诱导保护性的呼吸道合胞病毒特异性肺驻留记忆T细胞
Ziyin Wang,Miko Zhong,Chubicka Thomas et al.
Ziyin Wang et al.
Maternal immunisation against respiratory viruses provides protection in early life, but as antibodies wane, there can be a gap in coverage. This immunity gap might be filled by inducing pathogen-specific lung tissue-resident T cells (TRM)....
Optimal thresholds and key parameters for predicting influenza A virus transmission events in ferrets [0.03%]
预测猪体内流感A病毒传播事件的最佳阈值和关键参数
Troy J Kieran,Xiangjie Sun,Taronna R Maines et al.
Troy J Kieran et al.
Although assessments of influenza A virus transmissibility in the ferret model play a critical role in pandemic risk evaluations, few studies have investigated which virological data collected from virus-inoculated animals are most predicti...
Potent neutralization by a RBD antibody with broad specificity for SARS-CoV-2 JN.1 and other variants [0.03%]
一种广谱靶向SARS-CoV-2(JN.1等变异株)的RBD抗体具有强力中和作用
Michael S Piepenbrink,Ahmed Magdy Khalil,Ana Chang et al.
Michael S Piepenbrink et al.
SARS-CoV-2 continues to be a public health burden, driven in-part by its continued antigenic diversification and resulting emergence of new variants. By increasing herd immunity, current vaccines have improved infection outcomes for many. H...
Characterization of a SARS-CoV-2 Omicron BA.5 direct-contact transmission model in hamsters [0.03%]
描述雪貂中的SARS-CoV-2奥密克戎BA.5毒株直接接触传播模型的特征
Kim Handrejk,Katharina S Schmitz,Edwin J B Veldhuis Kroeze et al.
Kim Handrejk et al.
As SARS-CoV-2 continues to evolve antigenically to escape vaccine- or infection-induced immunity, suitable animal models are needed to study novel interventions against viral variants. Syrian hamsters are often used because of their high su...
Julie Thomy,Christopher R Schvarcz,Kelsey A McBeain et al.
Julie Thomy et al.
Viruses in the phylum Nucleocytoviricota are large, complex and have an exceptionally diverse metabolic repertoire. Some encode hundreds of products involved in the translation of mRNA into protein, but none was known to encode any of the p...
Flaviviruses manipulate mitochondrial processes to evade the innate immune response [0.03%]
黄病毒操纵线粒体过程以躲避固有免疫反应
RuthMabel Boytz,Kadiatou Keita,Joanna B Pawlak et al.
RuthMabel Boytz et al.
Mitochondria are essential eukaryotic organelles that regulate a range of cellular processes, from metabolism to calcium homeostasis and programmed cell death. They serve as essential platforms for antiviral signaling proteins during the in...
Study of key residues in MERS-CoV and SARS-CoV-2 main proteases for resistance against clinically applied inhibitors nirmatrelvir and ensitrelvir [0.03%]
研究MERS-CoV和SARS-CoV-2主要蛋白酶中关键残基对临床应用抑制剂奈马特韦和恩斯维特的抗性问题
Laura Krismer,Helge Schöppe,Stefanie Rauch et al.
Laura Krismer et al.
The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an epidemic, zoonotically emerging pathogen initially reported in Saudi Arabia in 2012. MERS-CoV has the potential to mutate or recombine with other coronaviruses, thus acquirin...