Augmentation of Omicron BA.1 pathogenicity in hamsters using intratracheal inoculation [0.03%]
通过气管内接种增强奥密克戎BA.1在仓鼠中的致病性
Julia R Port,Claude Kwe Yinda,Claire Ruckel et al.
Julia R Port et al.
The Omicron BA.1 variant of SARS-CoV-2 displays an attenuated phenotype in the Syrian hamster after intranasal inoculation. This is characterized by reduced viral replication and lung pathology in the lower respiratory tract. Here, we repor...
Uncovered diversity of infectious circular RNAs: A new paradigm for the minimal parasites? [0.03%]
可感染的环状RNA的多样性及其作为最小寄生体的新概念
Joan Marquez-Molins
Joan Marquez-Molins
Infectious circular RNAs (circRNAs) have been considered as biological oddities only occurring in plants, with limited exceptions. However, a great diversity of viroid-like circRNAs has been recently uncovered by the high-throughput explora...
Automated classification of giant virus genomes using a random forest model built on trademark protein families [0.03%]
基于商标蛋白家族的随机森林模型的巨病毒基因组自动化分类
Anh D Ha,Frank O Aylward
Anh D Ha
Viruses of the phylum Nucleocytoviricota, often referred to as "giant viruses," are prevalent in various environments around the globe and play significant roles in shaping eukaryotic diversity and activities in global ecosystems. Given the...
Identification of amino acids restricting HBV receptor function in porcine NTCP [0.03%]
鉴定影响猪NTCPHBV受体功能的氨基酸位点
Samuel D Jeske,Jochen M Wettengel,Florian Gegenfurtner et al.
Samuel D Jeske et al.
With 254 million chronically infected patients, hepatitis B virus (HBV) continues to be a severe health threat. While animal models play a crucial role in developing new therapies, the availability of preclinical HBV models is very limited....
Characterisation of a Japanese Encephalitis virus genotype 4 isolate from the 2022 Australian outbreak [0.03%]
2022年澳大利亚脑炎病毒疫情中分离的日本脑炎病毒4型毒株的表征
Wilson Nguyen,Narayan Gyawali,Romal Stewart et al.
Wilson Nguyen et al.
Human infections with the Japanese encephalitis virus (JEV) are a leading cause of viral encephalitis. An unprecedented outbreak of JEV genotype 4 was recently reported in Australia, with an isolate (JEVNSW/22) obtained from a stillborn pig...
Evolution at Spike protein position 519 in SARS-CoV-2 facilitated adaptation to humans [0.03%]
SARS-CoV-2刺突蛋白位点519的演化使其更易适应人类
C Cereghino,K Michalak,S DiGiuseppe et al.
C Cereghino et al.
As the COVID-19 pandemic enters its fourth year, the pursuit of identifying a progenitor virus to SARS-CoV-2 and understanding the mechanism of its emergence persists, albeit against the backdrop of intensified efforts to monitor the ongoin...
SARS-CoV-2 infection results in a unique lung proteome long after virus resolution in the hamster [0.03%]
叙利亚金仓鼠感染新型冠状病毒后肺蛋白组长期变化特征
Amrit S Boese,Bryce M Warner,Peter McQueen et al.
Amrit S Boese et al.
Long COVID or post-acute sequelae of COVID-19 (PASC) remains an ongoing public health issue that causes impairment for those afflicted and diminishes their ability to contribute to society. To address the host response underpinning respirat...
Evolutionary trajectory of SARS-CoV-2 genome shifts during widespread vaccination and emergence of Omicron variant [0.03%]
新型冠状病毒疫苗广泛接种背景下基因组变化的进化轨迹及其突变株奥密克戎的出现
Kaitlyn Gayvert,Sheldon McKay,Wei Keat Lim et al.
Kaitlyn Gayvert et al.
Understanding the adaptation of SARS-CoV-2 is critical for the development of effective treatments against this exceptionally successful human pathogen. To predict the emergence of new variants that may escape host immunity or increase viru...
Co-localization of influenza A virus and voltage-dependent calcium channels provides new perspectives on the internalization process in pigs [0.03%]
A型流感病毒和电压依赖性钙通道的共定位为猪的内吞作用提供了新的视角
Charlotte Kristensen,Henrik E Jensen,Ramona Trebbien et al.
Charlotte Kristensen et al.
Influenza A virus (IAV) is an RNA virus that causes respiratory disease in a wide range of mammals including humans and pigs. Cav1.2 is a specific voltage-dependent calcium channel (VDCC) important for the internalization of IAV and VDCC in...
Cracking the code: ET-1 signaling unlocks new therapies for virus-induced osteoarthritis [0.03%]
破解密码：ET-1信号传导解锁病毒诱导性骨关节炎的新疗法
Wern Hann Ng,Patrick Chun Hean Tang,Suresh Mahalingam
Wern Hann Ng
Rheumatic symptoms such as joint inflammation and pain are known features of SARS-CoV-2 infection, though the mechanisms remain unclear. Au and colleagues identified the interaction between the viral spike protein and the endothelin-1 (ET-1...