Toll-like receptor response to Zika virus infection: progress toward infection control [0.03%]
宿主 toll 样受体对寨卡病毒感染的反应：迈向感染控制的新进展
Mohammad Enamul Hoque Kayesh,Michinori Kohara,Kyoko Tsukiyama-Kohara
Mohammad Enamul Hoque Kayesh
Infection with the Zika virus (ZIKV) poses a threat to human health. An improved understanding of the host Toll-like receptor response, disease onset, and viral clearance in vivo and in vitro may lead to the development of therapeutic or pr...
The Wnt/β-catenin pathway is important for replication of SARS-CoV-2 and other pathogenic RNA viruses [0.03%]
Wnt/β-catenin信号通路对SARS-CoV-2及其他致病性RNA病毒复制至关重要
Zaikun Xu,Mohamed Elaish,Cheung Pang Wong et al.
Zaikun Xu et al.
Understanding how viruses affect cellular pathways during infection may facilitate development of host cell-targeted therapeutics with broad-spectrum antiviral activity. The interferon (IFN) response is critical for reducing replication and...
Singapore COVID-19 data cross-validation by the Gaidai reliability method [0.03%]
基于盖达伊可靠性的新加坡新冠肺炎数据交叉检验
Oleg Gaidai,Vladimir Yakimov,Jiayao Sun et al.
Oleg Gaidai et al.
Novel coronavirus infection (COVID-19) has exserted certain burden on global public health, spreading around the world with reportedly low mortality and morbidity. This study advocates novel bio and health system reliability approach, espec...
Brain tropism acquisition: the spatial dynamics and evolution of a measles virus collective infectious unit that drove lethal subacute sclerosing panencephalitis [0.03%]
大脑嗜性获取：引起亚急性硬化性全脑炎的麻疹病毒集体感染单元的空间动力学和进化
Aicha Hanna
Aicha Hanna
Acute viral infections are typically cleared by the host’s immune system, but certain RNA viruses can establish ‘within host’ persistent infections, for example in the central nervous system (CNS). Neurons within the CNS are a potential ...
Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney transplant recipients [0.03%]
揭示IL-2和IL-5在肾移植受者SARS-CoV-2特异性T细胞反应中的作用
Yvette den Hartog,S Reshwan K Malahe,Wim J R Rietdijk et al.
Yvette den Hartog et al.
Kidney transplant recipients (KTRs) are at an increased risk of severe COVID-19 due to compromised immune responses. Although vaccination is critical in preventing severe disease, KTRs have attenuated vaccination-induced immune responses du...
Recruitment of apolipoprotein E facilitates Herpes simplex virus 1 attachment and release [0.03%]
招募载脂蛋白E可促进单纯疱疹病毒1型吸附和释放
Lifeng Liu,Fouzia Bano,Dario Valter Conca et al.
Lifeng Liu et al.
Human apolipoprotein E (ApoE) has been shown to play important roles during primary infection and pathogenesis of several viruses. Furthermore, epidemiological studies suggest that interactions between ApoE 4 and herpes simplex virus type-1...
Pathogenesis of aquatic bird bornavirus 1 in turkeys of different age [0.03%]
不同日龄火鸡感染水域鸟类博尔纳病毒1型的病理变化
Lisa Gordon,Alexander Leacy,Phuc H Pham et al.
Lisa Gordon et al.
Aquatic bird bornavirus 1 (ABBV1), an orthobornavirus in the family Bornaviridae, displays a broad host range among avian species, including poultry. The pathogenesis of orthobornaviruses, at least in mammals and psittacines, appears to be ...
CD8+ T cells promote ZIKV clearance and mitigate testicular damage in mice [0.03%]
CD8+t细胞促进小鼠清除寨卡病毒并减轻对睾丸的损伤
Rafael K Campos,Yuejin Liang,Sasha R Azar et al.
Rafael K Campos et al.
Zika virus (ZIKV) causes human testicular inflammation and alterations in sperm parameters and causes testicular damage in mouse models. The involvement of individual immune cells in testicular damage is not fully understood. We detected vi...
Discordant phylodynamic and spatiotemporal transmission patterns driving the long-term persistence and evolution of human coronaviruses [0.03%]
分歧的系谱动力学和时空传播模式驱动人类冠状病毒的长期存在和进化
Marcus G Mah,Michael A Zeller,Rong Zhang et al.
Marcus G Mah et al.
Four distinct species of human coronaviruses (HCoVs) circulate in humans. Despite the recent attention due to SARS-CoV-2, a comprehensive understanding of the molecular epidemiology and genomic evolution of HCoVs remains unclear. Here, we e...
NEIL1 block IFN-β production and enhance vRNP function to facilitate influenza A virus proliferation [0.03%]
NEIL1通过抑制I型干扰素产生和促进病毒基因组RNA聚合酶复合物的功能来促进甲型流感病毒的复制
Huixia Zhang,Changyan Li,Ruiqi Sun et al.
Huixia Zhang et al.
Influenza A virus (IAV) has developed multiple tactics to hinder the innate immune response including the epigenetic regulation during IAV infection, but the novel epigenetic factors and their mechanism in innate immunity remain well studie...