Coinfection with chikungunya and Zika results in mild disease and distinct inflammatory response [0.03%]
丘凯宁热和寨卡病毒重叠感染会导致较轻病症及不同的炎症反应
Juliana Cardoso Alves,Lucas Sousa Magalhães,Priscila Lima Dos Santos et al.
Juliana Cardoso Alves et al.
Chikungunya (CHIKV) and Zika (ZIKV) viruses, both mosquito-borne, often circulate simultaneously, raising concerns about the effects of coinfection. This study evaluated cytokines, chemokines, and growth factors in 12 patients with concurre...
Conservative taxonomy and quality assessment of giant virus genomes with GVClass [0.03%]
保守的大病毒基因组分类及其质量评估方法GVClass
Thomas M Pitot,Tomáš Brůna,Frederik Schulz
Thomas M Pitot
Large double-stranded DNA viruses of the phylum Nucleocytoviricota (Giant Viruses; GVs) are the largest known viruses, infecting various eukaryotic hosts, particularly protists and algae. These viruses impact biogeochemical cycles and host ...
Senecavirus cetus a novel picornavirus isolated from cetaceans represents a major host switching to the marine environment [0.03%]
来自鲸豚类动物的一种新型小RNA病毒Senecavirus cetus代表了向海洋环境的重要宿主转变
Oksana Vernygora,Daniel Sullivan,Ole Nielsen et al.
Oksana Vernygora et al.
Senecavirus A (SVA), an emerging virus that causes vesicular disease in swine, was, until recently, the only member of the Senecavirus genus (Picornaviridae). Here, we report the isolation and complete genome sequence of two isolates of cet...
Aspects of the lifestyle of multipartite viruses apply to monopartite segmented and perhaps nonsegmented viruses [0.03%]
multipartite病毒的生活习性也适用于单一节段病毒和非节段病毒
Yannis Michalakis,Stéphane Blanc
Yannis Michalakis
Recent research on faba bean necrotic stunt virus, aiming to understand how multipartite viruses function and potentially their existence, revealed three surprising features: a non-uniform segment frequency distribution (genome formula), a ...
Sensitivity of rodents to SARS-CoV-2: Gerbils are susceptible to SARS-CoV-2, but guinea pigs are not [0.03%]
天竺鼠及沙鼠对新冠病毒易感性研究
Kiyoko Iwatsuki-Horimoto,Maki Kiso,Mutsumi Ito et al.
Kiyoko Iwatsuki-Horimoto et al.
Syrian hamster are sensitive to SARS-CoV-2 and widely used as an animal model of COVID-19. In contrast, mice are not readily infected by the ancestral strains of SARS-CoV-2 because of differences in their angiotensin-converting enzyme 2 (AC...
A single amino acid mutation alters multiple neutralization epitopes in the respiratory syncytial virus fusion glycoprotein [0.03%]
呼吸道合胞病毒融合糖蛋白中一个氨基酸的突变即可改变多个表位
Ahmed K Oraby,Aleksandra Stojic,Farah Elawar et al.
Ahmed K Oraby et al.
Respiratory syncytial virus (RSV) is the leading cause of infant hospitalization. All current RSV therapeutics, including antibody prophylaxis and adult vaccination, target the RSV fusion glycoprotein (RSV-F). The seven neutralization sites...
Characterizing changes in transcriptome and kinome responses in testicular cells during infection by Ebola virus [0.03%]
恩巴萨病毒感染期间睾丸细胞转录组和激酶组反应的变化特征
Andrew L Webb,Brayden G Schindell,Geoff Soule et al.
Andrew L Webb et al.
Ebola virus (EBOV) is able to persist and actively replicate in the reproductive tract of male disease survivors months or years after recovery from Ebola virus disease (EVD)1. Persistent EBOV infections are usually asymptomatic and can be ...
Reverse zoonosis of the 2022-2023 human seasonal H3N2 detected in swine [0.03%]
2022-2023年人类季节性H3N2病毒反向人畜共患病感染猪事件
Michael A Zeller,Daniel Carnevale de Almeida Moraes,Giovana Ciacci Zanella et al.
Michael A Zeller et al.
The Iowa State University Veterinary Diagnostic Laboratory detected nineteen human-to-swine reverse zoonoses of the 2022-2023 human seasonal H3N2 between November 2022 and November 2023. Cases from seven U.S. locations were detected: 3 Colo...
Usutu virus and West Nile virus use a transcellular route of neuroinvasion across an in vitro model of the human blood-brain barrier [0.03%]
乌斯土病毒和西尼罗河病毒使用跨细胞途径通过人体血脑屏障体外模型进行神经侵袭
Eleanor M Marshall,Marion Koopmans,Barry Rockx
Eleanor M Marshall
West Nile virus (WNV) leads to thousands of cases of severe neurological disease in humans each year. Usutu virus (USUV) is closely related to WNV, but rarely induces disease in humans. We hypothesised that USUV is less able to cross the bl...
Venezuelan equine encephalitis virus non-structural protein 3 dictates superinfection exclusion in mammalian cells [0.03%]
委内瑞拉马脑炎病毒非结构蛋白3制约哺乳动物细胞超感染排除现象
Tessy A H Hick,Taja Zotler,Davita Bosveld et al.
Tessy A H Hick et al.
Superinfection exclusion (SIE) prevents secondary infections of already infected cells. Arthritogenic alphaviruses induce SIE via early proteolytical cleavage of replicase precursor by non-structural protein 2 (nsP2). Here, we explore the S...