Structural dynamics of the dengue virus non-structural 5 (NS5) interactions with promoter stem-loop A (SLA) [0.03%]
登革病毒非结构蛋白5(NS5)与启动子茎环A(SLA)相互作用的结构动力学
Juliet O Obi,Kyle C Kihn,Linfah McQueen et al.
Juliet O Obi et al.
The dengue virus (DENV) NS5 protein, essential for viral RNA synthesis, is an attractive antiviral drug target. DENV NS5 interacts with the stem-loop A (SLA) promoter at the 5'-untranslated region of the viral genome to initiate negative-st...
Tressy Bosmon,Chantal Abergel,Jean-Michel Claverie
Tressy Bosmon
Some twenty years ago, the discovery of the first giant virus, Acanthamoeba polyphaga mimivirus (now mimivirus bradfordmassiliense species), paved the way for the discovery of more than 10 new families of protist-infecting DNA viruses with ...
Balancing stability and function: impact of the surface charge of SARS-CoV-2 Omicron spike protein [0.03%]
稳定性与功能的平衡：SARS-CoV-2奥密克戎刺突蛋白表面电荷的影响
Daniel Lauster,Rainer Haag,Matthias Ballauff et al.
Daniel Lauster et al.
The ectodomain of the Omicron SARS-CoV-2 spike has an increased positive surface charge, favoring binding to the host cell surface, but may affect the stability of the ectodomain. Thermal stability studies identified two transitions associa...
Atlesh Sudhakar,Donald Wilson,Rachel Devi et al.
Atlesh Sudhakar et al.
Very little is known about the HIV-1 epidemic in Fiji, nor the wider South Pacific region more generally, yet new reported HIV-1 infections are on the rise. As of 2023, there are an estimated 2000 cases of HIV-1 in Fiji with heterosexual co...
Duane J Gubler,Kathryn A Hanley,Thomas P Monath et al.
Duane J Gubler et al.
In 1923, H.R. Carter published a seminal treatise on the possibility of yellow fever virus spreading to the Asia Pacific region, where large numbers of susceptible people were at risk of infection. This paper marks the 100th anniversary of ...
Middle East respiratory syndrome coronavirus (MERS-CoV) internalization does not rely on DPP4 cytoplasmic tail signaling [0.03%]
中东呼吸综合征冠状病毒(MERS-CoV)的摄取不依赖DPP4胞质尾部信号转导
Karthika Thankamani,Divakar Shubham,Gayatri Kandpal et al.
Karthika Thankamani et al.
Middle East respiratory syndrome coronavirus (MERS-CoV) infects respiratory epithelial cells in humans and camels by binding to dipeptidyl peptidase 4 (DPP4) as its entry receptor. DPP4 is a multifunctional type II membrane protein with a l...
Lethícia R Henriques,Bruna B F Botelho,Roger M Carlson et al.
Lethícia R Henriques et al.
A new level of viral complexity has emerged from the isolation of green algae-infecting chloroviruses from diverse aquatic environments around the world over the past few decades. This study focuses on describing and comparing the genomic f...
First detection of Jingmen tick virus in Corsica with a new generic RTqPCR system [0.03%]
JEY病毒通用RT-qPCR系统的建立及法国科西嘉地区JMN病毒的首次发现
Vincent Cicculli,Agathe M G Colmant,Géraldine Piorkowski et al.
Vincent Cicculli et al.
Jingmen tick virus (JMTV) is a recently discovered segmented RNA virus, closely related to flaviviruses. It was identified for the first time in 2014, in China and subsequently in Brazil. Following this discovery, JMTV-related sequences hav...
A decade of grapevine red blotch disease epidemiology reveals zonal roguing as novel disease management [0.03%]
十年的葡萄红斑病流行研究提出了分区淘汰的新疾病管理方式
M T Flasco,D W Heck,E J Cieniewicz et al.
M T Flasco et al.
Red blotch disease, a threat to the grape industry, is caused by grapevine red blotch virus. This work is the first to study epidemiological patterns in a vineyard over the course of a decade, revealing an increase in disease incidence from...
Juruaça virus taxonomy, tolerance and resistance to infection, and inflammatory response modulation in murine model [0.03%]
尤拉卡病毒的分类学、对感染的耐受性和抗性及其在小鼠模型中对炎症反应的调节作用
Tatyane da Silva Cabral,Natalie Chaves Cayuela,Karina Glazianne Barbosa Carvalho et al.
Tatyane da Silva Cabral et al.
Juruaça virus (JUAV), previously unclassified, was isolated from bats and administered to neonatal and adult BALB/c mice to investigate acute and chronic disease progression. In this study, we conducted genomic sequencing to achieve taxono...