Venezuelan equine encephalitis virus: novel live-attenuated vaccines for inducing complete protective immunity [0.03%]
Kenneth C Elliott,David Saunders,Joseph J Mattapallil
Kenneth C Elliott
Venezuelan equine encephalitis virus (VEEV) is a mosquito-borne alphavirus that causes severe neuroinflammation and fatal infections in some people. Numerous outbreaks of VEEV have been reported in Latin America in the past century. Though ...
SARS-CoV-2 crossreactive B-cells outnumber seasonal coronavirus spike-specific clones at the end of the COVID-19 pandemic [0.03%]
Cristina Gonzalez-Lopez,Muriel Aguilar-Bretones,Julian Reinders et al.
Cristina Gonzalez-Lopez et al.
How B-cell responses towards seasonal human coronaviruses (sHCoVs) impacted those towards SARS-CoV-2 has been widely studied, yet potential reverse effects are ill-defined. We compared sHCoV immune responses between cross-sectional pre-pand...
Ordinary differential equation models of SARS-CoV-2 replication dynamics and antiviral drug efficacies [0.03%]
SARS-CoV-2复制动力学和抗病毒药物有效性的常规微分方程模型
Timon Kapischke,Simon T Herrmann,Luca D Bertzbach et al.
Timon Kapischke et al.
There is a critical need for precise analysis of virus-host interactions to improve our understanding of infection processes. The integration of quantitative measurements with dynamic mathematical modeling has changed how we perceive cellul...
Site-1 protease mediated GPC processing is required for persistence of LCMV Clone 13 [0.03%]
sito-1蛋白酶介导的GPC加工对LCMV克隆13的持续存在是必需的
Ruifeng Zhou,Haydar Witwit,Tingting Ai et al.
Ruifeng Zhou et al.
Most enveloped viruses rely on furin for maturation of their surface glycoprotein. In contrast, mammarenaviruses process their glycoprotein precursor (GPC) using host site-1 protease (S1P), yet the biological implications of this unique rel...
North American Culex pipiens mosquitoes are competent for Usutu virus transmission [0.03%]
北美Culex pipiens蚊子具有Usutu病毒传播能力
Rachel D Persinger,Sarah C Kuchinsky,Chelsea Cereghino et al.
Rachel D Persinger et al.
Usutu virus (USUV, Flaviviridae) is a mosquito-borne, neuroinvasive flavivirus that is maintained in a transmission cycle between Culex spp. mosquitoes and passerine birds. USUV shares close ecological and antigenic similarity to West Nile ...
Prolonged dysregulation and pathological changes in the upper respiratory tract of SARS-CoV-2 infected hamsters [0.03%]
感染新冠病毒的仓鼠呼吸道上皮转录调控及病理变化持续较长时间
Feifei Liu,Yao Xia,Andrew Chak-Yiu Lee et al.
Feifei Liu et al.
Respiratory long COVID symptoms, including dyspnea and breathing pattern disorders, are frequently reported in convalescent COVID-19 patients. Yet the mechanisms driving these persistent respiratory manifestations remain poorly elucidated. ...
COVID-19 boosters restore virus-specific immune responses in kidney transplant recipients unresponsive to primary vaccination [0.03%]
新冠疫苗加强针可恢复肾移植受者的病毒特异性免疫反应
Yvette den Hartog,Yannick van Sleen,Lennert Gommers et al.
Yvette den Hartog et al.
Kidney transplant recipients (KTRs) often exhibit impaired immune responses to vaccination, necessitating multiple doses to obtain sufficient protection from severe disease. This study compared immunological mechanisms underlying the vaccin...
Inequities and global declines in SARS-CoV-2 genomic data availability hinder response to emerging variants [0.03%]
新冠疫情下SARS-CoV-2基因组数据的不平等及全球下降影响了对新变种病毒的应对能力
Emily A Smith,Derek F Fleming,Eve M Lackritz et al.
Emily A Smith et al.
Genomic epidemiology has transformed the way public health scientists detect, monitor, and respond to infectious disease threats such as SARS-CoV-2 on a global scale. Early in the COVID-19 pandemic, vast inequities in whole-genome sequence ...
Study of key residues in MERS-CoV and SARS-CoV-2 main proteases for resistance against clinically applied inhibitors nirmatrelvir and ensitrelvir [0.03%]
研究MERS-CoV和SARS-CoV-2主要蛋白酶中关键残基对临床应用抑制剂奈玛特韦和恩斯特韦的抗性问题
Laura Krismer,Helge Schöppe,Stefanie Rauch et al.
Laura Krismer et al.
The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an epidemic, zoonotically emerging pathogen initially reported in Saudi Arabia in 2012. MERS-CoV has the potential to mutate or recombine with other coronaviruses, thus acquirin...
Immunogenicity and protective efficacy of MERS CoV, NL140422, and HKU4 spike protein nanoparticle vaccines [0.03%]
MERS-CoV、NL14-0422和HKU4刺突蛋白纳米颗粒疫苗的免疫原性及保护效力
Peter J Halfmann,Jeong Soo Lee,Tong Wang et al.
Peter J Halfmann et al.
While vaccines against Middle East respiratory syndrome coronavirus (MERS-CoV) have had substantial preclinical and clinical development, few vaccine candidates target other related viruses with potential for human spillover within the Merb...