A Review of the Evidence of the Toxicity of Chemical Substances Included in the European Union Ambient Air Quality and Drinking Water Directives: Perspectives for Health Impact Assessments [0.03%]
欧盟环境空气质量和饮用水指令中所包含的化学品毒性的证据回顾：对健康影响评估的观点
Hans Orru,Wasif Raza,Francesco Forastiere et al.
Hans Orru et al.
The European Union (EU) Ambient Air Quality Directive (AAQD) and Drinking Water Directive (DWD) are aimed at maintaining and improving air quality and ensuring high standards for potable water across the EU. Besides several other indicators...
Key Molecular Cascade in Indium Tin Oxide Nanoparticle-Induced Pulmonary Fibrosis [0.03%]
铟锡氧化物纳米颗粒诱导肺纤维化的关键分子级联反应
Yun Wang,Xiao He,Zhiyong Zhang
Yun Wang
Dynamic Telomere Length Response to Neurodevelopmental Arsenic Exposure: Insights into Transcriptional Regulation and Neuronal Morphogenesis [0.03%]
动态端粒长度响应神经发育期砷暴露：转录调控和神经元形态发生的启示
Changsong Tian,Qingqing Wu,Fang Chen et al.
Changsong Tian et al.
Developmental exposure to arsenic (As) has been linked to irreversible adverse health outcomes in offspring. However, the underlying molecular mechanisms remain a mystery. Here, maternal mice were exposed to As via drinking water. Subsequen...
Ex Vivo Biosensor Strategy Reveals the Vascular Toxic Effects of Volatile Organic Compounds Derived from Indoor Renovation [0.03%]
体外生物传感器策略揭示室内装修挥发性有机化合物的血管毒性效应
Peihao Yang,Wenting Cheng,Mengruo Wang et al.
Peihao Yang et al.
Volatile organic compounds (VOCs) are widespread indoor gaseous pollutants that are associated with vascular diseases. However, due to methodological limitations, the underlying mechanisms of VOC-induced aortic fibrosis remains unclear. To ...
Exogenous Metals Indirectly Affect Human Semen Quality via Immune Cells at Single-Cell Resolution [0.03%]
单细胞分辨率下外源金属通过免疫细胞间接影响人类精液质量
Nian Liu,Guangming Li,Guohuan Zhang et al.
Nian Liu et al.
Immune modulation is crucial for male reproduction and fertility. Metals and metalloids (metals) have been extensively studied for their immunomodulatory effects. Whether metal exposure affects semen quality through immune modulation is unc...
Cohort Evidence Links Phthalate Exposure to Early Onset of Puberty in Chinese Girls [0.03%]
人群队列证据提示儿童暴露于酞酸盐类化合物可能引起性早熟
Yao Yao,Yuchen Li,Meiting Wei et al.
Yao Yao et al.
Girls' age of onset puberty has decreased globally in recent years. Emerging evidence suggests that exposure to phthalate esters (PAEs) could play a role in this trend. However, the relationship between PAE exposure and pubertal development...
Nitrated Fatty Acids and Susceptibility of COPD to Air Pollution: Evidence from a Randomized Crossover Study [0.03%]
硝化脂肪酸与慢性阻塞性肺疾病患者空气污染易感性关系的随机交叉试验证据
Yan Lin,Ruoxue Chen,Yihui Ge et al.
Yan Lin et al.
Previous studies documented increased nitrative stress and susceptibility to air pollution among individuals with chronic inflammatory conditions. This study examines the role of anti-inflammatory and cardioprotective nitrated fatty acids (...
Prenatal Persistent Exposure to Organophosphate Esters and Early Childhood Brain Development: A Longitudinal Analysis [0.03%]
妊娠期持续接触有机磷酯与儿童早期脑发育的关系：一项纵向研究分析
Liyi Zhang,Pengpeng Wang,Yashuo Xie et al.
Liyi Zhang et al.
Previous studies on the prenatal organophosphate ester (OPE) exposure's effect on children's neurodevelopment have yielded inconsistent results. In this study, we employed a longitudinal approach, capitalizing on multitime-point evaluations...
Energy Burden and Chronic Kidney Disease: A National Study in the United States [0.03%]
美国能源负担与慢性肾脏病的国家研究
Soojin Han,Ming Hu,Youqin Huang et al.
Soojin Han et al.
Energy burden, the inability to afford sufficient energy sources for basic household needs such as heating, cooling, cooking, and lighting, is one of the major social challenges in the U.S. While limited studies have examined these issues s...
Integrating Disease Data and Toxicology Studies to Uncover the Mechanisms of Indium Tin Oxide (ITO) Nanoparticle-Induced Pulmonary Fibrosis and Develop an Adverse Outcome Pathway (AOP) Framework [0.03%]
整合疾病数据和毒理学研究以揭示氧化铟锡(ITO)纳米颗粒诱导肺纤维化的机制并构建不良结局路径(AOP)框架
Chunhui Zhang,Yuna Cao,Jing Qu et al.
Chunhui Zhang et al.
Exposure to indium tin oxide (ITO) nanoparticles (NPs) is strongly correlated with the development of indium lung disease. Preliminary studies have explored mechanisms of ITO NP-induced pulmonary toxicity, but a gap remains in effective met...