Dynamic Associations between Ambient PM2.5 and Its Components and Transitions of Clinical Pregnancy and Adverse Reproductive Outcomes among Participants Treated with ART [0.03%]
空气中的PM2.5及其组分与接受辅助生殖技术治疗的参与者临床妊娠及不良生殖结局之间的动态关联
Zhonghua Ai,Yajun Dong,Xuefei Li et al.
Zhonghua Ai et al.
Evidence remains unknown regarding the associations between PM2.5 and its components exposure and dynamic progression of different assisted reproductive outcomes in participants undergoing fresh embryo transfer. We included infertile partic...
FTO-ACKR3 Axis Regulates Polycyclic Aromatic Hydrocarbons-Induced Asthma Attacks via AhR-Mediated m6A RNA Methylation [0.03%]
FTO-ACKR3轴通过AhR介导的m6A RNA甲基化调节多环芳烃诱导的哮喘发作
Shengbin Liu,Jiangzhou Chu,Jinxiu Xin et al.
Shengbin Liu et al.
Airborne polycyclic aromatic hydrocarbons (PAHs) are increasingly linked to asthma onset and exacerbation, yet their molecular mechanisms remain unclear. Building on our previous finding that PM2.5 alters m6A RNA methylation, we hypothesize...
Clinical Human-Derived Pathogen Signatures Captured by SERS and Deep Learning for Environmental Exposure Risk Assessment [0.03%]
基于表面增强拉曼光谱和深度学习的人源病原体指纹识别与环境风险评估研究
Zhonghua Shen,Linguo Xie,Yuwei Hou et al.
Zhonghua Shen et al.
Microbial contamination and antibiotic-resistant bacteria (ARB) pose significant threats to environmental ecosystems, particularly in regions lacking adequate sanitation. Urinary pathogens of human origin, frequently detected in contaminate...
Concentration-Specific Neurotoxic Pathways of Tetrabromobisphenol A and Tetrabromobisphenol A Bis(2-Hydroxyethyl Ether) in Zebrafish Larvae [0.03%]
四溴双酚A和四溴双酚A双（2-羟乙基）醚在斑马鱼幼虫中的浓度特异性神经毒性途径
Hai Xu,Xing Dong,Wenhui Qiu et al.
Hai Xu et al.
Tetrabromobisphenol A (TBBPA) and its derivative, TBBPA bis-(2-hydroxyethyl ether) (TBBPA-BHEE), are widely used brominated flame retardants commonly detected in environmental media and biota. While regulatory bodies deem these chemicals un...
Molecular Landscape Remodeling Unravels the Cross-Links of Microplastics-Induced Lipidomic Fluctuations, Nutrient Disorders and Energy Disarrangements [0.03%]
分子景观重塑解开微塑料诱导的脂质组波动、营养障碍和能量失调之间的相互作用
Miao Wang,Jing Wang,Xinglin Sun et al.
Miao Wang et al.
Microplastics are emerging contaminants that pose health risks. They can cause hepatic lipid interventions, but the underlying mechanisms require investigation. This study assessed the retention of polypropylene microplastics in mouse liver...
Sex-Specific Biological Aging-Related Lipidomic Profiles Mediate the Impact of Urinary Polycyclic Aromatic Hydrocarbon Exposures on Cognitive Function in Healthy Older Adults [0.03%]
尿多环芳烃暴露影响健康老年人认知功能的性别特异性脂质组学介质作用研究
Huimin Ren,Wanying Shi,Xiaojie Guo et al.
Huimin Ren et al.
Emerging evidence suggests that exposure to polycyclic aromatic hydrocarbons (PAHs) may exacerbate cognitive deterioration and biological aging, but the biomolecular mechanisms, particularly those driving sex-specific vulnerability, remain ...
Hepatotoxicity Prediction and Multi-omics Reveal Mitochondrial and Lipid Metabolic Dysregulation in PM2.5-Induced Liver Fibrosis [0.03%]
肝毒性预测及多组学揭示PM2.5诱导的肝脏纤维化中的线粒体和脂质代谢紊乱
Hiu-Lok Ngan,Jialing Zhang,Yi Chen et al.
Hiu-Lok Ngan et al.
Prolonged exposure to fine particulate matter (PM2.5) has been linked to chronic liver injury and cancer. However, an alternative risk assessment method to prospective longitudinal studies of exposome-metabolome interactions for liver infla...
Ultraviolet Absorbers Exhibit Dual Modulatory Effects on Oxidative Stress Biomarkers in Exposed Populations [0.03%]
紫外线吸收剂对暴露人群氧化应激生物标志物具有双重调节作用
Lu Bai,Zhuangzhuang Feng,Xu Zhang et al.
Lu Bai et al.
Health risks due to ultraviolet absorbers (UVAs), which are emerging contaminants prevalent in plastics and consumer products, are poorly understood. This study quantified 10 UVA congeners in urinary samples from 254 Beijing residents aged ...
PM2.5 Composition Exposure and Cardiovascular Disease: A Multicohort Study Integrating Disease Incidence and Biomarkers [0.03%]
基于疾病发病和生物标志物的多队列研究：PM2.5组分暴露与心血管病关系
Jiajun Luo,Yuqing Yang,Zhihao Jin et al.
Jiajun Luo et al.
The chemical composition of PM2.5 differentially influences cardiovascular risk, but evidence integrating clinical and subclinical end points is limited. Here, we evaluated the long-term exposure to seven PM2.5 components in 255,394 All of ...
Resistance Gene Dynamics, Biogeochemical Coupling, and Ecological Risks in Sediments of Anthropogenically Impacted Lake Wetlands in China [0.03%]
中国人工影响湖泊湿地沉积物中抗性基因动态、生化耦合及生态风险研究
Chengzhi Mao,Yunfeng Wang,Xinghao Li et al.
Chengzhi Mao et al.
Antibiotic resistance is a growing global threat to both public health and ecosystem stability. While the "One Health" framework emphasizes the need to monitor antibiotic resistance genes (ARGs) across diverse environments worldwide, the ri...