Imbalance of the Arachidonic Acid Metabolism in Neuroinflammation and Cognition Caused by Manganese Exposure: Downregulation of 15d-PGJ2 Levels and Validation of MMP9 as a Target [0.03%]
manganese暴露引起的神经炎症和认知中花生四烯酸代谢失衡：15d-PGJ2水平下调及MMP9作为靶点的验证
Junrou Zhang,Luli Wu,Gaoman Zhang et al.
Junrou Zhang et al.
Exposure to manganese (Mn) is known to induce cognitive dysfunction, but the underlying processes involving neuroinflammation and arachidonic acid (AA) metabolism remain incompletely understood. This study integrates human epidemiological d...
Disinfection Byproducts, Oxidative Stress, and Sleep Quality among Healthy Chinese Men [0.03%]
中国健康男性中的消毒副产物、氧化压力与睡眠质量的研究
Shiyu Xu,Guangming Li,Vicente Mustieles et al.
Shiyu Xu et al.
Toxicological studies show that disinfection byproducts (DBPs) adversely affect neurological and psychiatric symptoms, which have been linked to poor sleep quality. This cohort study explored the associations between DBP exposure, oxidative...
Ambient PM2.5 and Its Components Associated with Dynamic Progression from Different Blood Pressure States to Cardiovascular Diseases and Mortality: The GOLD-Health Cohort [0.03%]
环境PM2.5及其组分与不同血压状态的动态变化进展至心血管疾病和死亡的关系：来自GOLD-健康队列的证据
Manting Rao,Weiquan Lin,Liying Luo et al.
Manting Rao et al.
The relationships between fine particulate matter (PM2.5) and the risk of hypertension (HTN) and cardiovascular disease (CVD) have been well documented. However, the associations between specific chemical constituents of PM2.5 and the dynam...
Gestational Trichloroacetic Acid Exposure Induces Miscarriage by Disrupting Iron Homeostasis in Trophoblasts via the KEAP1-NRF2 Pathway [0.03%]
妊娠期间三氯乙酸暴露通过KEAP1-NRF2途径破坏胎盘滋养细胞铁稳态诱导流产
Yijun Zhang,Hanyu Rao,Zhiyi Pan et al.
Yijun Zhang et al.
Trichloroacetic acid (TCAA) is one of the most commonly detected non-volatile disinfection byproducts (DBPs) in public water supplies. Previous epidemiological studies have established associations between TCAA exposure and elevated risks o...
Early-Life Ozone Exposure and Childhood Allergic Rhinitis: Critical Exposure Windows, Exposure-Response Relationships, and Protective Modifiers [0.03%]
早期臭氧暴露与儿童过敏性鼻炎：关键暴露时期、剂量效应关系及保护因素
Tianyi Chen,Zhiping Niu,Dan Norback et al.
Tianyi Chen et al.
Childhood allergic rhinitis (AR) is associated with ozone (O3) exposure, yet the sensitive exposure window (SEW) remains unclear. This multicenter survey of 38,176 children aged 3-6 years across 7 Chinese cities (2019-2020) estimated satell...
Respiratory Exposure to Lithium Nickel Manganese Cobalt Oxide Particles: Evidence for Toxicity and Disruption of Metal Homeostasis in Mice [0.03%]
锂镍锰钴氧化物颗粒的呼吸道暴露：对小鼠毒性和金属稳态破坏的证据
Xu Zhang,Xiu Ye,Qi Sun et al.
Xu Zhang et al.
Lithium nickel manganese cobalt oxide (NMC) is a widely used cathode material in lithium-ion batteries. However, its increasing utilization has raised concerns about environmental contamination and potential health risks, underscoring the n...
Coke Oven Emission Exposure Triggers Malignant Transformation of Lung Epithelial Cells by SFTA1P-Dependent Alteration of Acetyl-CoA Metabolism [0.03%]
苯并(a)芘通过依赖SFTA1P的乙酰辅酶A代谢改变诱发肺上皮细胞恶性转化
Qiang Ju,Xinmei Li,Zhaoxu Wu et al.
Qiang Ju et al.
Exposure to coke oven emissions (COEs) is an important environmental factor in lung cancer. A previous study revealed that 20 μg/mL COE exposure for 120 days could induce malignant transformation of lung epithelial cells. However, the unde...
Prenatal Metal Exposome Reprograms Neonatal Metabolism: Trimester-Dependent Effects on Amino Acid and Carnitine Networks [0.03%]
孕期金属暴露组重新编程新生儿代谢：妊娠期依赖性影响氨基酸和肉毒碱网络
Xinning Chen,Yulian Liao,Yubing Ma et al.
Xinning Chen et al.
Pregnant women and newborns are highly vulnerable to metal exposure. However, there is limited evidence regarding how prenatal metal exposome influences newborn metabolic programming. This prospective cohort in 2022-2023 analyzed 432 mother...
Metabolic Reprogramming Bridges Environmental Exposure and Tinnitus Severity: Evidence from AI-Driven Serum Multiomics [0.03%]
代谢重塑连接环境暴露和耳鸣严重程度：来自人工智能驱动的血清多组学证据
Tingting Qian,Ge Wang,Peifan Li et al.
Tingting Qian et al.
Tinnitus is a prevalent auditory disorder with poorly understood links between environmental exposure and disease, complicating objective diagnosis and intervention. In a graded observational cohort with documented occupational noise histor...
Guadalupe Lopez-Nava,Lucie Michel,Giacomo Dell&#x;Omo et al.
Guadalupe Lopez-Nava et al.
Laboratory studies show that mercury (Hg) and per- and polyfluoroalkyl substances (PFAS) can impair mitochondrial bioenergetics, which is a vital process for cellular energy production. However, their effects on wild, free-living organisms ...