Environmental Consequences of Anthropogenic Pollution: Non-antibiotic-Drug-Driven Antibiotic Resistance Selection in a Model Aquatic Ecosystem [0.03%]
人为污染的环境后果：模型水生生态系统中非抗生素药物驱动的抗生素抗性选择压力
Concepcion Sanchez-Cid,Stanislava Vrchovecká,Emilie Dehon et al.
Concepcion Sanchez-Cid et al.
Non-antibiotic drugs (NADs) used in human therapy may induce antibiotic resistance selection and dissemination in vitro. However, the potential risks of antibiotic resistance emergence associated with environmental NAD pollution have not be...
Pseudomonas aeruginosa Activates the NOD-like Receptor Signaling Pathway by Targeting Nasopharyngeal Cells throughout the Whole Respiratory Tract [0.03%]
不动杆菌通过靶向呼吸道上呼吸道细胞激活NLR信号通路
Caiqing Peng,Guiying Li,Linghui Peng et al.
Caiqing Peng et al.
Bioaerosols are commonly present in air, and the exposure of bacteria in bioaerosols may lead to allergic reactions and respiratory diseases. However, precise mechanisms underlying the impact of pathogenic bacteria on respiratory health rem...
Neurotoxicity of Micro- and Nanoplastics: A Comprehensive Review of Central Nervous System Impacts [0.03%]
微塑料和纳米塑料的神经毒性：中枢神经系统影响的全面综述
Qianwen Ma,Jialin Lei,Yanting Pang et al.
Qianwen Ma et al.
Micro- and nanoplastics (MNPs), originating from plastic wastes degradation, industrial processes, and textile fiber shedding, persist in the environment and act as carriers of hazardous substances, posing significant global health risks. G...
Machine Learning Models for High-Throughput Screening of Obesogens Based on Pathway Network [0.03%]
基于通路网络的肥胖干扰物高通量筛选机器学习模型
Xiaoqing Wang,Yang Huang,Fei Li et al.
Xiaoqing Wang et al.
Metabolism-disrupting chemicals increase the incidence of obesity through diverse signaling pathways. It is critical to prioritize potential obesogenic factors and systematically profile their modes of action. Here, based on adverse outcome...
Occurrence Patterns of Bisphenol Analogues in Human Blood, Subcutaneous Fat, and Visceral Fat [0.03%]
双酚类类似物在人体血液、皮下脂肪和内脏脂肪中的出现规律
Peng Jiao,Yue Gao,Aijing Li et al.
Peng Jiao et al.
Bisphenol analogues (BPs) are well-established endocrine-disrupting chemicals (EDCs). While they are generally not classified as persistent organic pollutants due to their relatively rapid metabolism and urinary excretion, a fraction can ac...
Oral Intake of Plasticizer Di-(2-ethylhexyl) Phthalate Disrupts Cerebellar Myelination via Thyroid Signaling in Aging Mice [0.03%]
增塑剂邻苯二甲酸二异辛酯通过甲状腺信号干扰小鼠衰老过程中小脑髓鞘化
Qu-Nan Wang,Fengjie Yang,Xianyan Wang et al.
Qu-Nan Wang et al.
Aging is a significant global health challenge, with neurodegenerative diseases severely affecting the quality of life in the elderly. Di-(2-ethylhexyl) phthalate (DEHP), a commonly used plasticizer in food packaging, has been identified as...
Advancing Point-of-Care Healthcare Diagnostics to Tackle Future Outbreaks and Pandemics: Nanotechnology-Driven Developments and Impact on Rapid Pathogen Detection [0.03%]
纳米技术驱动的即时医疗诊断技术的发展及对快速病原体检测的影响：应对未来疫情和大流行病
Naresh Mandal,Bidhan Pramanick,Tarun Kanti Bhattacharyya et al.
Naresh Mandal et al.
Organoid for Air Pollution Toxicity Assessment: Advances and Environmental Applicability [0.03%]
类器官在空气污染毒性评估中的进展及应用前景
Jia Yin,Di Wu,Xiu Chen et al.
Jia Yin et al.
Air pollution is the leading environmental risk to human health. Toxicological studies indicate the toxic effects of air pollution on human disease according to in vitro cell lines and in vivo models. However, these evaluation tools have la...
Prenatal Exposure to PM2.5 Increased Vulnerability to a Second Hit of a High-Fat Diet in Mouse Offspring [0.03%]
孕期暴露于PM₂.₅增加了后代对高脂饮食诱导肥胖的易感性
Limin Wang,Renjie Hu,Zhenghong Yao et al.
Limin Wang et al.
Emerging evidence indicates that prenatal exposure to fine particulate matter (PM2.5) may program metabolic syndrome (MS) in adult offspring. However, the metabolic response to the second hit of a high-fat diet (HFD) (prenatal PM2.5 exposur...
Malignant Transformation of Human Uroepithelial Cells Induced by Long-Term Exposure to a Disinfection Byproduct2,6-Dichlorobenzoquinone [0.03%]
消毒副产物2，6-二氯苯醌长期诱导人尿路上皮细胞恶性转化
Tongtong Xiang,Chang Wang,Yasmine Rais et al.
Tongtong Xiang et al.
Halobenzoquinones (HBQs), a class of water disinfection byproducts (DBPs), have emerged as potential bladder carcinogens. However, evidence regarding the long-term health effects of HBQ exposure and their potential to induce malignant trans...