PM2.5-Induced Multinucleation of Bronchial Epithelial Cells due to Microtubule Overacetylation and Disruption of Microtubule-Associated Proteins [0.03%]
PM2.5通过组蛋白乙酰化干扰微管结合蛋白引起支气管上皮细胞多核化
Liyan Xiao,Jinyan Pang,Zhiling Guo et al.
Liyan Xiao et al.
The formation of multinucleated cells is associated with abnormal mitosis, which can lead to uncontrolled cell proliferation and even malignant transformation due to the continuous increase in chromosomal instability. Our previous study was...
Multidimensional Unraveling Insights from an Enzyme-Nanozyme Cascade-Based Electrochemical Biosensor for Screening Microplastic Neurotoxicity [0.03%]
基于酶-纳米酶级联的电化学生物传感器筛选微塑料神经毒性的多维解析
Yifei Xing,Xuehan Wei,Xu Liang et al.
Yifei Xing et al.
Accurate quantification of biomarkers is crucial for evaluating the neurotoxicity of pollutants. Traditional detection methods, albeit important, are limited by single analytical indicators and time-consuming procedures, which lead to disto...
Weather-Specific Individual Exposure to Organic Contaminants in Fine Particulate Matter by Nontarget Screening and Risk Prioritization [0.03%]
基于非目标筛查和风险优先级划分的细颗粒物中有机污染物的个体暴露量及其气象特异性研究
Yujue Yang,Guorui Liu,Zhiyong Xie et al.
Yujue Yang et al.
Respiration exposure evaluation to numerous organic contaminants in fine particle matter (PM2.5) is essential for health risk characterization. There is still a lack of understanding of the individual exposure to airborne pollutants under d...
Effect of Co-Exposure to Temperature and Fine Particulate Matter on Metabolomic and Immune Processes among Chinese Women of Childbearing Age [0.03%]
温度和细颗粒物暴露对中国育龄妇女代谢组学和免疫过程的影响研究
Nan Li,Ming Jin,Changxin Lan et al.
Nan Li et al.
Short-term exposures to temperature and fine particulate matter (PM2.5) have been associated with metabolomic perturbations. However, their combined effect on the metabolome has not been evaluated. We investigated the effect of short-term c...
Black Phosphorus Nanosheets Penetrate the Blood-Testis Barrier and Induce Reproductive Toxicity in Male Mice [0.03%]
黑磷纳米片穿透血睾屏障引起小鼠生殖毒性
Suhua Jiang,Fengkai Ruan,Fucong Zhang et al.
Suhua Jiang et al.
Black phosphorus nanosheets (BPNSs), as an emerging subclass of two-dimensional (2D) nanomaterials, have exhibited extensive applicability in electronics, optoelectronics, and medical sciences. However, its expanding application in diverse ...
Nontarget Screening and Health Risk of Hazardous Volatile and Semivolatile Organic Compounds in Premade Food Using a Molecular Network Assisted Data Collation Workflow [0.03%]
基于分子网络的预包装食品中危害物筛查及健康风险评估
Jiyuan Weng,Yuqi Wang,Lei Zhang et al.
Jiyuan Weng et al.
Premade foods have been popular in recent years, but compounds from foods and their packaging may be harmful. A nontargeted screening method was developed for analysis of volatile and semivolatile organic compounds. Fully automated data for...
Neighborhood Greenspace Enhances Cardiopulmonary Function in Healthy Older Adults: A Multiomics Analysis from the BAPE Study [0.03%]
基于BAPE研究的多组学分析：社区绿地可增强健康老年人的心肺功能
Weiju Zhou,Jiuxuan Gao,Xiaojie Guo et al.
Weiju Zhou et al.
Urban greenspace measured by remote sensing has been linked to population health benefits, yet evidence on cardiopulmonary effects at the microenvironmental street level and related molecular mechanisms in older adults remains limited. We c...
Identifying Chemicals of Health Concern in Hair Extensions Using Suspect Screening and Nontargeted Analysis [0.03%]
使用可疑筛查和非目标分析识别发 extensions 中的有害化学物质
Elissia T Franklin,Kristin Favela,Radonna Spies et al.
Elissia T Franklin et al.
Chemical exposures from hair extensions pose a growing public health concern due to their poorly characterized composition and limited regulatory oversight. Extensions are commonly made of human hair, other natural fibers, or synthetic fibe...
Prenatal Exposure to PFOA Induces Ovarian Function Impairment via the Disruption of the PPARγ/ANGPTL4 Pathway [0.03%]
孕期暴露于全氟辛酸使过氧化物酶体增殖激活受体γ转录因子和血管生成素-like蛋白4表达异常，从而损害卵巢功能
Tongyun Qi,Huiyu Fan,Wenxian Xu et al.
Tongyun Qi et al.
Perfluorooctanoic acid (PFOA) has been implicated in female reproductive toxicity, while its long-term effects of prenatal exposure remain unclear. Herein, we conducted a comprehensive NHANES analysis to estimate the Hazard Ratio (HR) of ea...
High-Throughput Suspect Screening Reveals Widespread Pesticide Exposure in Early Childhood [0.03%]
高通量嫌疑筛查发现农药在幼儿期的广泛暴露现象
Haoduo Zhao,Yun-Chung Hsiao,Chih-Wei Liu et al.
Haoduo Zhao et al.
Characterization of the human exposome, the totality of exposure, provides unprecedented insights into the role of broad environmental factors in human diseases. Environmental exposures during development periods are increasingly recognized...