Ozone Exposure Induces Anemia via Immune-Inflammatory Disruption of Erythroid Homeostasis [0.03%]
臭氧暴露通过免疫炎症干扰红细胞稳态诱导贫血
Yang Wang,Huifeng Yue,Nan Sang
Yang Wang
Ground-level ozone (O3), a major ambient air pollutant, is epidemiologically linked to anemia, but its mechanisms remain unclear. This study employed integrated phenotypic, histopathological, and transcriptomic analyses to explore the molec...
Microplastics and Nanoplastics Cause Thyroid Dysfunction in Adolescent Mice through the Intestinal Microbiota-Mediated Hypothalamus-Pituitary-Thyroid Axis [0.03%]
微塑料和纳米塑料通过肠道微生物群介导的下丘脑-垂体-甲状腺轴导致小鼠甲状腺功能障碍
Jinpeng Zhang,Jiaoyang Ji,Xiaowei Dai et al.
Jinpeng Zhang et al.
Polypropylene (PP) and poly-(ethylene terephthalate) (PET) plastic products are widely used in diet packaging and may generate microplastics (MPs) and nanoplastics (NPs) during use. However, their effects and mechanisms on causing endocrine...
Repeat Prolonged Chlorination at Low Dose Induces Chlorine Tolerance in Legionella pneumophila via Viable but Non-culturable State [0.03%]
低剂量重复连续氯化作用下通过休眠状态诱导Legionella pneumophila产生抗药性
Xiaofei Yuan,Yan Zheng
Xiaofei Yuan
Chlorine-resistant Legionella pneumophila, the causative agent of fatal pneumonia, poses a major global public health threat. However, the mechanistic basis for this pathogen's resistance evolution remains elusive. Our study demonstrates th...
Influence of Air Pollution Exposure on the microRNA Content of Neuronal Extracellular Vesicles in Subjects Affected by Major Depressive Disorder [0.03%]
暴露于空气污染对重大抑郁障碍受试者神经元外泌体microRNA含量的影响
Paola Monti,Elisa Borroni,Rachele Matsagani et al.
Paola Monti et al.
Major depressive disorder (MDD) has been recently linked to air pollution exposure; nevertheless, the biological mechanisms underlying this association remain underinvestigated. Air pollution might modulate the microRNA (miRNA) content of n...
Individual and Joint Effect of Particulate Matter and Night-Time Temperature on Sperm Quality: A Large Retrospective Cohort Study in China [0.03%]
基于中国的大型回顾性队列研究：PM与夜间温度对精子质量的个体效应和联合作用
Junjie Liu,Ting Xu,Tingting Dai et al.
Junjie Liu et al.
The joint effect of particulate matter (PM) and night-time temperature on sperm quality remains unclear. We aimed to investigate the individual and joint effects of PM and night-time temperature on sperm quality. This population-based cohor...
Determining Location-Specific Thresholds for Heat Warning Systems to Mitigate Heatstroke Mortality in Japan [0.03%]
确定日本热预警系统的地点特定阈值以减轻中暑死亡事件
Vera Ling Hui Phung,Yasushi Honda,Kazutaka Oka et al.
Vera Ling Hui Phung et al.
The current nationwide wet bulb globe temperature (WBGT) threshold (33 °C) of Japan's heat warning system (HWS) does not adequately account for regional variations in heat sensitivity and heatstroke mortality. In this study, we aimed to de...
Multiomics Reveals Mitochondrial and Metabolic Perturbations Underlying Cyclotriphosphazene-Induced Lung Injury [0.03%]
多组学揭示环三磷氮烯致肺损伤的线粒体和代谢改变
Changjie Li,Shanshan Wang,Xiangrong Chen et al.
Changjie Li et al.
Cyclotriphosphazenes (CTPs), widely used as flame-retardant electrolyte additives in lithium batteries, have raised significant environmental and health concerns due to their potential release and human exposure. However, the toxicological ...
Developmental Mono(2-ethylhexyl) Phthalate Exposure Impairs Offspring Neurobehavior through Suppression of CYP450 Transcriptional Pathways [0.03%]
单酚暴露通过抑制CYP450转录途径损害子代神经行为发育
Jingcun Dong,Jia Yin,Shuang Liu et al.
Jingcun Dong et al.
Phthalates, ubiquitous environmental contaminants, pose substantial risks to neurodevelopment, yet the mechanisms underlying their toxicity remain largely unknown. This study demonstrates that developmental exposure to mono-(2-ethylhexyl) p...
The China Birth Cohort-Environmental and Genetic Factors (CBC-EG) Study: Design, Aims, Protocol, Findings, and Prospects [0.03%]
中国出生队列研究——环境和遗传因素（CBC-EG）：设计、目的、方案、发现及展望
Jiaqi Zhu,Juan Chen,Kai Zhao et al.
Jiaqi Zhu et al.
Early life, including the embryonic period, is particularly vulnerable to environmental exposures. Previous studies have largely focused on the relationship between individual environmental factors and population health. In reality, individ...