The multiple mechanisms and modes of cell death after acetaminophen overdose [0.03%]
药物过量引起的细胞死亡的多种机制和方式
Hartmut Jaeschke,Anup Ramachandran
Hartmut Jaeschke
Acetaminophen (APAP)-induced liver injury and acute liver failure is a significant clinical problem worldwide; in addition, APAP overdoses in animals or in cell culture are used as popular models to study drug-induced liver injury mechanism...
Finn Jung,Victor Sánchez,Annette Brandt et al.
Finn Jung et al.
Excessive alcohol intake is still among the leading causes of chronic liver diseases. Epidemiological studies suggest that per capita consumption of alcohol from various alcohol beverages e.g., beer, wine, or spirits, differs markedly betwe...
The intermicrovillar adhesion complex in gut barrier function and inflammation [0.03%]
肠道屏障功能和炎症中的肠微褶复合体的作用机制研究
Bernadette Mödl,Katy Schmidt,Doris Moser et al.
Bernadette Mödl et al.
The surface of intestinal epithelial cells is covered by the brush border, which consists of densely packed cellular extrusions called microvilli. Until recently, microvilli have not been known to be interconnected. In 2014, a protein compl...