Natural Selection-Guided ACE2-Targeted Molecular Imaging: A New Paradigm for PET Tracer Development [0.03%]
自然选择指导的ACE2靶向分子成像：PET示踪剂开发的新范例
Rou Li,Jie Li,Shuai Xue et al.
Rou Li et al.
Angiotensin-converting enzyme 2 (ACE2) has been identified as a biomarker and a promising therapeutic target in several diseases. The noninvasive visualization of in vivo ACE2 mapping is urgent for disease guidance and treatment assessment....
Silicon Rhodamine-Based Fluorescence Lifetime Probe for Dynamics Mapping Lysosomal Oxidative Stress [0.03%]
基于硅罗丹明的用于溶酶体氧化应激动力学映射的荧光寿命探针
Qingshuang Xu,Yiyan Zhang,Yuxun Tang et al.
Qingshuang Xu et al.
Lysosomes are organelles responsible for cellular degradation and recycling. The detection of changes in the lysosomal microenvironment, such as viscosity, oxidative stress, and pH value, as well as their interactions among dynamic organell...
A Caspase-3-Activatable Near-Infrared AIEgen for Tumor Apoptosis Imaging In Vivo [0.03%]
一种激活型 caspase-3 纳米探针及其制备方法和应用
Lingling Xu,Yuanyuan Jin,Zhanjun Yang et al.
Lingling Xu et al.
Near-infrared (NIR) fluorescence imaging of tumor caspase-3 activity can be applied for real-time monitoring of the therapeutic effect of an anticancer drug in vivo. Aggregation-induced emission luminogens (AIEgens) are highly sensitive, un...
Xinrui Song,Baris Turkbey,Soroush Rais-Bahrami et al.
Xinrui Song et al.
Transrectal ultrasound (TRUS) is widely used for guiding prostate biopsy due to its real-time imaging capabilities. However, ultrasound (US) lacks sensitivity for detecting prostate cancer, necessitating the integration of preoperative magn...
Xinyu Deng,Hyeon Jeong Lee,Delong Zhang
Xinyu Deng
Feature Selection and Hyperparameter Optimization for Machine Learned Classification of 3D Single-Particle Tracking [0.03%]
三维单粒子追踪机器学习分类的特征选择与超参数优化
Jagriti Chatterjee,Subhojyoti Chatterjee,Emil Gillett et al.
Jagriti Chatterjee et al.
Understanding diffusion in charged and crowded media is crucial for solving a wide range of biological and materials challenges. Classifying diffusion by traditional methods such as mean square displacement in three-dimensional single-parti...
Perspective on Ionophore-Based Ion-Selective Nanosensors for pH-Independent Quantitative Lysosomal Calcium Imaging [0.03%]
基于离子载体的离子选择性纳米传感器在pH不依赖型定量溶酶体钙成像中的应用展望
Tsun Kit Li,Wai Yin Lee,Wei Wang et al.
Tsun Kit Li et al.
Lysosomes, the acidic degradative hubs of cells, are increasingly recognized as critical regulators of calcium signaling, with dysregulation linked to neurodegenerative diseases and lysosomal storage disorders. However, quantifying lysosoma...
Preclinical Evaluation Study of 68Ga-Labeled PSMA-Targeted Dimer Probe [0.03%]
68镓标记PSMA靶向二聚体探针的药物I期试验的临床前评估研究
Quan Xie,Jichen Yang,Jing Li et al.
Quan Xie et al.
The development of tracers targeting prostate-specific membrane antigen (PSMA) has great significance for improving the diagnosis and treatment of prostate cancer (PCa). In this study, a dimeric PSMA-targeting ligand, PSMA-DIM, has been des...
Angeliki Birmpili,Ron M A Heeren,Rob J Vreeken et al.
Angeliki Birmpili et al.
Accurate diagnosis is of great importance in all medical fields, and dermatology is no exception. Among the various routes available to clinicians, medical tests based on imaging properties have become a cornerstone for the assessment of sk...
Multidimensional Tracking and Clustering of Electrochemical Reactions in the Positive Electrode of Lithium-Ion Batteries via Operando X‑ray Nanoscale Chemical Imaging [0.03%]
基于原位纳米级化学成像的锂离子电池正极电化学反应的多维追踪及聚类研究
Hideshi Uematsu,Nozomu Ishiguro,Kosuke Kawai et al.
Hideshi Uematsu et al.
Understanding heterogeneous electrochemical reactions in the positive electrode of the Li-ion battery is essential for improving battery capacity and fast charging capabilities. Observing these reactions under operando conditions is essenti...