Regulatory B cells and SIVA1-LAG3 immune suppression predict poor prognosis in prostate cancer [0.03%]
前列腺癌中的调控性B细胞和SIVA1-LAG3免疫抑制预示不良预后
Weicheng Tian,Yize Li,Jinchuang Li et al.
Weicheng Tian et al.
Prostate cancer (PCa) is among the most prevalent malignancies affecting men globally. The immunosuppressive characteristics of the tumor microenvironment significantly hinder the effectiveness of immunotherapeutic strategies. B cells have ...
Chronic inorganic arsenic exposure impairs locomotor performance and socio-affective behavior in zebrafish [0.03%]
慢性无机砷暴露损害斑马鱼运动表现和社会情绪行为
Cătălina Ionescu,Petru Fabian Lungu,Ionut-Alexandru Chelaru et al.
Cătălina Ionescu et al.
Inorganic arsenic (iAs) is a prevalent and highly toxic environmental contaminant, yet its neurotoxic effects on aquatic organisms are not well characterized. This study examines whether chronic exposure to environmentally relevant concentr...
Oxytocin modulates social preference and anxiety-like locomotor behavior in albino and non-albino zebrafish [0.03%]
催产素调节白化和非白化斑马鱼的社会偏好和类似焦虑的运动行为
Ana Maria Danila,Alexandra Savuca,Mircea-Nicusor Nicoara et al.
Ana Maria Danila et al.
Socio-emotional and exploratory behaviors in zebrafish (Danio rerio) are shaped by conserved neuromodulators such as oxytocin (OXT), yet phenotypic variation (e.g., albinism) may modify sensitivity to OXT-dependent regulation. Here, we test...
Claudin 18.2, IDH1, and neutrophil-to-lymphocyte ratio as prognostic biomarkers in unresectable pancreatic ductal adenocarcinoma receiving first-line chemotherapy [0.03%]
克劳德因18.2、IDH1及中性粒细胞与淋巴细胞比值作为不可切除型胰腺导管腺癌一线化疗预后生物标志物的研究
Ebru Karcı,Ferhat Ozden,Elif Kuzucular et al.
Ebru Karcı et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with few effective treatment options. This study investigates the prognostic significance of claudin 18.2 (CLDN18.2), isocitrate dehydrogenase-1 (IDH1) expression, an...
Low-dose metformin in the brain: A focused review of its novel mechanism of glucose lowering in type 2 diabetes [0.03%]
低剂量二甲双胍在脑内的作用：其降低2型糖尿病血糖的新型机制的专题回顾
Zain Ahmad,Saghir Akhtar
Zain Ahmad
Metformin remains the first-line pharmacological therapy for type 2 diabetes mellitus (T2DM). While its glucose-lowering effects have primarily been attributed to peripheral actions, evidence indicates that it also crosses the blood-brain b...
Structural MRI phenotyping in Alzheimer's disease: Comparison of visual rating scales, volumetry, and cortical thickness in a Serbian single-centre cohort [0.03%]
阿尔茨海默病的结构磁共振表型分析：在一个塞尔维亚单一中心队列中视觉评分量表、体积和皮层厚度的比较
Aleksandra Aracki-Trenkic,Milica Živanović,Vuk Milošević et al.
Aleksandra Aracki-Trenkic et al.
Alzheimer's disease (AD) is characterized by a heterogeneous clinical course, and magnetic resonance imaging (MRI)-based phenotyping has increasingly been utilized to elucidate this variability. The literature recognizes four predominant MR...
Higher serum PFDA is associated with increased non-melanoma skin cancer odds in NHANES 2003-2018 [0.03%]
基于NHANES 2003-2018数据的全氟己烷磺酸与非黑色素性皮肤癌的关系研究
Sundus Siddiqui,Hiba Siddiqui,Karim Nagi et al.
Sundus Siddiqui et al.
Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent chemicals commonly employed in heat- and water-resistant applications. Experimental evidence indicates a biological plausibility for PFAS-related carcinogenic effects...
Prognostic nutritional index predicts 1-year hospitalization and mortality in outpatients with cirrhosis [0.03%]
营养指数可预测失代偿期肝硬化门诊患者的住院率和一年生存率
Ayşe Karaduru Avcı,Zeynep Gök Sargın,Fatih Sargın
Ayşe Karaduru Avcı
Malnutrition is prevalent in patients with cirrhosis and is linked to negative clinical outcomes. However, research on the prognostic nutritional index (PNI) and the burden of hospitalization over one year in stable outpatients remains limi...
Intraoperative ultrasound in breast-conserving surgery for palpable breast cancer: Association with surgical margins and resection volume [0.03%]
术中乳腺癌保留乳房手术中的超声波检查与外科边缘和切除体积的关系分析
İsmail Zihni,Osman Cem Yilmaz,Meliha Ülkü Güzel
İsmail Zihni
Accurate determination of surgical margins is a crucial aspect of breast-conserving surgery (BCS) for early-stage breast cancer. Traditionally, tumor localization has been performed through palpation followed by frozen section analysis. How...
Long non-coding RNAs in neurodegenerative diseases - Molecular mechanisms, liquid biopsy biomarkers, and therapeutic targets: A review [0.03%]
长非编码RNA在神经退行性疾病中的作用：分子机制、液体活检生物标志物和治疗靶点：综述文章
Yipeng Cheng,Mingyue Qiu,Zhijie Yu et al.
Yipeng Cheng et al.
Neurodegenerative diseases (NDDs), such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD), are age-related disorders characterized by progressive neuronal loss, cogniti...