Biologic therapy in geriatric psoriasis: 6-month real-world data on PASI, inflammatory indices, and hepatitis B/tuberculosis safety [0.03%]
生物制剂治疗老年银屑病的疗效及安全性：PASI、炎症指标以及乙肝/结核感染6个月真实世界数据
Esranur Ünal,Beste Pakırdaşı,Selma Emre et al.
Esranur Ünal et al.
Real-world evidence regarding biologic therapy in geriatric psoriasis is limited, particularly concerning systemic inflammatory burden and infection-related safety. This study evaluates the clinical efficacy of biologic therapy and its impa...
Plasma p-tau217, p-tau181 and Aβ42/40 for Alzheimer's disease diagnosis: ROC accuracy and 18F-florbetapir amyloid PET-CT concordance [0.03%]
血浆p-tau217、p-tau181和Aβ42/40诊断阿尔茨海默病的价值及其与18F-FB-Amyloid PET-CT的一致性研究
Zhengying Jing,Rong Wang,Chunmei Zhao et al.
Zhengying Jing et al.
Early diagnosis of Alzheimer's disease (AD) presents significant challenges. This study assessed the diagnostic utility of seven plasma biomarkers and PET-CT imaging in cognitively healthy individuals (HC), those with mild cognitive impairm...
Tumor microenvironment and key signaling pathways in breast cancer progression and therapy resistance: A review [0.03%]
肿瘤微环境和关键信号通路在乳腺癌进展和治疗抵抗中的作用：综述文章
Rui Li,Yujing Wang,Min Xie
Rui Li
Breast cancer progression is influenced not only by intrinsic tumor alterations but also by reciprocal interactions with the tumor microenvironment (TME), a complex ecosystem comprising fibroblasts, immune and endothelial cells, adipocytes,...
Preoperative GNRI and surgical site infection risk after total joint arthroplasty: A systematic review and meta-analysis [0.03%]
术前GNRI与人工关节置换术后手术部位感染风险的相关性：系统评价和 meta 分析
Mingchang Du,Tiejun Liu,Ye Liu et al.
Mingchang Du et al.
Surgical site infections (SSIs), including periprosthetic joint infections (PJIs), represent significant complications following total joint arthroplasty (TJA). The geriatric nutritional risk index (GNRI) serves as an objective measure of n...
Meta-Analysis
Biomolecules & biomedicine. 2026 Feb 27. DOI:10.17305/bb.2026.13414 2026
Circulating tumor DNA as a prognostic biomarker in metastatic colorectal cancer: Post-hoc analysis of treatment response and survival outcomes in the ALTER-C-002 study [0.03%]
ALTER-C-002研究的回顾性分析：循环肿瘤DNA在转移性结直肠癌预后中的标志物价值及对治疗反应和生存结果的影响
Yue Liu,Jin-Jie He,Sheng Chen et al.
Yue Liu et al.
Circulating tumor DNA (ctDNA) derived from blood samples can serve as a minimally invasive, real-time indicator of tumor burden and treatment response in metastatic colorectal cancer. This study evaluated the association between baseline ct...
Single-cell RNA sequencing identifies M2-like macrophage polarization associated with mesenchymal stem cell treatment in a murine sepsis model [0.03%]
单细胞RNA测序识别出与间充质干细胞治疗相关的极化M2型巨噬细胞创建小鼠内毒素血症模型
Takehiko Oami,Takahisa Hishiya,Seiji Miyauchi et al.
Takehiko Oami et al.
Mesenchymal stem cells (MSCs) have demonstrated therapeutic potential in preclinical models of sepsis, primarily through their immunomodulatory functions. However, the specific mechanistic roles of MSCs in the pathophysiology of sepsis, par...
Salivary and urinary microRNAs as non-invasive biomarkers of minimal residual disease in pediatric acute lymphoblastic leukemia [0.03%]
儿童急性淋巴细胞白血病微小残留病的非侵入性生物标志物：唾液和尿液中的microRNA标志物研究
Alejandra Pando-Caciano,Victoria Godoy-Vila,Sergio Murillo-Vizcarra et al.
Alejandra Pando-Caciano et al.
The measurement of minimal residual disease (MRD) in bone marrow serves as a significant predictor of relapse in acute lymphoblastic leukemia (ALL). MicroRNAs, which are secreted in urine and saliva, typically reflect the cellular state and...
Astaxanthin attenuates bisphenol A-induced testicular toxicity in Wistar rats by reducing apoptosis and fibrosis via Bax/Bcl-2 balance and collagen gene expression [0.03%]
虾青素通过平衡Bax / Bcl-2和胶原蛋白基因表达减少凋亡和纤维化来减轻Wistar大鼠中双酚A诱导的睾丸毒性
Halime Tuba Canbaz,Mehmet Enes Sozen,Ilknur Cinar Ayan et al.
Halime Tuba Canbaz et al.
Bisphenol A (BPA), a synthetic compound widely used in plastic manufacturing, has been shown to cause testicular damage and disrupt spermatogenesis. This study aimed to investigate the potential protective effects of astaxanthin (AST) again...
Olfactory dysfunction and increased systemic immune inflammation index in patients with atrial fibrillation [0.03%]
房颤患者的嗅觉障碍和系统性免疫炎症指数升高之间的关系
Ercan Akşit,Ahmet Köder,Uğur Özkan et al.
Ercan Akşit et al.
Atrial fibrillation (AF) is a common arrhythmia with substantial morbidity and a need for accessible markers that reflect disease burden, while olfactory dysfunction and chronic inflammation may share overlapping vascular and neuroinflammat...
Digoxin attenuates LPS-induced acute lung injury in mice via NF-κB and HIF-1α inhibition [0.03%]
毒毛旋花子苷通过抑制NF-κB和HIF-1α缓解脂多糖所致小鼠急性肺损伤
Abdulaziz M Alzahrani,Mai A Alim A Sattar Ahmad,Wafaa S Ramadan et al.
Abdulaziz M Alzahrani et al.
Acute lung injury (ALI), which can progress to the highly lethal acute respiratory distress syndrome (ARDS), remains a condition with limited pharmacological interventions, highlighting the urgent need for mechanism-informed repurposing str...