KDM3A drives NSCLC proliferation and metastasis via H3K9 demethylation, EMT activation and MMP-9 upregulation [0.03%]
KDM3A通过H3K9去甲基化、上皮间质转化激活和MMP-9上调驱动非小细胞肺癌增殖和转移
Bingqing Shi,Zhe Wang,Lei Xiu et al.
Bingqing Shi et al.
Histone methylation dysregulation is a crucial epigenetic driver of lung carcinogenesis; however, the role of lysine-specific demethylase 3A (KDM3A) in non-small cell lung cancer (NSCLC) remains inadequately understood. In this study, we es...
Fırat Canlıkarakaya,Serhat Ocaklı,İbrahim Doğan et al.
Fırat Canlıkarakaya et al.
Bowel perforation represents a prevalent and life-threatening emergency within general surgical pathology. This study aims to evaluate clinical and biochemical parameters that predict mortality in cases of bowel perforation. A retrospective...
Mitochondrial dysfunction triggers Zbp1-mediated necroptosis and inflammation in acute lung injury [0.03%]
线粒体功能障碍通过Zbp1介导的坏死性凋亡引发急性肺损伤中的炎症反应
Mi Zhou,Yuehan Li,Yinying Ren et al.
Mi Zhou et al.
Acute lung injury (ALI) is driven by dysregulated inflammation, but how mitochondrial damage engages necroptosis in alveolar macrophages remains unclear. We aimed to define the mechanistic link between mitochondrial impairment and Zinc fing...
Adipose-derived MSC extracellular vesicles ameliorate sepsis by reprogramming macrophages via miR-21-5p targeting PELI1 [0.03%]
脂肪来源的间充质干细胞外泌体通过miR-21-5p靶向PELI1重构巨噬细胞从而改善脓毒症
Guannan Zhou,Jieqiong Song,Lizhen Xuan et al.
Guannan Zhou et al.
Sepsis is a common and life-threatening condition encountered in intensive care units (ICUs). Mesenchymal stromal cells (MSCs) and their small extracellular vesicles (EVs) have emerged as promising nanotherapeutics, particularly in the cont...
Multidrug resistance, diagnostic challenges, and treatment gaps in Pandoraea infections: A review [0.03%]
pandoraea 感染的多药耐药性、诊断挑战和治疗缺口：综述
Waiel S Halabi,Sulaiman Bani Abdel-Rahman,Hala Altarawneh et al.
Waiel S Halabi et al.
Pandoraea species are emerging multidrug-resistant pathogens increasingly associated with respiratory tract infections, particularly in cystic fibrosis patients. Despite their growing clinical relevance, these bacteria are underrepresented ...
Mitochondrial dysfunction, reactive oxygen species, and diabetes mellitus - A triangular relationship: A review [0.03%]
线粒体功能障碍、活性氧和糖尿病——一种三角关系：综述
Mia Manojlovic,Sonja Zafirovic,Dragana Tomic Naglic et al.
Mia Manojlovic et al.
Diabetes mellitus (DM) disrupts cellular homeostasis and is characterized by mitochondrial structural and functional impairments similar to those found in other metabolic disorders. Mitochondrial dysfunction (MD) leads to the excessive prod...
Sclerostin antibody promotes alveolar bone regeneration after tooth extraction [0.03%]
抗硬化素抗体促进拔牙后的牙槽骨再生
Erdal Ergünol,Rabia Şemsi,Duygu Dayanır et al.
Erdal Ergünol et al.
Sclerostin is a key inhibitor of the Wnt signaling pathway, functioning by binding to the LRP5/6 receptor. This interaction inhibits beta-catenin expression, resulting in the downregulation of osteogenic markers, which contributes to the pr...
Baozhu Liang,Ming Tang,Junqi Huang et al.
Baozhu Liang et al.
Assessment of insulin resistance is increasingly emphasized in patients with systemic lupus erythematosus (SLE) due to its significant role in predicting kidney injury and cardiovascular risk. Given that sustained inflammation is a hallmark...
Iliac vein stenting outcomes in non-thrombotic and thrombotic diseases: A systematic review and meta-analysis [0.03%]
髂总静脉支架治疗非血栓性和血栓性疾病效果：系统回顾和meta分析
Mingxuan Li,Shunquan Wang,Jianwen Zhao et al.
Mingxuan Li et al.
Iliac vein stenting (IVS) is an endovascular revascularization procedure for iliac venous outflow obstruction. We aimed to synthesize the efficacy and safety of IVS across iliac vein disease phenotypes and follow-up horizons. Following a pr...
Meta-Analysis
Biomolecules & biomedicine. 2025 Oct 15. DOI:10.17305/bb.2025.12777 2025
Braden score at ICU admission predicts 30-day mortality in acute pancreatitis [0.03%]
急性胰腺炎患者ICU入院时的Braden评分可预示30天病死率
Lihong Dong,Hong Wang,Xixiang Yang et al.
Lihong Dong et al.
The Braden score, a bedside assessment tool for evaluating the risk of pressure ulcers and frailty, may identify vulnerabilities pertinent to outcomes in acute pancreatitis (AP). However, its prognostic significance in this context remains ...