Exercise and Diet Studies Among Patients Living with Multiple Myeloma: Current Evidence and Considerations of Patient Preferences [0.03%]
多发性骨髓瘤患者运动和饮食研究：现有证据及患者偏好的考量
Kelsey E Maslana,Grace E Skogerboe,Douglas W Sborov et al.
Kelsey E Maslana et al.
Background: Multiple myeloma (MM) is the second most common blood cancer after leukemia in adults. Despite advancements in treatment that have extended survival, MM remains incurable and the cancer and its treatment resul...
Marcus O Muench,Kristbjorn Orri Gudmundsson
Marcus O Muench
Case Report: Childhood Erythrocytosis due to Hypermanganesemia Caused by Homozygous SLC30A10 Mutation [0.03%]
病例报告：由SLC30A10基因同合子突变引起的高锰血症性儿童红细胞增多症
Tiziana Coppola,Hannah Hughes,Paul Finch et al.
Tiziana Coppola et al.
We present a rare case of erythrocytosis due to a homozygous SLC30A10 mutation, causative of Hypermanganesemia with Dystonia, Polycythemia, and Cirrhosis (HMDPC). The patient presented at 7 years of age with the incidental finding of hemogl...
Metabolic reprogramming of fetal hematopoietic stem and progenitor cells by maternal obesity [0.03%]
母体肥胖对胎儿造血干细胞和祖细胞的代谢重组影响
Oleg Varlamov
Oleg Varlamov
Maternal obesity, often linked to the consumption of a high-fat Western-style diet (WSD), poses significant risks to both maternal and fetal health. This review explores the impact of maternal obesity on fetal hematopoietic stem and progeni...
Xin Gao,Jing Zhang,Owen J Tamplin
Xin Gao
Hematopoietic stem cells (HSCs) undergo a functional decline during aging. The intrinsic characteristics of aged HSCs have been well-described and include a strong myeloid bias, an increase in total number, and a decrease in functionality d...
Exploring extramedullary hematopoiesis: unraveling the hematopoietic microenvironments [0.03%]
探索髓外造血：揭示造血微环境
Guadalupe Rivera-Torruco,Marcus O Muench,Ricardo Valle-Rios
Guadalupe Rivera-Torruco
Hematopoiesis is a process by which all blood cells are formed. The mechanisms controlling it have been studied for decades. Surprisingly, while hematopoietic stem cells are among the most extensively studied stem cell types, the complete u...
Generation, characterization, and use of EKLF(Klf1)/CRE knock-in mice for cell-restricted analyses [0.03%]
生成、鉴定及在细胞特异性分析中应用EKLF(Klf1)/CRE敲入小鼠
Li Xue,Kaustav Mukherjee,Kevin A Kelley et al.
Li Xue et al.
Introduction: EKLF/Klf1 is a tissue-restricted transcription factor that plays a critical role in all aspects of erythropoiesis. Of particular note is its tissue-restricted pattern of expression, a property that could pro...
Development of the sickle Pan-African research consortium registry in Tanzania: opportunity to harness data science for sickle cell disease [0.03%]
坦桑尼亚镰刀型红细胞性疾病泛非洲研究协会注册处的建立：利用数据科学研究镰刀型红细胞疾病的机会
Daniel Kandonga,Raphael Zozimus Sangeda,Upendo Masamu et al.
Daniel Kandonga et al.
Background: Sickle cell disease (SCD) is a severe hereditary form of anemia that contributes between 50% and 80% of under-five mortality in Africa. Eleven thousand babies are born with SCD annually in Tanzania, ranking 4t...
Depletion of tet2 results in age-dependent changes in DNA methylation and gene expression in a zebrafish model of myelodysplastic syndrome [0.03%]
Tet2缺失导致髓系肿瘤小鼠模型中年龄相关的DNA甲基化和基因表达变化
Yaseswini Neelamraju,Evisa Gjini,Sagar Chhangawala et al.
Yaseswini Neelamraju et al.
Introduction: Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and dysplasia. The gene encoding ten-eleven translocation 2 (...