Macrophage variance: investigating how macrophage origin influences responses to soluble and physical cues with immortalized vs. primary cells in 2D and 3D culture [0.03%]
巨噬细胞的差异：利用二维和三维培养中的永生化与原代细胞研究巨噬细胞起源对可溶性和物理刺激反应的影响
Jodi Graf,Kartik Bomb,Michael Trautmann-Rodriguez et al.
Jodi Graf et al.
Macrophages are phagocytic innate immune cells capable of phenotypical switching in response to the local microenvironment. Studies often use either primary macrophages or immortalized cell lines for hypothesis testing, therapeutic assessme...
Amberlyn Simmons,Olivia Mihalek,Heather A Bimonte Nelson et al.
Amberlyn Simmons et al.
Sex as a biological variable has been recognized for decades to be a critical aspect of the drug development process, as differences in drug pharmacology and toxicity in female versus male subjects can drive the success or failure of new th...
Maneesha Sahni,Emily S Day
Maneesha Sahni
Endometriosis is an incurable gynecologic disease characterized by endometrial-like tissue growth outside of the uterine cavity. It affects approximately 10% of reproductive age women, who endure pelvic pain during periods and/or sexual int...
Shreya Nagri,Olivia Rice,Yupeng Chen
Shreya Nagri
The blood-brain barrier (BBB) is a crucial part of brain anatomy as it is a specialized, protective barrier that ensures proper nutrient transport to the brain, ultimately leading to regulating proper brain function. However, it presents a ...
Paulina Wiśniewska,Mohammad Reza Saeb,Sidi A Bencherif
Paulina Wiśniewska
Biomaterials undergo a transformative journey, from their origin as renewable resources to the manufacturing plants where they are processed and stored, until they fulfill their intended therapeutic or diagnostic purposes and become medical...
Development of an alginate-Matrigel hydrogel system to evaluate cancer cell behavior in the stiffness range of the bone marrow [0.03%]
开发藻酸盐-Matrigel水凝胶系统以评估骨髓刚性范围内癌症细胞的行为
Logan A Northcutt,Alyssa M Questell,Julie Rhoades et al.
Logan A Northcutt et al.
Bone metastasis is highly prevalent in breast cancer patients with metastatic disease. These metastatic cells may eventually form osteolytic lesions and affect the integrity of the bone, causing pathological fractures and impairing patient ...
Injectable hydrogel with immobilized BMP-2 mimetic peptide for local bone regeneration [0.03%]
一种用于局部骨再生的携带仿生肽的可注射水凝胶
Kirstene A Gultian,Roshni Gandhi,Kayla DeCesari et al.
Kirstene A Gultian et al.
Osteoporosis is a disease characterized by a decrease in bone mineral density, thereby increasing the risk of sustaining a fragility fracture. Most medical therapies are systemic and do not restore bone in areas of need, leading to undesira...