Nonsteroidal Mineralocorticoid Receptor Antagonists in Heart Failure: Mechanistic Basis, Clinical Evidence, and Therapeutic Integration [0.03%]
心力衰竭中非甾体类矿皮质激素受体拮抗剂的作用机制、临床证据及治疗整合
Rami A Al-Horani,Navneet Goyal
Rami A Al-Horani
The therapeutic landscape for heart failure (HF), particularly in patients with mildly reduced (HFmrEF) and preserved ejection fraction (HFpEF), has historically been characterized by limited effective disease-modifying options. The recent ...
Rami A Al-Horani
Rami A Al-Horani
Cancer metabolism is a cornerstone of tumor biology, characterized by profound alterations in cellular energy production and biosynthetic pathways that drive malignancy. The seminal discovery of the "Warburg effect", the preference of cance...
Sarah Scoles,Sanjay Ganesh,Kaori H Yamada
Sarah Scoles
Background/objectives: Uveal melanoma (UM) is a rare but deadly ocular cancer. This review summarizes the characteristics of uveal melanoma and current therapeutic options for primary uveal melanoma and metastatic uveal m...
Suzetrigine: A Novel Non-Opioid Analgesic for Acute Pain Management-A Review [0.03%]
苏泽曲普胺：一种新型的非阿片类急性镇痛药——综述
Meaghan Jones,Aryanna Demery,Rami A Al-Horani
Meaghan Jones
Suzetrigine represents a groundbreaking advancement in acute pain management as the first FDA-approved selective Nav1.8 inhibitor. This comprehensive review synthesizes data from clinical trials, pharmacological studies, and prescribing inf...
Schlesinger Nailed It! Assessing a Key Primary Pharmacodynamic Property of Phages for Phage Therapy: Virion Encounter Rates with Motionless Bacterial Targets [0.03%]
施莱辛格说对了！评估噬菌体疗法的关键药理动力学性质：噬菌体与静止细菌靶标相遇的频率
Stephen T Abedon
Stephen T Abedon
Bacteriophages (phages) are viruses of bacteria and have been used as antibacterial agents now for over one-hundred years. The primary pharmacodynamics of therapeutic phages can be summed up as follows: phages at a certain concentration can...