Cerebellar motor and non-motor contributions to dystonia pathophysiology and treatment [0.03%]
小脑在肌张力障碍病理生理和治疗中的运动和非运动作用
Linda H Kim,Cheryl Brandenburg,Roy V Sillitoe
Linda H Kim
Dystonia is a complex neurological disorder characterized by sustained or intermittent abnormal movements and/or postures. However, dystonia's non-motor symptoms, particularly the sleep disturbances, are critical yet underexplored concerns ...
Is thalamic deep brain stimulation the right target to improve laryngeal dystonia symptoms? [0.03%]
丘脑深部脑刺激改善喉肌张力障碍症状的疗效评估吗？
Lena C O&#x;Flynn,Michael T Barbe,Shiro Horisawa et al.
Lena C O&#x;Flynn et al.
David A Peterson,Myungjoo Kim,Robert Chen et al.
David A Peterson et al.
Dystonia is increasingly recognized as a disorder of brain networks. This review integrates multimodal evidence from human studies to characterize the network-level pathophysiology of dystonia. Structural MRI studies using voxel-based morph...
Assessing vocal changes through spectral analyses of vocalizations in a cerebellar-specific dystonia mouse model [0.03%]
通过发声的光谱分析评估小脑特异性肌张力不全模型小鼠的声音变化
Austin L Fitzgerald,Jonathan A Coello,Alyssa M Lyon et al.
Austin L Fitzgerald et al.
Vocal impairments are a debilitating but understudied feature of several dystonias, including generalized and early-onset genetic forms. Despite growing recognition that cerebellar dysfunction contributes to dystonic pathophysiology, the ci...
Behavioral signature of trihexyphenidyl in the TOR1A (DYT1) knockin mouse model of dystonia [0.03%]
托考林(DYR1)敲入小鼠模型中苯海索的行为标志研究
Ahmad Abdal Qader,Yuping Donsante,Jeffrey E Markowitz et al.
Ahmad Abdal Qader et al.
Dystonia is a neurological disorder characterized by involuntary repetitive movements and abnormal postures. Animal models have played a pivotal role in studying the pathophysiology of dystonia. However, many genetic models, e.g., the Tor1a...
Validation of a torsinA cerebellar knockdown model of DYT1 dystonia [0.03%]
DYT1肌张力不全的torsinA小脑敲低模型验证
Yuning Liu,Hong Xing,Fumiaki Yokoi et al.
Yuning Liu et al.
Dystonia is a movement disorder characterized by sustained or intermittent muscle contractions causing abnormal, often repetitive, movements, postures, or both. DYT1 dystonia is an early-onset dystonia caused by DYT1/TOR1A gene mutations wi...
Social determinants of health and health-related quality of life in individuals with isolated dystonia [0.03%]
孤立性肌张力不全个体的健康和社会决定因素及与健康相关的生活质量
Caroline Nelson,Christopher D Stephen,Ellen B Penney et al.
Caroline Nelson et al.
Background and objectives: Dystonia is the third most common movement disorder. Motor and non-motor manifestations of dystonia may impact Health Related Quality of Life (HRQoL), with lower HRQoL scores compared to the hea...
Pain localization and response to botulinum toxin in cervical dystonia [0.03%]
颈部肌张力障碍的疼痛定位及肉毒杆菌毒素治疗反应
Alexander S Wang,Hanieh Agharazi,Aetan Parmar et al.
Alexander S Wang et al.
Introduction: Pain is a common symptom of cervical dystonia (CD). The mainstay of treatment of CD is botulinum toxin, which is known to have benefits in relieving pain. We aimed to characterize the locations of pain in pa...
Neurorehabilitation in Dystonia Care: Key Questions of Who Benefits, What Modalities, and When to Intervene [0.03%]
扭转痉挛护理中的神经康复：受益人群、干预模式和介入时机的关键问题
Hikaru Kamo,Koichi Nagaki,Alison R Kraus et al.
Hikaru Kamo et al.
Dystonia causes involuntary, patterned movements and posturing, often leading to disability, pain, and reduced quality-of-life. Despite standard treatments such as botulinum toxin (BoNT) injections, oral medications, and deep brain stimulat...
Pattamon Panyakaew,Aparna Wagle Shukla
Pattamon Panyakaew