A Plant Model of α-Synucleinopathy: Expression of α-Synuclein A53T Variant in Hairy Root Cultures Leads to Proteostatic Stress and Dysregulation of Iron Metabolism [0.03%]
α-突触核蛋白病的植物模型：表达A53T突变型α-突触核蛋白的毛状根培养会导致蛋白质稳态压力和铁代谢失调
Jasmina Kurepa,Kristen A Bruce,Greg A Gerhardt et al.
Jasmina Kurepa et al.
Synucleinopathies, typified by Parkinson's disease (PD), entail the accumulation of α-synuclein (αSyn) aggregates in nerve cells. Various αSyn mutants, including the αSyn A53T variant linked to early-onset PD, increase the propensity fo...
Tissue Microarray Lipidomic Imaging Mass Spectrometry Method: Application to the Study of Alcohol-Related White Matter Neurodegeneration [0.03%]
组织微阵列脂质组成像质量谱方法：应用于酒精相关白质神经变性的研究
Isabel Gameiro-Ros,Lelia Noble,Ming Tong et al.
Isabel Gameiro-Ros et al.
Central nervous system (CNS) white matter pathologies accompany many diseases across the lifespan, yet their biochemical bases, mechanisms, and consequences have remained poorly understood due to the complexity of myelin lipid-based researc...