Application of adipose tissue-derived stem cell therapy with a clinically relevant dose does not significantly affect atherosclerotic plaque characteristics in a streptozotocin-induced hyperglycaemia mouse model [0.03%]
临床相关剂量的脂肪源性干细胞治疗不会显著影响链脲佐菌素诱导的高血糖小鼠模型动脉粥样硬化斑块特征
Amber Korn,Suat Simsek,Mitchell D Fiet et al.
Amber Korn et al.
Aims: Diabetes mellitus (DM) induces increased inflammation of atherosclerotic plaques, resulting in elevated plaque instability. Mesenchymal stem cell (MSC) therapy was shown to decrease plaque size and increase stabilit...
Cardiac-targeted delivery of a novel Drp1 inhibitor for acute cardioprotection [0.03%]
一种新型Drp1抑制剂心脏靶向投递的急性心肌保护作用
Jarmon G Lees,David W Greening,David A Rudd et al.
Jarmon G Lees et al.
Dynamin-related protein 1 (Drp1) is a mitochondrial fission protein and a viable target for cardioprotection against myocardial ischaemia-reperfusion injury. Here, we reported a novel Drp1 inhibitor (DRP1i1), delivered using a cardiac-targe...
P-, E-, and H-cadherins differ in their relationships with coronary stenosis, cardiovascular outcomes, and unplanned recurrent revascularization [0.03%]
P-Cadherin、E-Cadherin和H-Cadherin与冠状动脉狭窄、心血管预后及不明原因的再次血运重建的关系不同
Nadezhda G Gumanova,Dmitry K Vasilyev,Natalya L Bogdanova et al.
Nadezhda G Gumanova et al.
Background and aims: Cadherins are adhesion proteins, and their dysregulation may result in the development of atherosclerosis, plaque rupture, or lesions of the vascular wall. The aim of the present study was to detect t...
Myocardial overexpression of protein phosphatase 2A-B56α improves resistance against ischemia-reperfusion injury [0.03%]
心肌过表达蛋白磷酸酶2A-B56α改善缺血再灌注损伤抵抗能力
Julius R Herting,Anna M Berg,Katarina Hadova et al.
Julius R Herting et al.
Protein phosphatase 2A (PP2A) plays a central role in myocardial ischemia-reperfusion (I/R) injury. Several studies showed a detrimental function of PP2A by using either overexpression models of the catalytic subunit (PP2Ac) or exogenous in...
No cell fate conversion of macrophages to endothelial cells after myocardial infarction [0.03%]
心肌梗死后巨噬细胞不会转分化为内皮细胞
Zhengkai Lu,Lingfang Zhuang,Ruiyan Zhang et al.
Zhengkai Lu et al.
MicroRNA miR-378-3p is a novel regulator of endothelial autophagy and function [0.03%]
microRNA miR-378-3p 是内皮自噬和功能的新调节因子
Shuhan Bu,Jameela J Joseph,Hien C Nguyen et al.
Shuhan Bu et al.
Autophagy is a highly conserved cellular process in which cytoplasmic materials are internalized into an autophagosome that later fuses with a lysosome for their degradation and recycling. MicroRNAs (miRNAs) are integral regulators in vario...
Multi-scale modeling will unravel connections between sarcomeric mutations and cardiomyopathies [0.03%]
多尺度模型将揭示肌小节突变与心肌病之间的联系
Stuart G Campbell,Jeffrey R Moore,Michael J Rynkiewicz et al.
Stuart G Campbell et al.
DEG (differentially expressed gene) or not DEG that is the question: Should we compare between datasets or not? [0.03%]
差异表达基因(DEG)还是不是DEG，这是一个问题：我们是否应该在数据集之间进行比较？
Ashutosh Tomar,Samaneh Ekhteraei-Tousi,H Llewelyn Roderick
Ashutosh Tomar
Davor Pavlovic,Rebekah Gundry
Davor Pavlovic
The selective serotonin reuptake inhibitor paroxetine improves right ventricular systolic function in experimental pulmonary hypertension [0.03%]
选择性5-羟色胺再摄取抑制剂帕罗西汀可改善实验性肺动脉高压右心室收缩功能
Mark T Waddingham,Hirotsugu Tsuchimochi,Takashi Sonobe et al.
Mark T Waddingham et al.
Background: Pulmonary hypertension (PH) often leads to right ventricle (RV) failure, a significant cause of morbidity and mortality. Despite advancements in PH management, progression to RV maladaptation and subsequent fa...