Expression of concern regarding "The effect of moderate intensity aerobic exercise on cardiovascular function, cardiorespiratory fitness and estrogen receptor alpha gene in overweight/obese postmenopausal women: A randomized controlled trial" [0.03%]
关于《中等强度有氧运动对超重和肥胖绝经后女性心血管功能、心肺适能及雌激素受体α基因的影响：一项随机对照试验》的表达关切通知
Cardioprotective strategies in myocardial ischemia-reperfusion injury: Implications for improving clinical translation [0.03%]
心肌缺血再灌注损伤的保护策略——改善临床转化的意义
Chao Tong,Bingying Zhou
Chao Tong
Ischemic heart disease is the most common cause of death and disability globally which is caused by reduced or complete cessation of blood flow to a portion of the myocardium. One of its clinical manifestations is myocardial infarction, whi...
Integrated transcriptomic and regulatory RNA profiling reflects complex pathophysiology and uncovers a conserved gene signature in end stage heart failure [0.03%]
整合转录组和调节RNA分析可反映复杂的心脏生理病理并发现终末期心力衰竭中的保守基因特征
Amit Anand,Julius Punnen,U M Nagamalesh et al.
Amit Anand et al.
Background: Heart failure (HF) is a complex syndrome. Despite availability of multiple treatment options, the mortality remains high and the quality of life poor. Better understanding of the underlying pathophysiological ...
Association of LEF1-AS1 with cardiovascular and neurological complications of COVID-19 [0.03%]
LEF1-AS1与COVID-19心血管和神经并发症的关系
Mélanie Vausort,Andrew I Lumley,Hassina Boubakeur et al.
Mélanie Vausort et al.
A significant proportion of COVID-19 patients develop long-term complications, particularly cardiovascular and neurological issues. Even though risk factors for developing complications after COVID-19 have been identified, a biomarker to pr...
Rostafuroxin, the inhibitor of endogenous ouabain, ameliorates chronic undernutrition-induced hypertension, stroke volume, cardiac output, left-ventricular fibrosis and alterations in Na+-transporting ATPases in rats [0.03%]
罗司夫定改善内源性哇巴因诱导的慢性营养不良大鼠高血压、每搏输出量、心排血量、左室纤维化和钠离子转运ATP酶改变
Amaury Pereira-Acácio,João P M Veloso-Santos,Camile O Silva-Rodrigues et al.
Amaury Pereira-Acácio et al.
Our aim has been to investigate the effect of Rostafuroxin, an inhibitor of endogenous cardiotonic steroids (EO/CTS), on cardiac structure and function and cardiac Na+ transport in undernourished hypertensive Wistar rats, and to determine w...
Gemfibrozil mitigates caspase-11-driven myocardial pyroptosis in ischemia/reperfusion injury in mice [0.03%]
吉非罗齐减轻缺血/再灌注损伤小鼠的caspase-11介导的心肌焦亡
Tetsuro Marunouchi,Mayu Kyono,Naoko Kikuchi et al.
Tetsuro Marunouchi et al.
The size of the infarct area following acute myocardial infarction (AMI) is a critical prognostic factor. Caspase-11-dependent pyroptosis has been implicated as a key mechanism driving cardiomyocyte death after AMI. However, no therapeutic ...
Innovations in heart failure management: The role of cutting-edge biomarkers and multi-omics integration [0.03%]
心力衰竭管理的创新：尖端生物标志物和多组学整合的作用
Jose Mesquita Bastos,Beatriz Colaço,Rui Baptista et al.
Jose Mesquita Bastos et al.
Heart failure (HF) remains a major cause of morbidity and mortality worldwide and represents a major challenge for diagnosis, prognosis and treatment due to its heterogeneity. Traditional biomarkers such as BNP and NT-proBNP are valuable bu...
Loss of Snord116 protects cardiomyocyte kinetics during ischemic stress [0.03%]
缺血应激过程中Snord116的丢失可保护心肌细胞的动力学特性
Lucy E Pilcher,Emmaleigh Hancock,Akshay Neeli et al.
Lucy E Pilcher et al.
Loss of Snord116, a non-coding RNA, causes Prader Willi Syndrome (PWS), a complex disorder with circadian, metabolic, neurologic, and cardiovascular phenotypes. The Snord116 paternal knockout (Snord116p-) mouse, a model of PWS, demonstrated...
ADAMTS7, a target in atherosclerosis, cooperates with its homolog ADAMTS12 to protect against myxomatous valve degeneration [0.03%]
ADAMTS7，动脉粥样硬化的一个靶点，与其同源物ADAMTS12共同作用以防止瓣膜病变糜烂
Timothy J Mead,Sumit Bhutada,Niccolò Peruzzi et al.
Timothy J Mead et al.
The physiological roles of the metalloprotease-proteoglycan ADAMTS7, a drug target in atherosclerosis and vascular restenosis, and its homolog ADAMTS12, are undefined in the cardiovascular system. The objective of the present work was to in...
IFNγ activates an immune-like regulatory network in the cardiac vascular endothelium [0.03%]
IFNγ激活心脏血管内皮中的类似免疫调节网络
Timothy D Arthur,Isaac N Joshua,Jennifer P Nguyen et al.
Timothy D Arthur et al.
The regulatory mechanisms underlying the response to pro-inflammatory cytokines in cardiac diseases are poorly understood. Here, we use iPSC-derived cardiovascular progenitor cells (CVPCs) to model the response to interferon gamma (IFNγ) i...