Gemfibrozil mitigates caspase-11-driven myocardial pyroptosis in ischemia/reperfusion injury in mice [0.03%]
吉非罗齐减轻缺血/再灌注损伤小鼠的caspase-11介导的心肌焦亡
Tetsuro Marunouchi,Mayu Kyono,Naoko Kikuchi et al.
Tetsuro Marunouchi et al.
The size of the infarct area following acute myocardial infarction (AMI) is a critical prognostic factor. Caspase-11-dependent pyroptosis has been implicated as a key mechanism driving cardiomyocyte death after AMI. However, no therapeutic ...
Innovations in heart failure management: The role of cutting-edge biomarkers and multi-omics integration [0.03%]
心力衰竭管理的创新：尖端生物标志物和多组学整合的作用
Jose Mesquita Bastos,Beatriz Colaço,Rui Baptista et al.
Jose Mesquita Bastos et al.
Heart failure (HF) remains a major cause of morbidity and mortality worldwide and represents a major challenge for diagnosis, prognosis and treatment due to its heterogeneity. Traditional biomarkers such as BNP and NT-proBNP are valuable bu...
Loss of Snord116 protects cardiomyocyte kinetics during ischemic stress [0.03%]
缺血应激过程中Snord116的丢失可保护心肌细胞的动力学特性
Lucy E Pilcher,Emmaleigh Hancock,Akshay Neeli et al.
Lucy E Pilcher et al.
Loss of Snord116, a non-coding RNA, causes Prader Willi Syndrome (PWS), a complex disorder with circadian, metabolic, neurologic, and cardiovascular phenotypes. The Snord116 paternal knockout (Snord116p-) mouse, a model of PWS, demonstrated...
ADAMTS7, a target in atherosclerosis, cooperates with its homolog ADAMTS12 to protect against myxomatous valve degeneration [0.03%]
ADAMTS7，动脉粥样硬化的一个靶点，与其同源物ADAMTS12共同作用以防止瓣膜病变糜烂
Timothy J Mead,Sumit Bhutada,Niccolò Peruzzi et al.
Timothy J Mead et al.
The physiological roles of the metalloprotease-proteoglycan ADAMTS7, a drug target in atherosclerosis and vascular restenosis, and its homolog ADAMTS12, are undefined in the cardiovascular system. The objective of the present work was to in...
IFNγ activates an immune-like regulatory network in the cardiac vascular endothelium [0.03%]
IFNγ激活心脏血管内皮中的类似免疫调节网络
Timothy D Arthur,Isaac N Joshua,Jennifer P Nguyen et al.
Timothy D Arthur et al.
The regulatory mechanisms underlying the response to pro-inflammatory cytokines in cardiac diseases are poorly understood. Here, we use iPSC-derived cardiovascular progenitor cells (CVPCs) to model the response to interferon gamma (IFNγ) i...
Qifang Wu,Christine Gille,Florian Maderspacher et al.
Qifang Wu et al.
Thrombosis and thromboembolism are serious clinical complications of cardiovascular diseases and are among the leading causes of mortality worldwide. Dysregulation of the renin-angiotensin system is associated with an increased incidence of...
In-depth proteomic profiling identifies potentiation of the LPS response by 7-ketocholesterol [0.03%]
深入蛋白质谱分析揭示了7-酮胆固醇对LPS反应的增强作用
Iain R Phair,Magdalena Sovakova,Noor Alqurashi et al.
Iain R Phair et al.
In patients with stable coronary artery disease, plasma levels of 7-ketocholesterol (7-KC), found at high levels in atherosclerotic lesions, predict risk of incident heart failure dose dependently, potentially contributing to disease aetiol...
Circulating levels of miR-20b-5p are associated with survival in cardiogenic shock [0.03%]
循环miR-20b-5p水平与心源性休克患者生存率的关系
Tuomas Mäntylä,Chunguang Wang,Mikko Hänninen et al.
Tuomas Mäntylä et al.
Cardiogenic shock (CS) is a medical emergency with high in-hospital mortality. New biomarkers are needed to identify patients at a greater risk of adverse outcomes. This study aimed to investigate the prognostic potential of microRNAs (miRN...
Deep plasma and tissue proteome profiling of knockout mice reveals pathways associated with Svep1 deficiency [0.03%]
深度血浆和组织蛋白质组谱分析敲除小鼠发现与Svep1缺陷相关通路
Colleen B Maxwell,Nikita Bhakta,Matthew J Denniff et al.
Colleen B Maxwell et al.
Despite strong causal associations with cardiovascular and metabolic disorders including coronary artery disease, hypertension, and type 2 diabetes, as well as a range of other diseases, the exact function of the protein SVEP1 remains large...
Cardiac growth patterns and metabolism before and after birth in swine: Role of miR in proliferation, hypertrophy and metabolism [0.03%]
猪出生前和出生后的心脏生长模式及代谢情况及其增殖、肥大和代谢中miR的作用规律
Catherine G Dimasi,Jack R T Darby,Stacey L Holman et al.
Catherine G Dimasi et al.
The adult mammalian heart is unable to undergo cardiac repair, limiting potential treatment options after cardiac damage. However, the fetal heart is capable of cardiac repair. In preparation for birth, cardiomyocytes (CMs) undergo major ma...