Structural and functional characterization of the cardiac mitochondria-associated reticular membranes in the ob/ob mouse model [0.03%]
肥胖型小鼠心脏线粒体相关内质网膜的结构和功能表征
Hala Guedouari,Maya Dia,Juliette Geoffray et al.
Hala Guedouari et al.
Type 2 diabetes (T2D) and obesity strongly lead to diabetic cardiomyopathy (DCM). The involvement of mitochondria-associated reticular membranes (MAMs), a signaling hub in the cardiomyocyte, starts to be demonstrated in T2D-related metaboli...
Glyoxal is a superior fixative to formaldehyde in promoting antigenicity and structural integrity in murine cardiac tissues [0.03%]
甘loxal在促进小鼠心脏组织抗原性和结构完整性方面优于甲醛
Allen C T Teng,Dev Mehangrey,Ava Vandenbelt et al.
Allen C T Teng et al.
Background: Immunofluorescence (IF) is an essential technique for evaluating histological and biochemical changes in tissue specimens. A critical step in IF is sample fixation, typically achieved using formaldehyde-based ...
PP2A-B56α is a key determinant of cardiac protein phosphorylation and functional responses to β-adrenergic signalling [0.03%]
PP2A-B56α是心脏蛋白磷酸化修饰及β肾上腺素能信号转导功能反应的关键决定因子
Alican Güran,Yanlong Ji,Pan Fang et al.
Alican Güran et al.
B56α is a protein phosphatase 2 A (PP2A) regulatory subunit which modulates the heart's inotropic response to acute β-adrenergic receptor (β-AR) stimulation, although knowledge of the underlying molecular mechanisms is limited. In this s...
Performance horses as a model for exercise-associated cardiac arrhythmias and sudden cardiac death [0.03%]
以赛马作为运动相关心律失常和猝死的动物模型
Amanda Avison,Peter W Physick-Sheard,W Glen Pyle
Amanda Avison
This paper reviews the myocardial substrate of horses relative to that of humans and discusses the utility of performance horses as a model of exercise-associated cardiac arrhythmias and sudden cardiac death in athletes. The coronary circul...
Independent and synergistic roles of MEK-ERK1/2 and PKC pathways in regulating functional changes in vascular tissue following flow cessation [0.03%]
MEK-ERK1/2和PKC信号通路在调节血流阻断引起的血管功能变化中的独立及协同作用
Spyridoula Kazantzi,Lars Edvinsson,Kristian Agmund Haanes
Spyridoula Kazantzi
Background: The MEK-ERK1/2 and PKC pathways play critical roles in regulating functional changes in tissues, but their interplay remains poorly understood. The vasculature provides an ideal model to study these pathways, ...
SGLT2 inhibitor upregulates myocardial genes for oxidative phosphorylation and fatty acid metabolism in Gαq-mice [0.03%]
SGLT2抑制剂可上调Gαq转基因小鼠心肌氧化磷酸化及脂肪酸代谢相关基因表达
Jordan M Chambers,Dominique Croteau,David R Pimentel et al.
Jordan M Chambers et al.
Background: Mitochondrial dysfunction with decreased ATP production and increased release of reactive oxygen species (ROS) is a hallmark of the failing heart. Although SGLT2 inhibitors have been shown to improve myocardia...
Right ventricle remodelling: from in vitro to in vivo and from simple to complex models [0.03%]
右心室重构：从体外到体内以及从简单到复杂的模型
Paula A da Costa Martins,Martina Calore,Jordy M M Kocken
Paula A da Costa Martins
Right ventricle failure (RVF) is a debilitating disease with no cure available. While much is known about the failing left ventricle (LV), many mechanisms and signalling pathways of remodelling are different between the two ventricles. Over...
Fang Meng,Maxwell Kwok,Yen Chin Hui et al.
Fang Meng et al.
Human induced Pluripotent Stem Cell-derived cardiomyocytes (hiPSC-CMs) are increasingly used to identify potential factors capable of inducing endogenous cardiomyocyte proliferation to regenerate the injured heart. L-type calcium channel bl...
Targeting the CD39/CD73 pathway: New insights into cardiac fibrosis and inflammation in female cardiac surgery patients [0.03%]
靶向CD39/CD73通路：女性心脏手术患者心肌纤维化和炎症的新认识
Eitezaz Mahmood,Mark Robitaille,Yifan Bu et al.
Eitezaz Mahmood et al.
Women undergoing cardiac surgery suffer from worse outcomes than their male counterparts. The reasons for this disparity are multifactorial, but the loss of the protective effects of estrogen likely plays a role. Estrogen acts on the CD39/C...
Electrophysiological comparison of left versus right stellate ganglia neurons [0.03%]
左侧与右侧星状神经节神经元的电生理学比较研究
Arie O Verkerk,Carol Ann Remme,Molly O&#x;Reilly
Arie O Verkerk
Background: The stellate ganglia of the peripheral autonomic nervous system innervate the heart and continuously fine-tune cardiac function to meet physiological demands. The right stellate ganglion (RSG) predominantly in...