Characterization of human living myocardial slices culture-induced adaptations: a translational perspective [0.03%]
人源化心肌切片适应性的特征分析：转化医学视角
Jort S A van der Geest,Ernest Diez Benavente,Willem B van Ham et al.
Jort S A van der Geest et al.
Heart failure involves complex pathophysiological processes, best studied in multicellular human cardiac tissues that reflect the native cellular composition and microenvironment. However, maintaining primary cells and tissues in culture fo...
Is boosting OXPHOS/FAO gene pathways the final end-mechanism of SGLT2i protection? [0.03%]
SGLT2i保护作用是否是通过增强OXPHOS/FAO通路基因表达所致？
Xin Hu,Coert J Zuurbier
Xin Hu
Davor Pavlovic,Rebekah Gundry
Davor Pavlovic
Sirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling [0.03%]
Sirtuin 4通过增强活性氧介导的促纤维化转录信号促进心力衰竭的发展
Nikole J Byrne,Christoph Koentges,Elisabeth Khan et al.
Nikole J Byrne et al.
Aims: Sirtuin 4 (SIRT4) is a mitochondrially-localized stress-responsive NAD+-dependent deacetylase predominantly regulating energy metabolism and reactive oxygen species (ROS) homeostasis. Overexpression of SIRT4 aggrava...
Ultrastructure analysis of mitochondria, lipid droplet and sarcoplasmic reticulum apposition in human heart failure [0.03%]
心力衰竭患者心肌线粒体、脂滴及肌浆网的结构分析
Nadina R Latchman,Tyler L Stevens,Kenneth C Bedi et al.
Nadina R Latchman et al.
Background: Cardiomyocyte structural remodeling is reported as a causal contributor to heart failure (HF) development and progression. Growing evidence highlights the role of organelle apposition in cardiomyocyte function...
Bo Ye,Lu Xiao,Yuyong Xu et al.
Bo Ye et al.
Canonical WNT signaling plays critical, often opposing roles in heart development and disease, but its context-dependent mechanisms remain unclear. We hypothesized that alternative splicing of Tcf7l2, a key nuclear partner of β-catenin, co...
Differential regulation during development, aging, and disease implies heart cell specific functions of the Mediator Complex [0.03%]
发育、衰老和疾病过程中的调控差异暗示了 mediator 复合物具有心肌细胞特异性功能
Dominic W Kolonay,Chad E Grueter,Kedryn K Baskin
Dominic W Kolonay
Transcription directs the heart's development and adaptation to stress signals, and transcriptional dysregulation contributes to developmental disorders, pathological remodeling and heart failure (HF). Stereotypic changes at the mRNA level ...
Atrial electrical alterations with intact cardiac structure and contractile function in a mouse model of an HCM-linked ACTN2 variant [0.03%]
在与肥厚型心肌病相关的ACTN2突变小鼠模型中，心脏结构和收缩功能保持不变下的心房电学改变
Maya Noureddine,Sophie Broadway-Stringer,Christopher O&#x;Shea et al.
Maya Noureddine et al.
Background: Missense variants of Z-disk protein, alpha-actinin-2 (ACTN2), have been linked to hypertrophic cardiomyopathy (HCM). A novel ACTN2 missense variant, M228T, was identified in family members presenting with HCM ...
Low levels of adropin are associated with acute kidney injury after decongestion in patients with acutely decompensated heart failure [0.03%]
低adropin水平与心力衰竭急性失代偿期利尿去容量化后的急性肾损伤相关
Alexander E Berezin,Tetiana A Berezina,Evgen V Novikov et al.
Alexander E Berezin et al.
Background: Patients with acutely decompensated heart failure (ADHF) demonstrated a high risk of acute kidney injury (AKI) and its transition to acute kidney disease after diuretic therapy to reach euvolemic status. The p...
Perinatal death in pig models of hypertrophic cardiomyopathy carrying sarcomere pathogenic variants [0.03%]
携带肌节致病变异的肥厚型心肌病小鼠模型围产期死亡率升高
Tatiana Flisikowska,Björn Petersen,Giulia Mearini et al.
Tatiana Flisikowska et al.
Hypertrophic cardiomyopathy (HCM) is an autosomal-dominant disease caused by genetic variants in sarcomeric proteins, particularly in myosin binding protein C3 (MYBPC3) and myosin heavy chain 7 (MYH7). Less known is that neonatal forms of H...