SGLT2 inhibitor upregulates myocardial genes for oxidative phosphorylation and fatty acid metabolism in Gαq-mice [0.03%]
SGLT2抑制剂可上调Gαq转基因小鼠心肌氧化磷酸化及脂肪酸代谢相关基因表达
Jordan M Chambers,Dominique Croteau,David R Pimentel et al.
Jordan M Chambers et al.
Background: Mitochondrial dysfunction with decreased ATP production and increased release of reactive oxygen species (ROS) is a hallmark of the failing heart. Although SGLT2 inhibitors have been shown to improve myocardia...
Right ventricle remodelling: from in vitro to in vivo and from simple to complex models [0.03%]
右心室重构：从体外到体内以及从简单到复杂的模型
Paula A da Costa Martins,Martina Calore,Jordy M M Kocken
Paula A da Costa Martins
Right ventricle failure (RVF) is a debilitating disease with no cure available. While much is known about the failing left ventricle (LV), many mechanisms and signalling pathways of remodelling are different between the two ventricles. Over...
Fang Meng,Maxwell Kwok,Yen Chin Hui et al.
Fang Meng et al.
Human induced Pluripotent Stem Cell-derived cardiomyocytes (hiPSC-CMs) are increasingly used to identify potential factors capable of inducing endogenous cardiomyocyte proliferation to regenerate the injured heart. L-type calcium channel bl...
Targeting the CD39/CD73 pathway: New insights into cardiac fibrosis and inflammation in female cardiac surgery patients [0.03%]
靶向CD39/CD73通路：女性心脏手术患者心肌纤维化和炎症的新认识
Eitezaz Mahmood,Mark Robitaille,Yifan Bu et al.
Eitezaz Mahmood et al.
Women undergoing cardiac surgery suffer from worse outcomes than their male counterparts. The reasons for this disparity are multifactorial, but the loss of the protective effects of estrogen likely plays a role. Estrogen acts on the CD39/C...
Electrophysiological comparison of left versus right stellate ganglia neurons [0.03%]
左侧与右侧星状神经节神经元的电生理学比较研究
Arie O Verkerk,Carol Ann Remme,Molly O&#x;Reilly
Arie O Verkerk
Background: The stellate ganglia of the peripheral autonomic nervous system innervate the heart and continuously fine-tune cardiac function to meet physiological demands. The right stellate ganglion (RSG) predominantly in...
Expression of concern regarding "The effect of moderate intensity aerobic exercise on cardiovascular function, cardiorespiratory fitness and estrogen receptor alpha gene in overweight/obese postmenopausal women: A randomized controlled trial" [0.03%]
关于《中等强度有氧运动对超重和肥胖绝经后女性心血管功能、心肺适能及雌激素受体α基因的影响：一项随机对照试验》的表达关切通知
Cardioprotective strategies in myocardial ischemia-reperfusion injury: Implications for improving clinical translation [0.03%]
心肌缺血再灌注损伤的保护策略——改善临床转化的意义
Chao Tong,Bingying Zhou
Chao Tong
Ischemic heart disease is the most common cause of death and disability globally which is caused by reduced or complete cessation of blood flow to a portion of the myocardium. One of its clinical manifestations is myocardial infarction, whi...
Integrated transcriptomic and regulatory RNA profiling reflects complex pathophysiology and uncovers a conserved gene signature in end stage heart failure [0.03%]
整合转录组和调节RNA分析可反映复杂的心脏生理病理并发现终末期心力衰竭中的保守基因特征
Amit Anand,Julius Punnen,U M Nagamalesh et al.
Amit Anand et al.
Background: Heart failure (HF) is a complex syndrome. Despite availability of multiple treatment options, the mortality remains high and the quality of life poor. Better understanding of the underlying pathophysiological ...
Association of LEF1-AS1 with cardiovascular and neurological complications of COVID-19 [0.03%]
LEF1-AS1与COVID-19心血管和神经并发症的关系
Mélanie Vausort,Andrew I Lumley,Hassina Boubakeur et al.
Mélanie Vausort et al.
A significant proportion of COVID-19 patients develop long-term complications, particularly cardiovascular and neurological issues. Even though risk factors for developing complications after COVID-19 have been identified, a biomarker to pr...
Rostafuroxin, the inhibitor of endogenous ouabain, ameliorates chronic undernutrition-induced hypertension, stroke volume, cardiac output, left-ventricular fibrosis and alterations in Na+-transporting ATPases in rats [0.03%]
罗司夫定改善内源性哇巴因诱导的慢性营养不良大鼠高血压、每搏输出量、心排血量、左室纤维化和钠离子转运ATP酶改变
Amaury Pereira-Acácio,João P M Veloso-Santos,Camile O Silva-Rodrigues et al.
Amaury Pereira-Acácio et al.
Our aim has been to investigate the effect of Rostafuroxin, an inhibitor of endogenous cardiotonic steroids (EO/CTS), on cardiac structure and function and cardiac Na+ transport in undernourished hypertensive Wistar rats, and to determine w...