Disruption of ventricular activation by subthreshold delayed afterdepolarizations in RyR2-R420Q catecholaminergic polymorphic ventricular tachycardia [0.03%]
儿茶酚胺多形性室速 RyR2-R420Q 突变小鼠模型中亚阈值迟发后除极诱发心室激活异常
Ewan D Fowler,Salimata L Diakite,Ana M Gomez et al.
Ewan D Fowler et al.
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) carries increased risk of ventricular arrhythmias due to altered Ca2+ regulation associated with mutations in the ryanodine receptor (RyR2). Increas...
Bioinformatics tools for drug repurposing: a tutorial using heart failure as a case study [0.03%]
药物再利用的生物信息学工具教程——以心力衰竭为例研究
Ivo Fonseca,Fábio Trindade,Mário Santos et al.
Ivo Fonseca et al.
Purpose: Drug repurposing is a crucial strategy for researchers worldwide to accelerate drug development and mitigate associated risks and costs. Heart failure (HF) is a major global health problem with high prevalence an...
Genetic deletion or pharmacological inhibition of acetyl-CoA carboxylase 2 enhances fatty acid oxidation and improves cardiac function and survival in the murine ATGL knockout model of severe heart failure [0.03%]
遗传学删除或通过药物抑制乙酰辅酶A羧化酶2可以增强脂肪酸氧化作用，提高心脏ATGL敲除小鼠严重心力衰竭模型的心脏功能和存活率
Mai Usui,Yu Tsurekawa,Tatsuya Ikehara et al.
Mai Usui et al.
Impaired myocardial energetics, including fatty acid oxidation (FAO), is a hallmark feature in the pathophysiology of various disorders. Deficiency of adipose triglyceride lipase (ATGL) results in impaired FAO which leads to severe heart fa...
Blueprint of the distinct metabolite profiles of healthy pig heart chambers [0.03%]
健康猪心脏腔室不同代谢物谱系的蓝图
Retu Haikonen,Topi Meuronen,Ville Koistinen et al.
Retu Haikonen et al.
The heart is one of the most studied organs, with physiological processes and disease research. While it is well-established that significant structural and functional differences exist between the chambers, most studies focus on only a sin...
Pericellular oxygen dynamics in human cardiac fibroblasts and iPSC-cardiomyocytes in high-throughput plates: insights from experiments and modeling [0.03%]
人的心脏成纤维细胞和诱导多能干细胞心肌细胞的周边细胞氧动力学：来自实验与模型的见解
Weizhen Li,David McLeod,Sarah Antonevich et al.
Weizhen Li et al.
Adequate oxygen supply is crucial for proper cellular function. The emergence of high-throughput (HT) expansion of human stem-cell-derived cells and HT in vitro cellular assays for drug testing necessitate monitoring and understanding of th...
Characterization of human living myocardial slices culture-induced adaptations: a translational perspective [0.03%]
人源化心肌切片适应性的特征分析：转化医学视角
Jort S A van der Geest,Ernest Diez Benavente,Willem B van Ham et al.
Jort S A van der Geest et al.
Heart failure involves complex pathophysiological processes, best studied in multicellular human cardiac tissues that reflect the native cellular composition and microenvironment. However, maintaining primary cells and tissues in culture fo...
Is boosting OXPHOS/FAO gene pathways the final end-mechanism of SGLT2i protection? [0.03%]
SGLT2i保护作用是否是通过增强OXPHOS/FAO通路基因表达所致？
Xin Hu,Coert J Zuurbier
Xin Hu
Davor Pavlovic,Rebekah Gundry
Davor Pavlovic
Sirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling [0.03%]
Sirtuin 4通过增强活性氧介导的促纤维化转录信号促进心力衰竭的发展
Nikole J Byrne,Christoph Koentges,Elisabeth Khan et al.
Nikole J Byrne et al.
Aims: Sirtuin 4 (SIRT4) is a mitochondrially-localized stress-responsive NAD+-dependent deacetylase predominantly regulating energy metabolism and reactive oxygen species (ROS) homeostasis. Overexpression of SIRT4 aggrava...
Ultrastructure analysis of mitochondria, lipid droplet and sarcoplasmic reticulum apposition in human heart failure [0.03%]
心力衰竭患者心肌线粒体、脂滴及肌浆网的结构分析
Nadina R Latchman,Tyler L Stevens,Kenneth C Bedi et al.
Nadina R Latchman et al.
Background: Cardiomyocyte structural remodeling is reported as a causal contributor to heart failure (HF) development and progression. Growing evidence highlights the role of organelle apposition in cardiomyocyte function...