Davor Pavlovic,Rebekah Gundry
Davor Pavlovic
Jules C Hancox,Andrew F James
Jules C Hancox
Wnt/β-catenin signaling regulates cardiac Cx43 in a metabolic substrate-dependent manner [0.03%]
Wnt/β-catenin信号通过代谢底物依赖的方式调节心脏Cx43蛋白表达
Omar Kayyem,Ruonan Gu,Ying Xia et al.
Omar Kayyem et al.
Background: Both Nav1.5 and Cx43 are critical for the fast electrical impulse conduction in the myocardium and their reductions create the arrhythmogenic substrate. Wnt/β-catenin signaling is activated in arrhythmogenic ...
Systemic administration of analgesic buprenorphine, but not carprofen, affects cardiomyocyte contractility in rodents [0.03%]
全身给药的止痛剂布苯苯诺菲，而不是卡普罗芬，会影响啮齿动物的心肌细胞收缩力
Inez Duursma,Valentijn Jansen,Nicole Zaat et al.
Inez Duursma et al.
Rodents are often used in cardiac research, where they undergo a wide variety of procedures. To ensure animal welfare, the rodents are often analgesized before, during and/or after a procedure. Contractility measurements in isolated murine ...
Single-cell dynamics reveal a stress-induced decision between hypertrophy and apoptosis in neonatal rat cardiomyocytes [0.03%]
单细胞动态分析揭示新生大鼠心肌细胞应激反应中肥大与凋亡的决定过程
Bryan Chun,Lavie Ngo,Jeffrey J Saucerman
Bryan Chun
Cardiomyocyte hypertrophy and apoptosis underlie cardiomyopathies and heart failure. While previous studies have reported both hypertrophy and apoptosis at the population level, how individual cells commit to these distinct analog and digit...
Ac-SDKP and eplerenone confer additive cardioprotection against angiotensin II-induced cardiac injury in C57BL/6J mice [0.03%]
阿魏酸-sod衍生的卡宾化合物和依普利酮对血管紧张素Ⅱ致C57BL/6J小鼠心肌损伤的协同保护作用研究
Suhail Hamid,Sarah Sarkar,Hongmei Peng et al.
Suhail Hamid et al.
Eplerenone, a mineralocorticoid receptor antagonist, is an anti-hypertensive and cardioprotective drug. We showed that N-Acetyl-Seryl-Aspartyl-Proline (Ac-SDKP) exerts beneficial effects on the heart. Whether Ac-SDKP provides additional car...
Med13 and Med13L: Critical redundant players in basal cardiac function and gene expression [0.03%]
Med13和Med13L：心脏基本功能和基因表达中的关键冗余调控因子
Kayla M Henry,Richard N Gardner,Alexis M Oppman et al.
Kayla M Henry et al.
Background: Previous studies have linked mutations in the Mediator complex, specifically Mediator 13 (Med13) and Mediator 13-like (Med13L), with both congenital heart defects and cardiovascular diseases. Med13 and Med13L ...
Sex-specific human electromechanical multiscale in-silico models for virtual therapy evaluation [0.03%]
性别特异性的人体机电多尺度仿真模型用于虚拟疗法评估
Maxx Holmes,Zhinuo Jenny Wang,Ruben Doste et al.
Maxx Holmes et al.
Background: Women are under-represented in cardiovascular research, leading to poorer outcomes. Investigating sex-differences in electromechanical function is essential for improving therapy evaluation. This study present...
Generation and evaluation of a novel PI3K-targeting gene therapy in the failing mouse heart and healthy sheep heart [0.03%]
一种新型PI3K靶向基因疗法在衰竭的小鼠心脏和健康羊心上的生成与评估
Sebastian Bass-Stringer,Daniel G Donner,Clive N May et al.
Sebastian Bass-Stringer et al.
Heart failure (HF) remains a clinical challenge with cardiac dysfunction typically progressing even with treatment, and heart transplants only available to small numbers. We previously identified phosphoinositide 3-kinase (PI3K, p110α) as ...
Current status and challenges of multi-omics research using animal models of atherosclerosis [0.03%]
动脉粥样硬化动物模型多组学研究的现状与挑战
Tijana Mitić,Adriana Georgescu,Nicoleta Alexandru-Moise et al.
Tijana Mitić et al.
Atherosclerosis is an underlying cause of cardiovascular diseases (CVD) which account for most deaths worldwide. Use of diverse preclinical models of atherosclerosis has been implemental in understanding the underlying mechanisms, the impli...