Ac-SDKP and eplerenone confer additive cardioprotection against angiotensin II-induced cardiac injury in C57BL/6J mice [0.03%]
阿魏酸-sod衍生的卡宾化合物和依普利酮对血管紧张素Ⅱ致C57BL/6J小鼠心肌损伤的协同保护作用研究
Suhail Hamid,Sarah Sarkar,Hongmei Peng et al.
Suhail Hamid et al.
Eplerenone, a mineralocorticoid receptor antagonist, is an anti-hypertensive and cardioprotective drug. We showed that N-Acetyl-Seryl-Aspartyl-Proline (Ac-SDKP) exerts beneficial effects on the heart. Whether Ac-SDKP provides additional car...
Med13 and Med13L: Critical redundant players in basal cardiac function and gene expression [0.03%]
Med13和Med13L：心脏基本功能和基因表达中的关键冗余调控因子
Kayla M Henry,Richard N Gardner,Alexis M Oppman et al.
Kayla M Henry et al.
Background: Previous studies have linked mutations in the Mediator complex, specifically Mediator 13 (Med13) and Mediator 13-like (Med13L), with both congenital heart defects and cardiovascular diseases. Med13 and Med13L ...
Sex-specific human electromechanical multiscale in-silico models for virtual therapy evaluation [0.03%]
性别特异性的人体机电多尺度仿真模型用于虚拟疗法评估
Maxx Holmes,Zhinuo Jenny Wang,Ruben Doste et al.
Maxx Holmes et al.
Background: Women are under-represented in cardiovascular research, leading to poorer outcomes. Investigating sex-differences in electromechanical function is essential for improving therapy evaluation. This study present...
Generation and evaluation of a novel PI3K-targeting gene therapy in the failing mouse heart and healthy sheep heart [0.03%]
一种新型PI3K靶向基因疗法在衰竭的小鼠心脏和健康羊心上的生成与评估
Sebastian Bass-Stringer,Daniel G Donner,Clive N May et al.
Sebastian Bass-Stringer et al.
Heart failure (HF) remains a clinical challenge with cardiac dysfunction typically progressing even with treatment, and heart transplants only available to small numbers. We previously identified phosphoinositide 3-kinase (PI3K, p110α) as ...
Current status and challenges of multi-omics research using animal models of atherosclerosis [0.03%]
动脉粥样硬化动物模型多组学研究的现状与挑战
Tijana Mitić,Adriana Georgescu,Nicoleta Alexandru-Moise et al.
Tijana Mitić et al.
Atherosclerosis is an underlying cause of cardiovascular diseases (CVD) which account for most deaths worldwide. Use of diverse preclinical models of atherosclerosis has been implemental in understanding the underlying mechanisms, the impli...
MitoQ Protects Against Oxidative Stress-Induced Mitochondrial Dysregulation in Human Cardiomyocytes [0.03%]
MitoQ通过抑制氧化应激诱导的线粒体功能障碍保护人类心肌细胞
Alex M Parker,Jarmon G Lees,Mitchel Tate et al.
Alex M Parker et al.
The overproduction of reactive oxygen species (ROS) and mitochondrial dysregulation are regarded as key mechanisms in the progression of cardiac remodelling in cardiometabolic diseases including heart failure. Conventional treatments are of...
Myocardial damage post short-term self-administration cocaine usage in rat [0.03%]
短期自用可卡因引起的心肌损伤的动物实验研究
Muhammad Zubair Saleem,Tian Liu,Ningjing Song et al.
Muhammad Zubair Saleem et al.
Cocaine abuse remains a significant risk with profound adverse impact on cardiovascular health. While long-term cocaine addiction-induced cardiotoxicity is well-documented, the underlying mechanism and the molecular effects of short-term re...
Cardiology's best friend: Using naturally occurring disease in dogs to understand heart disease in humans [0.03%]
cardiology的最佳伙伴：利用狗的自然发病了解人类的心脏病
W Glen Pyle
W Glen Pyle
Heart diseases are a leading cause of death globally. Laboratory and preclinical animal models of disease have been critical in advancing our understanding of the mechanisms of pathology, creating diagnostic tools, and developing therapeuti...
Semaphorin 3F is elevated in serum of heart failure patients and inhibits cardiac angiogenesis via the VEGF/Akt/eNOS pathway [0.03%]
血清半导体素3F在心力衰竭患者中升高并通过VEGF/Akt/eNOS途径抑制心脏血管生成
Diana Petrova,Miki Weberbauer,Stephanie Reichert et al.
Diana Petrova et al.
Left ventricular (LV) remodeling in heart failure (HF) is associated with vascular rarefaction and impaired angiogenesis. The inhibition of vascular endothelial growth factor (VEGF)-mediated angiogenesis is a key feature in the pathophysiol...
Combined genome and transcriptome analysis identifies molecular signatures of aortic disease in patients with Marfan syndrome [0.03%]
联合基因组和转录组分析确定了马方综合征患者主动脉疾病的分子特征
Katherine B Stanley,Alexa V Mederos,Ethan H Barksdale et al.
Katherine B Stanley et al.
Introduction: Transcriptional dysregulation in patients with Marfan syndrome (MFS) is complex and not well-defined. There are likely patient-specific and general mechanisms in the aortic pathology. In this study, we combi...