Cancer-driven cytokine immunomodulation ameliorates cardiac function and suppresses fibrosis [0.03%]
癌症驱动的细胞因子免疫调节改善心脏功能并抑制纤维化
Laris Achlaug,Lama Awwad,Irina Langier Goncalves et al.
Laris Achlaug et al.
Heart failure remains a leading cause of morbidity and mortality worldwide, with limited progress in the development of novel therapies. It has been demonstrated that tumor growth improves cardiac function and reduces myocardial fibrosis in...
Coxsackie and adenovirus receptor is a novel regulator of inflammatory response in endotoxin-induced failing heart [0.03%]
柯萨奇病毒和腺病毒受体是内毒素诱导的心力衰竭中炎性反应的新调控因子
Reo Matsumura,Mototsugu Nishii,Haruya Usuku et al.
Reo Matsumura et al.
The regulatory mechanisms for inflammatory response in the heart to endotoxin, which causes severe cardiac dysfunction, are not fully understood. We hypothesized the involvement of coxsackie and adenovirus receptor (CXADR), which can promot...
Rab10 plays a protective role in the development of pathological cardiac hypertrophy [0.03%]
Rab10在病理性心脏肥厚发生发展中的保护作用研究
Fang Xu,Min Wu,Yihan Wang et al.
Fang Xu et al.
Prolonged cardiac hypertrophy is a main risk factor for heart failure (HF). During cardiac hypertrophy remodelling, there is an increase in protein synthesis, as well as the trafficking and localization of proteins to their functional sites...
Signaling pathway alterations in hearts of a porcine model harboring a β-myosin heavy chain (MYH7-R403Q) gene variant [0.03%]
携带β-肌球蛋白重链(MYH7-R403Q)基因变异的猪模型心脏信号通路改变
Chad M Warren,David M Ryba,Gail E Geist et al.
Chad M Warren et al.
The disease-causing myosin variant (MYH7-403Q) is linked to hypertrophic cardiomyopathy (HCM). We carried out a research study of signaling pathways in heart samples from control wild-type (WT) GE Yucatán mini-pigs and their littermates ha...
YAP/TAZ deletion in vascular smooth muscle cells mirrors atherosclerosis-associated transcriptional programs [0.03%]
血管平滑肌细胞中YAP / TAZ的缺失可模拟动脉粥样硬化相关的转录程序
Fatima Daoud,Johan Holmberg,Hanna Winter et al.
Fatima Daoud et al.
The transcriptional co-activators YAP (YAP1) and TAZ (WWTR1) are central regulators of vascular smooth muscle cell (VSMC) phenotype and vascular homeostasis. This study investigates the consequences of VSMC-specific YAP/TAZ deletion and its...
Deletion of CHOP in beta cell protects mice from cardiovascular complications in type 2 diabetes: evidence from a pre-clinical mouse model [0.03%]
在2型糖尿病小鼠模型中CHOP基因缺失使β细胞免受心血管并发症损害：来自临床前小鼠模型的证据
Balaji Srinivas,Kiran Alluri,Nour-Eddine Rhaleb et al.
Balaji Srinivas et al.
Introduction: Cardiovascular complications are the leading cause of morbidity and mortality in patients with type 2 diabetes (T2D), which is recognized as a major independent risk factor for coronary artery disease, strok...
Age, sex, and vessel region affect the vasomotor function and gene expression signature of the aorta in mice [0.03%]
年龄、性别和血管区域影响小鼠主动脉的血管运动功能和基因表达特征
Lars Saemann,Lotta Hartrumpf,Adrian-Iustin Georgevici et al.
Lars Saemann et al.
Introduction: Vascular aging is associated with endothelial dysfunction, changes in vascular elasticity or stiffness, and the prevalence of cardiovascular diseases. Aging differs by sex. The effects of age, sex, and vesse...
Nanoscale architecture and dynamics of CaV1.3 channel clusters in cardiac myocytes revealed by single channel nanoscopy [0.03%]
心脏肌细胞中CaV1.3通道簇的纳米级结构和动力学机制
Niko Schwenzer,Roman Tsukanov,Tobias Kohl et al.
Niko Schwenzer et al.
The clustering of L-type calcium channels (LTCC) for functional regulation of intracellular calcium signaling remains poorly understood. Here we applied super-resolution imaging to study CaV1.3 channel clusters in human iPSC-derived atrial ...
Quantification of morphological, functional, and biochemical features of H9c2 rat cardiomyoblast retinoic acid differentiation [0.03%]
H9c2大鼠心肌细胞分化过程中形态学、功能和生化特征的量化研究
Nicole S York,Joel E Rivera,Mohammadreza Rahmani Manesh et al.
Nicole S York et al.
Cell culture models enable advancement in our understanding of heart development and heart disease. The H9c2 rat ventricular cardiomyoblast cell line can be differentiated with retinoic acid and low serum, leading to morphological, molecula...
Cardiac magnetic resonance imaging and cardiac scintigraphy in the diagnosis of cardiac amyloidosis: A meta-analysis of 4866 patients [0.03%]
基于4866例患者的原发性心脏淀粉样变诊断中心血管磁共振与心肌闪烁显像的meta分析
Mahmoud Balata,Abdelrahman M Attia,Mohamed Ibrahim Gbreel et al.
Mahmoud Balata et al.
Introduction: Cardiac amyloidosis (CA) impacts about 20 % of elderly heart failure patients, leading to myocardial dysfunction and life-threatening risks. However, it often remains undetected due to the significant risks ...