Autonomic neuro-cardiac profile of electrical, structural and neuronal remodeling in myocardial infarction-induced heart failure [0.03%]
心肌梗死后心脏重构的自主神经心血管特征分析
Shui Hao Chin,Emily Allen,Kieran E Brack et al.
Shui Hao Chin et al.
Aims: Heart failure is a clinical syndrome typified by abnormal autonomic tone, impaired ventricular function, and increased arrhythmic vulnerability. This study aims to examine electrophysiological, structural and neuron...
Metformin preconditioning protects against myocardial stunning and preserves protein translation in a mouse model of cardiac arrest [0.03%]
双胍保护心脏 Arrest 诱导的心肌抑制和蛋白质合成
Cody A Rutledge,Claudia Lagranha,Takuto Chiba et al.
Cody A Rutledge et al.
Cardiac arrest (CA) causes high mortality due to multi-system organ damage attributable to ischemia-reperfusion injury. Recent work in our group found that among diabetic patients who experienced cardiac arrest, those taking metformin had l...
RNAseq profiling of blood from patients with coronary artery disease: Signature of a T cell imbalance [0.03%]
冠心病患者血液的RNA测序谱型分析——T淋巴细胞失衡的标志
Timothy A McCaffrey,Ian Toma,Zhaoqing Yang et al.
Timothy A McCaffrey et al.
Background: Cardiovascular disease had a global prevalence of 523 million cases and 18.6 million deaths in 2019. The current standard for diagnosing coronary artery disease (CAD) is coronary angiography either by invasive...
Diet modification reverses diastolic dysfunction in rats with heart failure and preserved ejection fraction [0.03%]
饮食改变可逆转心脏功能保存型心力衰竭大鼠的舒张功能障碍
Myung Yoon Kim,Isabelle Pellot,Catherine Bresee et al.
Myung Yoon Kim et al.
Dahl Salt-Sensitive (DSS) rats develop heart failure with preserved ejection fraction (HFpEF) when fed a high-salt (8 % NaCl) diet. Hypertension-induced inflammation and subsequent ventricular fibrosis are believed to underlie the developme...
Evaluation of the DBA/2J mouse as a potential background strain for genetic models of cardiomyopathy [0.03%]
评估DBA/2J小鼠作为心脏肌肉病遗传模型背景系的潜力
Cora C Hart,Young Il Lee,David W Hammers et al.
Cora C Hart et al.
The potential use of the D2.mdx mouse (the mdx mutation on the DBA/2J genetic background) as a preclinical model of the cardiac aspects of Duchenne muscular dystrophy (DMD) has been criticized based on speculation that the DBA/2J genetic ba...
Low expression of the K280N TNNT2 mutation is sufficient to increase basal myofilament activation in human hypertrophy cardiomyopathy [0.03%]
TNNT2(K280N)低表达足以增加人类肥厚型心肌病基础肌丝活化
Vasco Sequeira,Lili Wang,Paul J M Wijnker et al.
Vasco Sequeira et al.
Background: Hypertrophic cardiomyopathy (HCM) is an autosomal dominant genetic disorder with patients typically showing heterozygous inheritance of a pathogenic variant in a gene encoding a contractile protein. Here, we s...
Knockout of ACE-N facilitates improved cardiac function after myocardial infarction [0.03%]
ACE-N基因敲除改善心肌梗死后心脏功能
Hamid Suhail,Hongmei Peng,Jiang Xu et al.
Hamid Suhail et al.
Angiotensin-converting enzyme (ACE) hydrolyzes N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) into inactive fragments through its N-terminal site (ACE-N). We previously showed that Ac-SDKP mediates ACE inhibitors' cardiac effects. Whether ...
Serial measurements of protein and microRNA biomarkers to specify myocardial infarction subtypes [0.03%]
重复测量蛋白和微小核糖核酸生物标志物以确定心肌梗死亚型
Christian Schulte,Bhawana Singh,Konstantinos Theofilatos et al.
Christian Schulte et al.
Background: While cardiac-specific troponin (cTn) allows for rapid diagnosis of acute type 1 myocardial infarction (T1MI), its performance to differentiate acute myocardial injury (AI) or type 2 myocardial infarction (T2M...
(Epi)transcriptomics in cardiovascular and neurological complications of COVID-19 [0.03%]
心血管和神经系统并发症的表观转录组学研究
Amela Jusic,Konstantinos Stellos,Lino Ferreira et al.
Amela Jusic et al.
Although systemic inflammation and pulmonary complications increase the mortality rate in COVID-19, a broad spectrum of cardiovascular and neurological complications can also contribute to significant morbidity and mortality. The molecular ...