Treatment with αvβ3-integrin-specific 29P attenuates pressure-overload induced cardiac remodelling after transverse aortic constriction in mice [0.03%]
αvβ3-整合素特异性配体29P缓解了小鼠主动脉缩窄后的压力过载诱导的心脏重塑
Alexandra Njegić,Lina Laid,Min Zi et al.
Alexandra Njegić et al.
Heart failure remains one of the largest clinical burdens globally, with little to no improvement in the development of disease-eradicating therapeutics. Integrin targeting has been used in the treatment of ocular disease and cancer, but li...
Monitoring mitochondrial calcium in cardiomyocytes during coverslip hypoxia using a fluorescent lifetime indicator [0.03%]
一种荧光寿命指示剂在盖玻片缺氧培养的心肌细胞中监测线粒体钙离子中的应用研究
Yusuf Mastoor,Mikako Harata,Kavisha Silva et al.
Yusuf Mastoor et al.
An increase in mitochondrial calcium via the mitochondrial calcium uniporter (MCU) has been implicated in initiating cell death in the heart during ischemia-reperfusion (I/R) injury. Measurement of calcium during I/R has been challenging du...
Microtubule destabilization with colchicine increases the work output of myocardial slices [0.03%]
秋水仙素诱导微管解聚可增加心肌片的能量代谢产物生成及收缩力
Emmaleigh N Hancock,Bradley M Palmer,Matthew A Caporizzo
Emmaleigh N Hancock
Cardiac microtubules have recently been implicated in mechanical dysfunction during heart failure. However, systemic intolerance and non-cardiac effects of microtubule-depolymerizing compounds have made it challenging to determine the effec...
Unveiling the vulnerability of C57BL/6J female mice to HFpEF and its related complications [0.03%]
揭开C57BL/6J雌性小鼠对HFpEF及其相关并发症易感性的面纱
B Srinivas,K Alluri,H Peng et al.
B Srinivas et al.
Introduction: The impact of female biological sex on the development of heart failure with preserved ejection fraction (HFpEF) and its associated kidney disease and vascular endothelial dysfunction is still controversial....
Angiotensin II induces endothelial dysfunction and vascular remodeling by downregulating TRPV4 channels [0.03%]
血管紧张素II通过降低TRPV4通道的表达来诱导内皮功能障碍和血管重塑
Narendra Babu Kondapalli,Venkatesh Katari,Kesha Dalal et al.
Narendra Babu Kondapalli et al.
Angiotensin II (Ang II) is a potent vasoconstrictor of vascular smooth muscle cells (VSMC) and is implicated in hypertension, but it's role in the regulation of endothelial function is not well known. We and others have previously shown tha...
Effects of canagliflozin on myocardial microvascular density, oxidative stress, and proteomic profile☆ [0.03%]
卡格列净对心肌微血管密度、氧化应激及蛋白质组学谱的影响pływ
Sharif A Sabe,Cynthia M Xu,Mohamed Sabra et al.
Sharif A Sabe et al.
Introduction: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are cardioprotective, and canagliflozin (CANA), an SGLT2i, has been shown to improve perfusion, AMPK signaling, and oxidative stress in chronically ischemic...
Inhibition of miR-199a-3p in a murine hypertrophic cardiomyopathy (HCM) model attenuates fibrotic remodeling [0.03%]
小鼠肥厚型心肌病(HCM)模型中miR-199a-3p的抑制作用减轻纤维化重构
Irina Zalivina,Temo Barwari,Xiaoke Yin et al.
Irina Zalivina et al.
Background: Hypertrophic cardiomyopathy (HCM) is an autosomal dominant genetic disorder, characterized by cardiomyocyte hypertrophy, cardiomyocyte disarray and fibrosis, which has a prevalence of ∼1: 200-500 and predispo...
New synthetic cannabinoids and the potential for cardiac arrhythmia risk [0.03%]
新的合成大麻素和心律失常风险的潜在联系
Jules C Hancox,Caroline S Copeland,Stephen C Harmer et al.
Jules C Hancox et al.
Synthetic cannabinoid receptor agonists (SCRAs) have been associated with QT interval prolongation. Limited preclinical information on SCRA effects on cardiac electrogenesis results from the rapid emergence of new compounds and restricted r...
OptoDyCE-plate as an affordable high throughput imager for all optical cardiac electrophysiology [0.03%]
OptoDyCE-plate作为一项经济实惠的高通量成像技术用于全光学心脏电生理学
Yuli W Heinson,Julie L Han,Emilia Entcheva
Yuli W Heinson
We present a simple low-cost system for comprehensive functional characterization of cardiac function under spontaneous and paced conditions, in standard 96 and 384-well plates. This full-plate actuator/imager, OptoDyCE-plate, uses optogene...
KairoSight-3.0: A validated optical mapping software to characterize cardiac electrophysiology, excitation-contraction coupling, and alternans [0.03%]
KairoSight-3.0：一种表征心脏电生理学、兴奋收缩偶联和交替搏动的光学图谱软件
Kazi T Haq,Anysja Roberts,Fiona Berk et al.
Kazi T Haq et al.
Background: Cardiac optical mapping is an imaging technique that measures fluorescent signals across a cardiac preparation. Dual optical imaging of voltage-sensitive and calcium-sensitive probes allows for simultaneous re...