Low expression of the K280N TNNT2 mutation is sufficient to increase basal myofilament activation in human hypertrophy cardiomyopathy [0.03%]
TNNT2(K280N)低表达足以增加人类肥厚型心肌病基础肌丝活化
Vasco Sequeira,Lili Wang,Paul J M Wijnker et al.
Vasco Sequeira et al.
Background: Hypertrophic cardiomyopathy (HCM) is an autosomal dominant genetic disorder with patients typically showing heterozygous inheritance of a pathogenic variant in a gene encoding a contractile protein. Here, we s...
Knockout of ACE-N facilitates improved cardiac function after myocardial infarction [0.03%]
ACE-N基因敲除改善心肌梗死后心脏功能
Hamid Suhail,Hongmei Peng,Jiang Xu et al.
Hamid Suhail et al.
Angiotensin-converting enzyme (ACE) hydrolyzes N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) into inactive fragments through its N-terminal site (ACE-N). We previously showed that Ac-SDKP mediates ACE inhibitors' cardiac effects. Whether ...
Serial measurements of protein and microRNA biomarkers to specify myocardial infarction subtypes [0.03%]
重复测量蛋白和微小核糖核酸生物标志物以确定心肌梗死亚型
Christian Schulte,Bhawana Singh,Konstantinos Theofilatos et al.
Christian Schulte et al.
Background: While cardiac-specific troponin (cTn) allows for rapid diagnosis of acute type 1 myocardial infarction (T1MI), its performance to differentiate acute myocardial injury (AI) or type 2 myocardial infarction (T2M...
(Epi)transcriptomics in cardiovascular and neurological complications of COVID-19 [0.03%]
心血管和神经系统并发症的表观转录组学研究
Amela Jusic,Konstantinos Stellos,Lino Ferreira et al.
Amela Jusic et al.
Although systemic inflammation and pulmonary complications increase the mortality rate in COVID-19, a broad spectrum of cardiovascular and neurological complications can also contribute to significant morbidity and mortality. The molecular ...