Cardiac overexpression of a mitochondrial SUR2A splice variant impairs cardiac function and worsens myocardial ischemia reperfusion injury in female mice [0.03%]
心肌细胞中线粒体SUR2A剪接变体过表达会损害心脏功能并加重雌性小鼠的心肌缺血再灌注损伤
Allison C Wexler,Holly Dooge,Sarah El-Meanawy et al.
Allison C Wexler et al.
The small splice variant of the sulfonylurea receptor protein isoform 2 A (SUR2A-55) targets mitochondria and enhances mitoKATP activity. In male mice the overexpression of this protein promotes cardioprotection, reducing myocardial injury ...
Allele-specific dysregulation of lipid and energy metabolism in early-stage hypertrophic cardiomyopathy [0.03%]
肥厚性心肌病早期阶段脂质和能量代谢的等位基因特异性失调
Arpana Vaniya,Anja Karlstaedt,Damla Gulkok et al.
Arpana Vaniya et al.
Introduction: Hypertrophic cardiomyopathy (HCM) results from pathogenic variants in sarcomeric protein genes that increase myocyte energy demand and lead to cardiac hypertrophy. However, it is unknown whether a common met...
Sex differences in cardiac mitochondrial respiration and reactive oxygen species production may predispose Scn1a -/+ mice to cardiac arrhythmias and Sudden Unexpected Death in Epilepsy [0.03%]
Scn1a基因突变小鼠心脏线粒体呼吸和活性氧生成的性别差异可能会导致癫痫突然意外死亡及心律失常
Jessa L Aldridge,Emily Davis Alexander,Allison A Franklin et al.
Jessa L Aldridge et al.
Dravet Syndrome (DS) is a pediatric-onset epilepsy with an elevated risk of Sudden Unexpected Death in Epilepsy (SUDEP). Most individuals with DS possess mutations in the voltage-gated sodium channel gene Scn1a, expressed in both the brain ...
Distinct phenotypes induced by acute hypoxia and TGF-β1 in human adult cardiac fibroblasts [0.03%]
急性缺氧和TGF-β1诱导的人成年心脏纤维母细胞表型差异性研究
Natalie N Khalil,Megan L Rexius-Hall,Sean Escopete et al.
Natalie N Khalil et al.
Myocardial infarction (MI) causes hypoxic injury to downstream myocardial tissue, which initiates a wound healing response that replaces injured myocardial tissue with a scar. Wound healing is a complex process that consists of multiple pha...
Comparative analysis of two independent Myh6-Cre transgenic mouse lines [0.03%]
两独立Myh6-Cre转基因小鼠系的比较分析
Amanda Davenport,Chase W Kessinger,Ryan D Pfeiffer et al.
Amanda Davenport et al.
We have previously shown that the Myh6 promoter drives Cre expression in a subset of male germ line cells in three independent Myh6-Cre mouse lines, including two transgenic lines and one knock-in allele. In this study, we further compared ...
Male and female atria exhibit distinct acute electrophysiological responses to sex steroids [0.03%]
性别激素对异性心房急性电生理反应的差异性影响
Simon P Wells,Christopher O&#x;Shea,Sarah Hayes et al.
Simon P Wells et al.
The electrophysiological properties of the hearts of women and men are different. These differences are at least partly mediated by the actions of circulating estrogens and androgens on the cardiomyocytes. Experimentally, much of our unders...
Dietary linoleic acid supplementation fails to rescue established cardiomyopathy in Barth syndrome [0.03%]
饮食中补充亚油酸无法治愈巴尔特氏症引起的进行性心肌病
Siting Zhu,Jing Pang,Anh Nguyen et al.
Siting Zhu et al.
Barth syndrome (BTHS) is a mitochondrial lipid disorder caused by mutations in TAFAZZIN (TAZ), required for cardiolipin (CL) remodeling. Cardiomyopathy is a major clinical feature, with no curative therapy. Linoleic acid (LA) supplementatio...
Roles of cMyBP-C phosphorylation on cardiac contractile dysfunction in db/db mice [0.03%]
cMyBP-C磷酸化对db/db小鼠心脏收缩功能障碍的作用
Darshini A Desai,Akhil Baby,Kalyani Ananthamohan et al.
Darshini A Desai et al.
Type 2 diabetes mellitus (T2DM) is a metabolic disease and comorbidity associated with several conditions, including cardiac dysfunction leading to heart failure with preserved ejection fraction (HFpEF), in turn resulting in T2DM-induced ca...
Dysregulation of cardiac mitochondrial aldehyde dehydrogenase 2: Studies in dogs with chronic heart failure [0.03%]
慢性心力衰竭犬心脏线粒体醛脱氢酶2失调控的研究
Ramesh C Gupta,Vinita Singh-Gupta,Kristina J Szekely et al.
Ramesh C Gupta et al.
Mitochondrial (MITO) dysfunction occurs in the failing heart and contributes to worsening of heart failure (HF). Reduced aldehyde dehydrogenase 2 (ALDH2) in left ventricular (LV) myocardium of diabetic hearts has been implicated in MITO dys...
Olivia Baines,Rina Sha,Siddhanth Jatti et al.
Olivia Baines et al.
KairoSight-3.0 is a recently released Python-based, open-source software for cardiac optical mapping analysis. Addressing challenges in high-resolution electrophysiological data analysis, KairoSight-3.0 facilitates comprehensive studies of ...