Effects of canagliflozin on myocardial microvascular density, oxidative stress, and proteomic profile☆ [0.03%]
卡格列净对心肌微血管密度、氧化应激及蛋白质组学谱的影响pływ
Sharif A Sabe,Cynthia M Xu,Mohamed Sabra et al.
Sharif A Sabe et al.
Introduction: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are cardioprotective, and canagliflozin (CANA), an SGLT2i, has been shown to improve perfusion, AMPK signaling, and oxidative stress in chronically ischemic...
Inhibition of miR-199a-3p in a murine hypertrophic cardiomyopathy (HCM) model attenuates fibrotic remodeling [0.03%]
小鼠肥厚型心肌病(HCM)模型中miR-199a-3p的抑制作用减轻纤维化重构
Irina Zalivina,Temo Barwari,Xiaoke Yin et al.
Irina Zalivina et al.
Background: Hypertrophic cardiomyopathy (HCM) is an autosomal dominant genetic disorder, characterized by cardiomyocyte hypertrophy, cardiomyocyte disarray and fibrosis, which has a prevalence of ∼1: 200-500 and predispo...
New synthetic cannabinoids and the potential for cardiac arrhythmia risk [0.03%]
新的合成大麻素和心律失常风险的潜在联系
Jules C Hancox,Caroline S Copeland,Stephen C Harmer et al.
Jules C Hancox et al.
Synthetic cannabinoid receptor agonists (SCRAs) have been associated with QT interval prolongation. Limited preclinical information on SCRA effects on cardiac electrogenesis results from the rapid emergence of new compounds and restricted r...
OptoDyCE-plate as an affordable high throughput imager for all optical cardiac electrophysiology [0.03%]
OptoDyCE-plate作为一项经济实惠的高通量成像技术用于全光学心脏电生理学
Yuli W Heinson,Julie L Han,Emilia Entcheva
Yuli W Heinson
We present a simple low-cost system for comprehensive functional characterization of cardiac function under spontaneous and paced conditions, in standard 96 and 384-well plates. This full-plate actuator/imager, OptoDyCE-plate, uses optogene...
KairoSight-3.0: A validated optical mapping software to characterize cardiac electrophysiology, excitation-contraction coupling, and alternans [0.03%]
KairoSight-3.0：一种表征心脏电生理学、兴奋收缩偶联和交替搏动的光学图谱软件
Kazi T Haq,Anysja Roberts,Fiona Berk et al.
Kazi T Haq et al.
Background: Cardiac optical mapping is an imaging technique that measures fluorescent signals across a cardiac preparation. Dual optical imaging of voltage-sensitive and calcium-sensitive probes allows for simultaneous re...
Autonomic neuro-cardiac profile of electrical, structural and neuronal remodeling in myocardial infarction-induced heart failure [0.03%]
心肌梗死后心脏重构的自主神经心血管特征分析
Shui Hao Chin,Emily Allen,Kieran E Brack et al.
Shui Hao Chin et al.
Aims: Heart failure is a clinical syndrome typified by abnormal autonomic tone, impaired ventricular function, and increased arrhythmic vulnerability. This study aims to examine electrophysiological, structural and neuron...
Metformin preconditioning protects against myocardial stunning and preserves protein translation in a mouse model of cardiac arrest [0.03%]
双胍保护心脏 Arrest 诱导的心肌抑制和蛋白质合成
Cody A Rutledge,Claudia Lagranha,Takuto Chiba et al.
Cody A Rutledge et al.
Cardiac arrest (CA) causes high mortality due to multi-system organ damage attributable to ischemia-reperfusion injury. Recent work in our group found that among diabetic patients who experienced cardiac arrest, those taking metformin had l...
RNAseq profiling of blood from patients with coronary artery disease: Signature of a T cell imbalance [0.03%]
冠心病患者血液的RNA测序谱型分析——T淋巴细胞失衡的标志
Timothy A McCaffrey,Ian Toma,Zhaoqing Yang et al.
Timothy A McCaffrey et al.
Background: Cardiovascular disease had a global prevalence of 523 million cases and 18.6 million deaths in 2019. The current standard for diagnosing coronary artery disease (CAD) is coronary angiography either by invasive...
Diet modification reverses diastolic dysfunction in rats with heart failure and preserved ejection fraction [0.03%]
饮食改变可逆转心脏功能保存型心力衰竭大鼠的舒张功能障碍
Myung Yoon Kim,Isabelle Pellot,Catherine Bresee et al.
Myung Yoon Kim et al.
Dahl Salt-Sensitive (DSS) rats develop heart failure with preserved ejection fraction (HFpEF) when fed a high-salt (8 % NaCl) diet. Hypertension-induced inflammation and subsequent ventricular fibrosis are believed to underlie the developme...
Evaluation of the DBA/2J mouse as a potential background strain for genetic models of cardiomyopathy [0.03%]
评估DBA/2J小鼠作为心脏肌肉病遗传模型背景系的潜力
Cora C Hart,Young Il Lee,David W Hammers et al.
Cora C Hart et al.
The potential use of the D2.mdx mouse (the mdx mutation on the DBA/2J genetic background) as a preclinical model of the cardiac aspects of Duchenne muscular dystrophy (DMD) has been criticized based on speculation that the DBA/2J genetic ba...