Male and female atria exhibit distinct acute electrophysiological responses to sex steroids [0.03%]
性别激素对异性心房急性电生理反应的差异性影响
Simon P Wells,Christopher O&#x;Shea,Sarah Hayes et al.
Simon P Wells et al.
The electrophysiological properties of the hearts of women and men are different. These differences are at least partly mediated by the actions of circulating estrogens and androgens on the cardiomyocytes. Experimentally, much of our unders...
Dietary linoleic acid supplementation fails to rescue established cardiomyopathy in Barth syndrome [0.03%]
饮食中补充亚油酸无法治愈巴尔特氏症引起的进行性心肌病
Siting Zhu,Jing Pang,Anh Nguyen et al.
Siting Zhu et al.
Barth syndrome (BTHS) is a mitochondrial lipid disorder caused by mutations in TAFAZZIN (TAZ), required for cardiolipin (CL) remodeling. Cardiomyopathy is a major clinical feature, with no curative therapy. Linoleic acid (LA) supplementatio...
Roles of cMyBP-C phosphorylation on cardiac contractile dysfunction in db/db mice [0.03%]
cMyBP-C磷酸化对db/db小鼠心脏收缩功能障碍的作用
Darshini A Desai,Akhil Baby,Kalyani Ananthamohan et al.
Darshini A Desai et al.
Type 2 diabetes mellitus (T2DM) is a metabolic disease and comorbidity associated with several conditions, including cardiac dysfunction leading to heart failure with preserved ejection fraction (HFpEF), in turn resulting in T2DM-induced ca...
Dysregulation of cardiac mitochondrial aldehyde dehydrogenase 2: Studies in dogs with chronic heart failure [0.03%]
慢性心力衰竭犬心脏线粒体醛脱氢酶2失调控的研究
Ramesh C Gupta,Vinita Singh-Gupta,Kristina J Szekely et al.
Ramesh C Gupta et al.
Mitochondrial (MITO) dysfunction occurs in the failing heart and contributes to worsening of heart failure (HF). Reduced aldehyde dehydrogenase 2 (ALDH2) in left ventricular (LV) myocardium of diabetic hearts has been implicated in MITO dys...
Olivia Baines,Rina Sha,Siddhanth Jatti et al.
Olivia Baines et al.
KairoSight-3.0 is a recently released Python-based, open-source software for cardiac optical mapping analysis. Addressing challenges in high-resolution electrophysiological data analysis, KairoSight-3.0 facilitates comprehensive studies of ...
Treatment with αvβ3-integrin-specific 29P attenuates pressure-overload induced cardiac remodelling after transverse aortic constriction in mice [0.03%]
αvβ3-整合素特异性配体29P缓解了小鼠主动脉缩窄后的压力过载诱导的心脏重塑
Alexandra Njegić,Lina Laid,Min Zi et al.
Alexandra Njegić et al.
Heart failure remains one of the largest clinical burdens globally, with little to no improvement in the development of disease-eradicating therapeutics. Integrin targeting has been used in the treatment of ocular disease and cancer, but li...
Monitoring mitochondrial calcium in cardiomyocytes during coverslip hypoxia using a fluorescent lifetime indicator [0.03%]
一种荧光寿命指示剂在盖玻片缺氧培养的心肌细胞中监测线粒体钙离子中的应用研究
Yusuf Mastoor,Mikako Harata,Kavisha Silva et al.
Yusuf Mastoor et al.
An increase in mitochondrial calcium via the mitochondrial calcium uniporter (MCU) has been implicated in initiating cell death in the heart during ischemia-reperfusion (I/R) injury. Measurement of calcium during I/R has been challenging du...
Microtubule destabilization with colchicine increases the work output of myocardial slices [0.03%]
秋水仙素诱导微管解聚可增加心肌片的能量代谢产物生成及收缩力
Emmaleigh N Hancock,Bradley M Palmer,Matthew A Caporizzo
Emmaleigh N Hancock
Cardiac microtubules have recently been implicated in mechanical dysfunction during heart failure. However, systemic intolerance and non-cardiac effects of microtubule-depolymerizing compounds have made it challenging to determine the effec...
Unveiling the vulnerability of C57BL/6J female mice to HFpEF and its related complications [0.03%]
揭开C57BL/6J雌性小鼠对HFpEF及其相关并发症易感性的面纱
B Srinivas,K Alluri,H Peng et al.
B Srinivas et al.
Introduction: The impact of female biological sex on the development of heart failure with preserved ejection fraction (HFpEF) and its associated kidney disease and vascular endothelial dysfunction is still controversial....
Angiotensin II induces endothelial dysfunction and vascular remodeling by downregulating TRPV4 channels [0.03%]
血管紧张素II通过降低TRPV4通道的表达来诱导内皮功能障碍和血管重塑
Narendra Babu Kondapalli,Venkatesh Katari,Kesha Dalal et al.
Narendra Babu Kondapalli et al.
Angiotensin II (Ang II) is a potent vasoconstrictor of vascular smooth muscle cells (VSMC) and is implicated in hypertension, but it's role in the regulation of endothelial function is not well known. We and others have previously shown tha...