Multiomic analyses reveal enriched glycolytic processes in β-myosin heavy chain-expressed cardiomyocytes in early cardiac hypertrophy [0.03%]
多组学分析揭示β-肌球蛋白重链表达心肌细胞在心脏肥大早期富含糖酵解通路
Hsiao-Hui Yeh,Yao-Ming Chang,Yu-Wang Chang et al.
Hsiao-Hui Yeh et al.
Background: Cardiac pressure overload induces cardiac hypertrophy and eventually leads to heart failure. One distinct feature of pathological cardiac hypertrophy is fetal-gene re-expression, but not every cardiomyocyte ex...
Rong Tian,Davor Pavlovic
Rong Tian
90-day mortality risk related to postoperative potassium levels in patients undergoing coronary bypass surgery [0.03%]
冠状动脉旁路移植术后钾水平与90天死亡风险的关系研究
Mikkel Kjeldgaard,Mads Odgaard Mæng,Christian Torp-Pedersen et al.
Mikkel Kjeldgaard et al.
Aims: While electrolyte depletion is known to occur during coronary artery bypass grafting (CABG) with extracorporeal circulation, little is known about the frequency of potassium disturbances following either on- or off-...
Mechano-energetic uncoupling in hypertrophic cardiomyopathy: Pathophysiological mechanisms and therapeutic opportunities [0.03%]
肥厚型心肌病的机械能解耦：病理生理机制和治疗机会
Vasco Sequeira,Mark T Waddingham,Hirotsugu Tsuchimochi et al.
Vasco Sequeira et al.
Hypertrophic cardiomyopathy (HCM) is a frequent inherited form of heart failure. The underlying cause of HCM is generally attributed to mutations in genes that encode for sarcomeric proteins, but the pathogenesis of the disease is also infl...
MicroRNA profiling of the feline left heart identifies chamber-specific expression signatures in health and in advanced hypertrophic cardiomyopathy [0.03%]
微小核糖核酸谱分析猫左心房和左心室在健康状态及晚期肥厚性心肌病时的部位特异性表达特征
Jessica Joshua,Jeff L Caswell,Josep M Monné Rodriguez et al.
Jessica Joshua et al.
Hypertrophic cardiomyopathy (HCM) is a common heart disease in humans and cats, nonetheless, the disease pathogenesis is still poorly understood. MicroRNAs are suspected to be involved in the disease process but the myocardial microRNA expr...
Modeling immune checkpoint inhibitor associated myocarditis in vitro and its therapeutic implications [0.03%]
利用体外模型研究免疫检查点抑制剂相关心肌炎及其治疗意义
Garrett Jensen,Xinjie Wang,Jacob Kuempel et al.
Garrett Jensen et al.
Immune checkpoint inhibitor-associated myocarditis is the most lethal side effect of immune checkpoint blockade. Myocarditis leads to persistently increased mortality and lacks effective treatments. The development of patient-relevant disea...
Nitazene opioids and the heart: Identification of a cardiac ion channel target for illicit nitazene opioids [0.03%]
尼塔津类阿片类物质与心脏的作用：非法尼塔津类阿片类物质的心脏离子通道靶点鉴定
Jules C Hancox,Yibo Wang,Caroline S Copeland et al.
Jules C Hancox et al.
The growing use of nitazene synthetic opioids heralds a new phase of the opioid crisis. However, limited information exists on the toxic effects of these drugs, aside from a propensity for respiratory depression. With restricted research av...
Dual calcium-voltage optical mapping of regional voltage and calcium signals in intact murine RyR2-R2474S hearts [0.03%]
双钙电压光学映射在完整的小鼠心肌细胞中的区域电压和钙信号映射
Yangpeng Li,Zhu Liu,Christopher O&#x;Shea et al.
Yangpeng Li et al.
Abnormal regional variations in electrical and calcium homeostasis properties have been implicated in catecholaminergic polymorphic ventricular tachycardias (CPVT) attributable to abnormal RyR2-mediated store Ca2+ release, but their underly...
Conditional ablation of MCU exacerbated cardiac pathology in a genetic arrhythmic model of CPVT [0.03%]
MCU条件性敲除可加重遗传性CPVT心律失常模型中心脏损伤
Arpita Deb,Brian D Tow,Jie Hao et al.
Arpita Deb et al.
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic arrhythmic syndrome caused by mutations in the calcium (Ca2+) release channel ryanodine receptor (RyR2) and its accessory proteins. The...