MicroRNA profiling of the feline left heart identifies chamber-specific expression signatures in health and in advanced hypertrophic cardiomyopathy [0.03%]
微小核糖核酸谱分析猫左心房和左心室在健康状态及晚期肥厚性心肌病时的部位特异性表达特征
Jessica Joshua,Jeff L Caswell,Josep M Monné Rodriguez et al.
Jessica Joshua et al.
Hypertrophic cardiomyopathy (HCM) is a common heart disease in humans and cats, nonetheless, the disease pathogenesis is still poorly understood. MicroRNAs are suspected to be involved in the disease process but the myocardial microRNA expr...
Modeling immune checkpoint inhibitor associated myocarditis in vitro and its therapeutic implications [0.03%]
利用体外模型研究免疫检查点抑制剂相关心肌炎及其治疗意义
Garrett Jensen,Xinjie Wang,Jacob Kuempel et al.
Garrett Jensen et al.
Immune checkpoint inhibitor-associated myocarditis is the most lethal side effect of immune checkpoint blockade. Myocarditis leads to persistently increased mortality and lacks effective treatments. The development of patient-relevant disea...
Nitazene opioids and the heart: Identification of a cardiac ion channel target for illicit nitazene opioids [0.03%]
尼塔津类阿片类物质与心脏的作用：非法尼塔津类阿片类物质的心脏离子通道靶点鉴定
Jules C Hancox,Yibo Wang,Caroline S Copeland et al.
Jules C Hancox et al.
The growing use of nitazene synthetic opioids heralds a new phase of the opioid crisis. However, limited information exists on the toxic effects of these drugs, aside from a propensity for respiratory depression. With restricted research av...
Dual calcium-voltage optical mapping of regional voltage and calcium signals in intact murine RyR2-R2474S hearts [0.03%]
双钙电压光学映射在完整的小鼠心肌细胞中的区域电压和钙信号映射
Yangpeng Li,Zhu Liu,Christopher O&#x;Shea et al.
Yangpeng Li et al.
Abnormal regional variations in electrical and calcium homeostasis properties have been implicated in catecholaminergic polymorphic ventricular tachycardias (CPVT) attributable to abnormal RyR2-mediated store Ca2+ release, but their underly...
Conditional ablation of MCU exacerbated cardiac pathology in a genetic arrhythmic model of CPVT [0.03%]
MCU条件性敲除可加重遗传性CPVT心律失常模型中心脏损伤
Arpita Deb,Brian D Tow,Jie Hao et al.
Arpita Deb et al.
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic arrhythmic syndrome caused by mutations in the calcium (Ca2+) release channel ryanodine receptor (RyR2) and its accessory proteins. The...
Cardiac overexpression of a mitochondrial SUR2A splice variant impairs cardiac function and worsens myocardial ischemia reperfusion injury in female mice [0.03%]
心肌细胞中线粒体SUR2A剪接变体过表达会损害心脏功能并加重雌性小鼠的心肌缺血再灌注损伤
Allison C Wexler,Holly Dooge,Sarah El-Meanawy et al.
Allison C Wexler et al.
The small splice variant of the sulfonylurea receptor protein isoform 2 A (SUR2A-55) targets mitochondria and enhances mitoKATP activity. In male mice the overexpression of this protein promotes cardioprotection, reducing myocardial injury ...
Allele-specific dysregulation of lipid and energy metabolism in early-stage hypertrophic cardiomyopathy [0.03%]
肥厚性心肌病早期阶段脂质和能量代谢的等位基因特异性失调
Arpana Vaniya,Anja Karlstaedt,Damla Gulkok et al.
Arpana Vaniya et al.
Introduction: Hypertrophic cardiomyopathy (HCM) results from pathogenic variants in sarcomeric protein genes that increase myocyte energy demand and lead to cardiac hypertrophy. However, it is unknown whether a common met...
Sex differences in cardiac mitochondrial respiration and reactive oxygen species production may predispose Scn1a -/+ mice to cardiac arrhythmias and Sudden Unexpected Death in Epilepsy [0.03%]
Scn1a基因突变小鼠心脏线粒体呼吸和活性氧生成的性别差异可能会导致癫痫突然意外死亡及心律失常
Jessa L Aldridge,Emily Davis Alexander,Allison A Franklin et al.
Jessa L Aldridge et al.
Dravet Syndrome (DS) is a pediatric-onset epilepsy with an elevated risk of Sudden Unexpected Death in Epilepsy (SUDEP). Most individuals with DS possess mutations in the voltage-gated sodium channel gene Scn1a, expressed in both the brain ...
Distinct phenotypes induced by acute hypoxia and TGF-β1 in human adult cardiac fibroblasts [0.03%]
急性缺氧和TGF-β1诱导的人成年心脏纤维母细胞表型差异性研究
Natalie N Khalil,Megan L Rexius-Hall,Sean Escopete et al.
Natalie N Khalil et al.
Myocardial infarction (MI) causes hypoxic injury to downstream myocardial tissue, which initiates a wound healing response that replaces injured myocardial tissue with a scar. Wound healing is a complex process that consists of multiple pha...
Comparative analysis of two independent Myh6-Cre transgenic mouse lines [0.03%]
两独立Myh6-Cre转基因小鼠系的比较分析
Amanda Davenport,Chase W Kessinger,Ryan D Pfeiffer et al.
Amanda Davenport et al.
We have previously shown that the Myh6 promoter drives Cre expression in a subset of male germ line cells in three independent Myh6-Cre mouse lines, including two transgenic lines and one knock-in allele. In this study, we further compared ...