Pooled microarray expression analysis of failing left ventricles reveals extensive cellular-level dysregulation independent of age and sex [0.03%]
pooling分析失败的左心室微阵列表达发现广泛的细胞水平调节独立于年龄和性别
Youdinghuan Chen
Youdinghuan Chen
Existing cardiovascular studies tend to suffer from small sample sizes and unaddressed confounders. Re-profiling of 9 microarray datasets revealed significant global gene expression differences between 358 failing and 191 non-failing left v...
Quest for the ideal assessment of electrical ventricular dyssynchrony in cardiac resynchronization therapy [0.03%]
心室不同步电学评价在心脏再同步治疗中的求索之旅
Uyên Châu Nguyên,Kevin Vernooy,Frits W Prinzen
Uyên Châu Nguyên
This paper reviews the literature on assessing electrical dyssynchrony for patient selection in cardiac resynchronization therapy (CRT). The guideline-recommended electrocardiographic (ECG) criteria for CRT are QRS duration and morphology, ...
Sex, drugs and high fat diet: Characterizing HFpEF in female C57BL6/J mice [0.03%]
性、药物与高脂饮食：关于C57BL6/J雌鼠HFpEF的特征描述
Joshua Travers,Emma L Robinson
Joshua Travers
Selecting repetitive focal and rotational activation patterns with the highest probability of being a source of atrial fibrillation [0.03%]
选择反复出现的具有最高概率成为房颤发病焦点和旋涡激活模式
Ben J M Hermans,Ozan Özgül,Michael Wolf et al.
Ben J M Hermans et al.
Introduction: Repetitive focal and rotational activation patterns are currently used as additional ablation targets for atrial fibrillation (AF). However, there is no evidence that all these detected targets are actual so...
A novel sequential endocardial mapping strategy for locating atrial fibrillation sources based on repetitive conduction patterns: An in-silico study [0.03%]
一种新的序贯心内膜mapping策略，用于基于重复传导模式的定位房颤来源：一项in-silico研究
Victor Gonçalves Marques,Ali Gharaviri,Ozan Özgül et al.
Victor Gonçalves Marques et al.
Background: In persistent atrial fibrillation (AF), localized extra-pulmonary vein sources may contribute to arrhythmia recurrences after pulmonary vein isolation. This in-silico study proposes a high-density sequential m...
Sacubitril/valsartan reduces proteasome activation and cardiomyocyte area in an experimental mouse model of hypertrophy [0.03%]
萨库布维林缬沙坦通过减少激活的蛋白酶体和心肌细胞面积来抑制小鼠实验性肥大模型中的心室重构
Moritz Meyer-Jens,Kristin Wenzel,Karina Grube et al.
Moritz Meyer-Jens et al.
Sacubitril/valsartan (Sac/Val) belongs to the group of angiotensin receptor-neprilysin inhibitors and has been used for the treatment of heart failure (HF) for several years. The mechanisms that mediate the beneficial effects of Sac/Val are...
Rebekah L Gundry,Davor Pavlovic
Rebekah L Gundry
An optimized plasmalogen modulating dietary supplement provides greater protection in a male than female mouse model of dilated cardiomyopathy [0.03%]
一项优化的血浆型磷脂调节型膳食补充剂可为雄性小鼠扩张型心肌病模型提供更多的保护作用，而对雌性小鼠则不然
Teleah G Belkin,Emma I Masterman,Gunes S Yildiz et al.
Teleah G Belkin et al.
We previously reported that plasmalogens, a class of phospholipids, were decreased in a setting of dilated cardiomyopathy (DCM). Plasmalogen levels can be modulated via a dietary supplement called alkylglycerols (AG) which has demonstrated ...
Circulating autophagy regulator Rubicon is linked to increased myocardial infarction risk [0.03%]
循环自噬调节因子Rubicon与增加的心肌梗死风险相关
Marie-Hélène Grazide,Jean-Bernard Ruidavets,Wim Martinet et al.
Marie-Hélène Grazide et al.
Background: The identification of new biomarkers that improve existing cardiovascular risk prediction models for acute coronary syndrome is essential for accurately identifying high-risk patients and refining treatment st...
Genetic deletion of 12/15 lipoxygenase delays vascular remodeling and limits cardiorenal dysfunction after pressure overload [0.03%]
压力超负荷后遗传删除12 / 15-脂氧合酶延迟血管重塑并限制心肾功能障碍
Dae Hyun Lee,Vasundhara Kain,Da-Zhi Wang et al.
Dae Hyun Lee et al.
The lipid metabolizing enzyme 12/15 lipoxygenase (12/15LOX) induces proinflammatory responses that may increase cardiovascular and renal complications after cardiac insult. To define the role of 12/15LOX, 8-12-week-old male C57BL/6J wild-ty...